STRINGSTRING
rspo3 rspo3 Hdac5.S Hdac5.S fzd2 fzd2 hdac4 hdac4 Frzb.S Frzb.S fzd5 fzd5 hdac5 hdac5 Frzb-1 Frzb-1 Hdac4.L Hdac4.L fzd7 fzd7 A0A1L8EZU6 A0A1L8EZU6 daam1 daam1 Hif-1a Hif-1a Notch1.S Notch1.S prickle3-b prickle3-b NumbL NumbL vangl2 vangl2 notch1 notch1 wnt11b wnt11b A0A1L8F8U7 A0A1L8F8U7 A0A1L8FAA5 A0A1L8FAA5 numbl numbl fmn1 fmn1 vangl2-2 vangl2-2 tnks2 tnks2 Drd2.S Drd2.S wnt4 wnt4 Tcf7l2.L Tcf7l2.L dkk1 dkk1 Drd2.L Drd2.L wnt4-2 wnt4-2 A0A1L8FQM4 A0A1L8FQM4 Shh.L Shh.L Fzd8.L Fzd8.L fzd1 fzd1 dgat1 dgat1 A0A1L8G0W2 A0A1L8G0W2 A0A1L8G2V6 A0A1L8G2V6 ankrd6 ankrd6 A0A1L8G6Q8 A0A1L8G6Q8 A0A1L8G8Y0 A0A1L8G8Y0 ankrd6-2 ankrd6-2 Cdh3.S Cdh3.S prickle2 prickle2 Myod1.L Myod1.L Lrp5.L Lrp5.L cdh1 cdh1 cdh3 cdh3 soat1 soat1 prickle2-2 prickle2-2 A0A1L8GQT6 A0A1L8GQT6 sfrp1 sfrp1 tcf7l1 tcf7l1 hgf hgf prickle1 prickle1 lgr5 lgr5 Hdac3.S Hdac3.S neurog1 neurog1 wif1 wif1 Lgr5.L Lgr5.L Prickle1.L Prickle1.L hgf-2 hgf-2 Sfrp1.L Sfrp1.L Tp53.L Tp53.L A0A1L8H5Q6 A0A1L8H5Q6 wnt1 wnt1 hdac7 hdac7 Soat2.S Soat2.S Fzd4.S Fzd4.S vangl1-2 vangl1-2 hdac1 hdac1 Wnt1.L Wnt1.L hdac7-2 hdac7-2 wnt11 wnt11 lef1 lef1 dkk2 dkk2 tnks tnks lox lox sfrp2 sfrp2 ptch1 ptch1 Lox.L Lox.L tyro3 tyro3 wif1-2 wif1-2 tcf7l1-2 tcf7l1-2 xfz8 xfz8 invs-a invs-a dkk1-2 dkk1-2 cdh11-2 cdh11-2 myod1-a myod1-a ctnnb1 ctnnb1 soat1-2 soat1-2 Xporc-d Xporc-d hif1a hif1a slc25a20-2 slc25a20-2 sfrp2-2 sfrp2-2 hdac1-2 hdac1-2 ccnd1 ccnd1 lef1-2 lef1-2 ptch1-2 ptch1-2 dkk2-2 dkk2-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rspo3Uncharacterized protein. (253 aa)
Hdac5.SHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1048 aa)
fzd2Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
Frzb.SUncharacterized protein. (319 aa)
fzd5Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1016 aa)
Frzb-1Uncharacterized protein. (319 aa)
Hdac4.LHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1171 aa)
fzd7Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (549 aa)
A0A1L8EZU6PID domain-containing protein. (642 aa)
daam1Uncharacterized protein. (1077 aa)
Hif-1aUncharacterized protein. (800 aa)
Notch1.SUncharacterized protein. (2524 aa)
prickle3-bPrickle planar cell polarity protein 3-B; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules. Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells. D [...] (536 aa)
NumbLPID domain-containing protein. (588 aa)
vangl2Vang-like protein. (521 aa)
notch1Uncharacterized protein. (2521 aa)
wnt11bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
A0A1L8F8U7PID domain-containing protein. (588 aa)
A0A1L8FAA5Uncharacterized protein. (1077 aa)
numblPID domain-containing protein. (651 aa)
fmn1FH2 domain-containing protein. (1393 aa)
vangl2-2Vang-like protein. (521 aa)
tnks2Poly [ADP-ribose] polymerase. (1165 aa)
Drd2.SG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Tcf7l2.LHMG box domain-containing protein. (482 aa)
dkk1Dickkopf_N domain-containing protein. (263 aa)
Drd2.LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (438 aa)
wnt4-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
A0A1L8FQM4Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
Shh.LHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
Fzd8.LUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
fzd1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
dgat1O-acyltransferase. (472 aa)
A0A1L8G0W2Uncharacterized protein. (1082 aa)
A0A1L8G2V6Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (467 aa)
ankrd6ANK_REP_REGION domain-containing protein. (776 aa)
A0A1L8G6Q8Uncharacterized protein. (1078 aa)
A0A1L8G8Y0Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
ankrd6-2ANK_REP_REGION domain-containing protein. (776 aa)
Cdh3.SUncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (880 aa)
prickle2Uncharacterized protein. (833 aa)
Myod1.LMyogenic factor. (289 aa)
Lrp5.LUncharacterized protein. (1517 aa)
cdh1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
cdh3Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
soat1O-acyltransferase. (553 aa)
prickle2-2Uncharacterized protein. (833 aa)
A0A1L8GQT6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
sfrp1Uncharacterized protein. (311 aa)
tcf7l1HMG box domain-containing protein. (551 aa)
hgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
prickle1Uncharacterized protein. (835 aa)
lgr5G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
Hdac3.SHistone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
neurog1BHLH domain-containing protein. (229 aa)
wif1Uncharacterized protein. (374 aa)
Lgr5.LG_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
Prickle1.LUncharacterized protein. (832 aa)
hgf-2Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
Sfrp1.LUncharacterized protein. (311 aa)
Tp53.LP53 domain-containing protein. (137 aa)
A0A1L8H5Q6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
hdac7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (972 aa)
Soat2.SO-acyltransferase. (532 aa)
Fzd4.SUncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
vangl1-2Vang-like protein. (499 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
Wnt1.LProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
hdac7-2Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (957 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
lef1HMG box domain-containing protein. (372 aa)
dkk2Dickkopf_N domain-containing protein. (255 aa)
tnksPoly [ADP-ribose] polymerase. (1298 aa)
loxUncharacterized protein. (422 aa)
sfrp2Uncharacterized protein. (295 aa)
ptch1SSD domain-containing protein. (1422 aa)
Lox.LUncharacterized protein. (457 aa)
tyro3Tyrosine kinase. (880 aa)
wif1-2Wnt inhibitory factor-1. (374 aa)
tcf7l1-2Transcription factor XTCF-3b. (554 aa)
xfz8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
invs-aInversin. (1007 aa)
dkk1-2Dickkopf homolog 1. (259 aa)
cdh11-2Cadherin; Cadherins are calcium-dependent cell adhesion proteins. (794 aa)
myod1-aMyoblast determination protein 1 homolog A; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (289 aa)
ctnnb1Beta-catenin protein. (781 aa)
soat1-2O-acyltransferase. (550 aa)
Xporc-dXporc-d protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
hif1aHif1a-prov protein. (802 aa)
slc25a20-2Slc25a20-prov protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
sfrp2-2Sfrp2-prov protein. (298 aa)
hdac1-2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (480 aa)
ccnd1Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
lef1-2Lymphoid enhancer factor XLEF-1. (372 aa)
ptch1-2Patched-1. (1418 aa)
dkk2-2Dickkopf homolog 2. (255 aa)
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
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