42 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	atrip	Uncharacterized protein. (801 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa)
	Mcl1.L	Uncharacterized protein. (277 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	Casp9.S	Uncharacterized protein; Belongs to the peptidase C14A family. (399 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	prkd1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (861 aa)
	eif2a	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (582 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	eif2a-2	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (580 aa)
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Mcm2.L	DNA helicase; Belongs to the MCM family. (886 aa)
	Rad26	Uncharacterized protein. (798 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (885 aa)
	rps6ka3	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (737 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	pdk1	Protein-serine/threonine kinase. (412 aa)
	rps6ka1	Ribosomal protein S6 kinase. (733 aa)
	eif4e	MGC85107 protein; Belongs to the eukaryotic initiation factor 4E family. (213 aa)
	PRDX2	Peroxiredoxin 2. (202 aa)
	Clspn.S	Claspin. (1286 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Mapk1.L	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
	Eif4e1b.S	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (280 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	A0A1L8H9R2	Uncharacterized protein. (1288 aa)
	Mrc1.L	C-type lectin domain-containing protein. (220 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	map2k1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	Ccne1.S	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (408 aa)
	Cdk20.S	Protein kinase domain-containing protein. (376 aa)
	mcl1	Uncharacterized protein. (277 aa)
	Endog.L	Endonuclease. (290 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	prkd1-2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (861 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8H9R2	Atr.L	A0A1L8H9R2	A0A1L8GAP7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.813
A0A1L8H9R2	Chek2.L	A0A1L8H9R2	A0A1L8I0A0	Uncharacterized protein.	Uncharacterized protein.	0.779
A0A1L8H9R2	Clspn.S	A0A1L8H9R2	F8WKR8	Uncharacterized protein.	Claspin.	0.997
A0A1L8H9R2	Mcm2.L	A0A1L8H9R2	A0A1L8GPN4	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.968
A0A1L8H9R2	Mrc1.L	A0A1L8H9R2	A0A1L8H4B7	Uncharacterized protein.	C-type lectin domain-containing protein.	0.933
A0A1L8H9R2	PRDX2	A0A1L8H9R2	G3GBS3	Uncharacterized protein.	Peroxiredoxin 2.	0.472
A0A1L8H9R2	Rad17.L	A0A1L8H9R2	A0A1L8I1Y0	Uncharacterized protein.	Uncharacterized protein.	0.759
A0A1L8H9R2	Rad26	A0A1L8H9R2	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	atrip	A0A1L8H9R2	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.632
A0A1L8H9R2	chek1	A0A1L8H9R2	A0A1L8FFS1	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.933
A0A1L8H9R2	chek1-2	A0A1L8H9R2	A0A1L8FL95	Uncharacterized protein.	Protein kinase domain-containing protein.	0.925
A0A1L8H9R2	mcm2	A0A1L8H9R2	A0A1L8GHP1	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.968
A0A1L8H9R2	mdc1	A0A1L8H9R2	A0A1L8F8K7	Uncharacterized protein.	Uncharacterized protein.	0.497
A0A1L8H9R2	rad51	A0A1L8H9R2	A0A1L8FB28	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.696
A0A1L8H9R2	rad9a	A0A1L8H9R2	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.806
A0A1L8H9R2	topbp1	A0A1L8H9R2	A0A1L8FWJ6	Uncharacterized protein.	Uncharacterized protein.	0.929
Atr.L	A0A1L8H9R2	A0A1L8GAP7	A0A1L8H9R2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.813
Atr.L	Chek2.L	A0A1L8GAP7	A0A1L8I0A0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	Clspn.S	A0A1L8GAP7	F8WKR8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Claspin.	0.955
Atr.L	Mcm2.L	A0A1L8GAP7	A0A1L8GPN4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.838