52 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EIF3F	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (285 aa)
	A0A310TTQ1	Histone H3; Belongs to the histone H3 family. (136 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	A0A1L8I158	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	syk	Tyrosine-protein kinase. (605 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	A0A1L8HCX9	Angiotensin-converting enzyme. (876 aa)
	Ace2.S	Angiotensin-converting enzyme. (730 aa)
	ikbkb	Uncharacterized protein. (769 aa)
	ido1	Uncharacterized protein. (398 aa)
	A0A1L8H1M9	Interleukin-1. (282 aa)
	Il1b.L	Interleukin-1. (145 aa)
	ptpn14-2	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1177 aa)
	ptpn14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1176 aa)
	H2B-2	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (233 aa)
	hist2h3c	Histone H3; Belongs to the histone H3 family. (136 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	A0A1L8FYE8	Tyrosine-protein phosphatase non-receptor type. (462 aa)
	A0A1L8FW52	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	cycs	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ptpn21	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1181 aa)
	adar	Uncharacterized protein. (1291 aa)
	Hist2h2ab.S	Histone H2A; Belongs to the histone H2A family. (139 aa)
	Ptpn21.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1151 aa)
	A0A1L8EY07	Histone H3; Belongs to the histone H3 family. (120 aa)
	Ctla4.L	IG domain-containing protein. (209 aa)
	cyct	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	Ctla4.S	IGv domain-containing protein. (242 aa)
	Cyct.L	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (136 aa)
	h3f3b	Histone H3; Belongs to the histone H3 family. (136 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	ptpn1	Tyrosine-protein phosphatase non-receptor type. (430 aa)
	A0A1L8EKH9	STAT_int domain-containing protein. (635 aa)
	A0A1L8EKE2	Signal transducer and activator of transcription. (760 aa)
	H2B	Histone H2B; Belongs to the histone H2B family. (126 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	klf9	Basic transcription element binding protein 1. (292 aa)
	cxcr1	CXCR2 like protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	nono	P54nrb protein. (464 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ptpn1-2	Tyrosine-protein phosphatase non-receptor type. (428 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (468 aa)
	ptpn6-2	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (587 aa)
	il1b-A	Interleukin-1; Belongs to the IL-1 family. (283 aa)
	gjb1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (265 aa)
	senp7	Sentrin/SUMO-specific protease 7. (901 aa)
	eif2ak2	Double stranded RNA activated protein kinase 1. (578 aa)
	rnf26	LOC100037018 protein. (440 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKE2	A0A1L8FYE8	A0A1L8EKE2	A0A1L8FYE8	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type.	0.508
A0A1L8EKE2	Bcl2.S	A0A1L8EKE2	A0A1L8FSA4	Signal transducer and activator of transcription.	BH4_2 domain-containing protein.	0.506
A0A1L8EKE2	Ptpn11.S	A0A1L8EKE2	Q92124	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	eif2ak2	A0A1L8EKE2	A9ULW3	Signal transducer and activator of transcription.	Double stranded RNA activated protein kinase 1.	0.433
A0A1L8EKE2	ikbkb	A0A1L8EKE2	A0A1L8H261	Signal transducer and activator of transcription.	Uncharacterized protein.	0.501
A0A1L8EKE2	ptpn1	A0A1L8EKE2	A0A1L8ELE6	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type.	0.508
A0A1L8EKE2	ptpn1-2	A0A1L8EKE2	Q6GMA0	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type.	0.508
A0A1L8EKE2	ptpn11b	A0A1L8EKE2	Q6GP31	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	ptpn2	A0A1L8EKE2	Q6DD82	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type.	0.508
A0A1L8EKE2	sumo2	A0A1L8EKE2	A0A1L8EMU2	Signal transducer and activator of transcription.	Small ubiquitin-related modifier.	0.489
A0A1L8EKH9	A0A1L8FYE8	A0A1L8EKH9	A0A1L8FYE8	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type.	0.658
A0A1L8EKH9	A0A1L8I158	A0A1L8EKH9	A0A1L8I158	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.567
A0A1L8EKH9	Bcl2.S	A0A1L8EKH9	A0A1L8FSA4	STAT_int domain-containing protein.	BH4_2 domain-containing protein.	0.588
A0A1L8EKH9	Il1b.L	A0A1L8EKH9	A0A1L8H1M6	STAT_int domain-containing protein.	Interleukin-1.	0.430
A0A1L8EKH9	Ptpn11.S	A0A1L8EKH9	Q92124	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.610
A0A1L8EKH9	eif2ak2	A0A1L8EKH9	A9ULW3	STAT_int domain-containing protein.	Double stranded RNA activated protein kinase 1.	0.470
A0A1L8EKH9	ikbkb	A0A1L8EKH9	A0A1L8H261	STAT_int domain-containing protein.	Uncharacterized protein.	0.505
A0A1L8EKH9	il1b-A	A0A1L8EKH9	B7ZSG9	STAT_int domain-containing protein.	Interleukin-1; Belongs to the IL-1 family.	0.430
A0A1L8EKH9	ptpn1	A0A1L8EKH9	A0A1L8ELE6	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type.	0.579
A0A1L8EKH9	ptpn1-2	A0A1L8EKH9	Q6GMA0	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type.	0.579