15 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	smarcal1	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (960 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	atrip	Uncharacterized protein. (801 aa)
	Rad26	Uncharacterized protein. (798 aa)
	Tipin.S	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (361 aa)
	mgst1	Uncharacterized protein. (155 aa)
	tipin	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (362 aa)
	Tp53.L	P53 domain-containing protein. (137 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	primpol	Uncharacterized protein. (675 aa)
	Xpa.L	XPA_C domain-containing protein. (265 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chek2.L	Hus1	A0A1L8I0A0	Q8JHD8	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.948
Chek2.L	Rad26	A0A1L8I0A0	A0A1L8GP12	Uncharacterized protein.	Uncharacterized protein.	0.895
Chek2.L	Rpa1.L	A0A1L8I0A0	A0A1L8HDB4	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.744
Chek2.L	Tipin.S	A0A1L8I0A0	A0A1L8GSF3	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.828
Chek2.L	Tp53.L	A0A1L8I0A0	A0A1L8H4M6	Uncharacterized protein.	P53 domain-containing protein.	0.999
Chek2.L	Xpa.L	A0A1L8I0A0	A0A1L8HX71	Uncharacterized protein.	XPA_C domain-containing protein.	0.579
Chek2.L	atrip	A0A1L8I0A0	A0A1L8GH95	Uncharacterized protein.	Uncharacterized protein.	0.895
Chek2.L	pcna	A0A1L8I0A0	Q9I893	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.491
Chek2.L	rad9a	A0A1L8I0A0	Q7ZZU5	Uncharacterized protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.953
Chek2.L	smarcal1	A0A1L8I0A0	A0A1L8EVE4	Uncharacterized protein.	Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.	0.609
Chek2.L	tipin	A0A1L8I0A0	A0A1L8H168	Uncharacterized protein.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.828
Chek2.L	topbp1	A0A1L8I0A0	A0A1L8FWJ6	Uncharacterized protein.	Uncharacterized protein.	0.932
Hus1	Chek2.L	Q8JHD8	A0A1L8I0A0	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.948
Hus1	Rad26	Q8JHD8	A0A1L8GP12	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.982
Hus1	Rpa1.L	Q8JHD8	A0A1L8HDB4	Checkpoint protein; Belongs to the HUS1 family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.965
Hus1	Tipin.S	Q8JHD8	A0A1L8GSF3	Checkpoint protein; Belongs to the HUS1 family.	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	0.919
Hus1	Tp53.L	Q8JHD8	A0A1L8H4M6	Checkpoint protein; Belongs to the HUS1 family.	P53 domain-containing protein.	0.786
Hus1	Xpa.L	Q8JHD8	A0A1L8HX71	Checkpoint protein; Belongs to the HUS1 family.	XPA_C domain-containing protein.	0.652
Hus1	atrip	Q8JHD8	A0A1L8GH95	Checkpoint protein; Belongs to the HUS1 family.	Uncharacterized protein.	0.981
Hus1	rad9a	Q8JHD8	Q7ZZU5	Checkpoint protein; Belongs to the HUS1 family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.999