103 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pbx1	Homeobox domain-containing protein. (454 aa)
	Slc1a7.S	Amino acid transporter. (520 aa)
	wls	Uncharacterized protein. (541 aa)
	Cdh3.S	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
	Slc1a2.S	Amino acid transporter. (503 aa)
	Rock2.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1373 aa)
	ryk	Uncharacterized protein. (596 aa)
	marcks-2	Uncharacterized protein. (286 aa)
	rspo3	Uncharacterized protein. (253 aa)
	A0A1L8G7B1	Amino acid transporter. (537 aa)
	Ptk7.L	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1043 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	gata4	Uncharacterized protein. (392 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1399 aa)
	marcks	Uncharacterized protein. (287 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	A0A1L8FNJ4	Amino acid transporter. (557 aa)
	Rock1.L	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1360 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	Fzd8.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Myc.S	Myc_N domain-containing protein. (176 aa)
	Fzd6.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	cdh2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (947 aa)
	gata6	Uncharacterized protein. (502 aa)
	Rock1.S	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1367 aa)
	egfr	Receptor protein-tyrosine kinase. (1208 aa)
	Eomes.S	T-box_assoc domain-containing protein. (668 aa)
	Nfatc2.S	RHD domain-containing protein. (884 aa)
	notum	Uncharacterized protein. (488 aa)
	Axin1.S	Uncharacterized protein. (839 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	nfatc2	RHD domain-containing protein. (896 aa)
	Notum.L	Uncharacterized protein. (386 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	fzd7	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
	axin1	Uncharacterized protein. (841 aa)
	daam1	Uncharacterized protein. (1077 aa)
	btk	Tyrosine-protein kinase. (648 aa)
	wnt11b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	kras	Uncharacterized protein. (186 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	prom1	Uncharacterized protein. (796 aa)
	wnt4-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
	fzd6	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (724 aa)
	c-Jun	C-Jun protein; Belongs to the bZIP family. (312 aa)
	kras-3	LOC397771 protein. (186 aa)
	hras	Small G-protein H-Ras. (189 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (420 aa)
	gata4-2	MGC81427 protein. (394 aa)
	Xporc-d	Xporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	kras-2	Uncharacterized protein. (187 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	krasl	Uncharacterized protein. (187 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	wnt7b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	xfz8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	Xwnt-8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
	nf-at	Nuclear factor of activated T-cell. (884 aa)
	wif1-2	Wnt inhibitory factor-1. (374 aa)
	wnt6-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	slc1a5	Amino acid transporter. (527 aa)
	slc1a3	Amino acid transporter. (592 aa)
	znrf3	RING-type domain-containing protein. (854 aa)
	A0A1L8HYG4	Amino acid transporter. (681 aa)
	A0A1L8HWZ5	Amino acid transporter. (471 aa)
	A0A1L8HWT0	Amino acid transporter. (562 aa)
	Tcf3.L	BHLH domain-containing protein. (709 aa)
	cxcl10-2	SCY domain-containing protein. (99 aa)
	Proml-1	Uncharacterized protein. (890 aa)
	Tcf4.S	BHLH domain-containing protein. (490 aa)
	A0A1L8HRR7	Amino acid transporter. (542 aa)
	Znrf3.S	RING-type domain-containing protein. (848 aa)
	A0A1L8HNG2	Amino acid transporter. (564 aa)
	cxcl10	SCY domain-containing protein. (99 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Mmp7.L	ZnMc domain-containing protein. (259 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	ccl4	C-C motif chemokine. (89 aa)
	il10-2	Uncharacterized protein. (170 aa)
	Mmp13.S	ZnMc domain-containing protein. (258 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	il10	Uncharacterized protein. (172 aa)
	rnf43	RING-type domain-containing protein. (664 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	wnt16-2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wif1	Uncharacterized protein. (374 aa)
	Ascl1.L	BHLH domain-containing protein. (242 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	Wnt5b.S	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	slc1a7	Amino acid transporter. (564 aa)
	Jun.L	BZIP domain-containing protein; Belongs to the bZIP family. (314 aa)
	Wls.L	Uncharacterized protein. (541 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	nfatc3	RHD domain-containing protein. (885 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	slc1a2	Amino acid transporter. (568 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ascl1.L	Lgr5.L	A0A1L8GY38	A0A1L8GYN0	BHLH domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.403
Ascl1.L	Myc.S	A0A1L8GY38	A0A1L8FTW7	BHLH domain-containing protein.	Myc_N domain-containing protein.	0.497
Ascl1.L	Tcf3.L	A0A1L8GY38	A0A1L8HWC2	BHLH domain-containing protein.	BHLH domain-containing protein.	0.846
Ascl1.L	Tcf4.S	A0A1L8GY38	A0A1L8HRZ9	BHLH domain-containing protein.	BHLH domain-containing protein.	0.730
Ascl1.L	ctnnb1	A0A1L8GY38	Q63ZT4	BHLH domain-containing protein.	Beta-catenin protein.	0.502
Ascl1.L	lgr5	A0A1L8GY38	A0A1L8GUF4	BHLH domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.403
Ascl1.L	myc	A0A1L8GY38	Q6NRN4	BHLH domain-containing protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.546
Ascl1.L	stat3.1	A0A1L8GY38	A0A1L8ERT1	BHLH domain-containing protein.	Signal transducer and activator of transcription.	0.464
Axin1.S	Cdh3.S	A0A1L8ER48	A0A1L8GET9	Uncharacterized protein.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.796
Axin1.S	Fzd6.S	A0A1L8ER48	A0A1L8FTP5	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.514
Axin1.S	Fzd8.L	A0A1L8ER48	A0A1L8FVD0	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.670
Axin1.S	Jun.L	A0A1L8ER48	A0A1L8GLZ4	Uncharacterized protein.	BZIP domain-containing protein; Belongs to the bZIP family.	0.710
Axin1.S	Lgr5.L	A0A1L8ER48	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.583
Axin1.S	Lrp5.L	A0A1L8ER48	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.998
Axin1.S	Mmp7.L	A0A1L8ER48	A0A1L8HJ87	Uncharacterized protein.	ZnMc domain-containing protein.	0.424
Axin1.S	Myc.S	A0A1L8ER48	A0A1L8FTW7	Uncharacterized protein.	Myc_N domain-containing protein.	0.799
Axin1.S	Nfatc2.S	A0A1L8ER48	A0A1L8ELF6	Uncharacterized protein.	RHD domain-containing protein.	0.479
Axin1.S	Notum.L	A0A1L8ER48	A0A1L8ETE8	Uncharacterized protein.	Uncharacterized protein.	0.483
Axin1.S	Rock1.L	A0A1L8ER48	A0A1L8FYP1	Uncharacterized protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.407
Axin1.S	Rock1.S	A0A1L8ER48	A0A1L8FSV4	Uncharacterized protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.407