(58 nodes) (2023) Kidney and blood pressure regulation-latest evidence for molecular mechanisms. network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8GUI6	Uncharacterized protein. (183 aa)
	kcnj16	Uncharacterized protein. (413 aa)
	wnk4	Protein kinase domain-containing protein. (1573 aa)
	Scnn1b.S	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (646 aa)
	wnk4-2	Protein kinase domain-containing protein. (1575 aa)
	xpnpep2	Uncharacterized protein; Belongs to the peptidase M24B family. (679 aa)
	kcnj10	Uncharacterized protein. (378 aa)
	xpnpep2-2	Uncharacterized protein; Belongs to the peptidase M24B family. (675 aa)
	add3	Aldolase_II domain-containing protein. (689 aa)
	kcnj1	Uncharacterized protein. (371 aa)
	trpv5	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (789 aa)
	Scnn1d.L	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (603 aa)
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	Clcnkb.L	Chloride channel protein. (688 aa)
	A0A1L8FWI9	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (792 aa)
	sgk1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	A0A1L8GE13	CALCITONIN domain-containing protein. (138 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	bsnd	Uncharacterized protein. (298 aa)
	A0A1L8GIE1	CALCITONIN domain-containing protein. (138 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	bsnd-2	Uncharacterized protein. (356 aa)
	Wnk1.S	Uncharacterized protein. (265 aa)
	pax8	Paired domain-containing protein. (467 aa)
	add2	Aldolase_II domain-containing protein. (721 aa)
	Furin.S	P/Homo B domain-containing protein; Belongs to the peptidase S8 family. (783 aa)
	A0A1L8GTY4	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (776 aa)
	A0A1L8GTY8	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa)
	Slc26a4.S	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (778 aa)
	ifng	Uncharacterized protein. (182 aa)
	A0A1L8GZ57	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (777 aa)
	A0A1L8GZ78	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (836 aa)
	slc26a4.3	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (778 aa)
	slc12a1	Uncharacterized protein. (1086 aa)
	add2-2	Aldolase_II domain-containing protein. (717 aa)
	pax8-2	Paired domain-containing protein. (465 aa)
	Ren.S	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)
	nr3c2	Uncharacterized protein. (981 aa)
	enpep	Aminopeptidase. (978 aa)
	Fabp2.S	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	Nedd4l.S	Uncharacterized protein. (979 aa)
	add1-2	Aldolase_II domain-containing protein. (843 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	enpep-2	Aminopeptidase. (973 aa)
	nedd4l	Uncharacterized protein. (971 aa)
	Prss8.S	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (329 aa)
	oxsr1	Stk39 protein. (528 aa)
	fabp2	Fatty acid binding protein 2, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	add3-2	LOC432146 protein. (687 aa)
	furin	LOC398345 protein; Belongs to the peptidase S8 family. (785 aa)
	kcnj10-2	LOC494778 protein. (378 aa)
	nr3c2-2	Nr3c2 protein. (979 aa)
	kcnj1-2	MGC86330 protein. (372 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8FND1	A0A1L8GUI6	A0A1L8FND1	A0A1L8GUI6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.513
A0A1L8FND1	Egf.L	A0A1L8FND1	A0A1L8HUT3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.962
A0A1L8FND1	Furin.S	A0A1L8FND1	A0A1L8GSP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	P/Homo B domain-containing protein; Belongs to the peptidase S8 family.	0.556
A0A1L8FND1	Nedd4l.S	A0A1L8FND1	A0A1L8HRV4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.550
A0A1L8FND1	Prkacb.S	A0A1L8FND1	A0A1L8GLU4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.724
A0A1L8FND1	Ren.S	A0A1L8FND1	A0A1L8H6R4	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.693
A0A1L8FND1	furin	A0A1L8FND1	Q5XHG7	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	LOC398345 protein; Belongs to the peptidase S8 family.	0.557
A0A1L8FND1	ifng	A0A1L8FND1	A0A1L8GYI9	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.515
A0A1L8FND1	ins	A0A1L8FND1	A0A1L8GD41	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.907
A0A1L8FND1	ins-2	A0A1L8FND1	B7ZQP1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.905
A0A1L8FND1	nedd4l	A0A1L8FND1	A0A1L8I2Q5	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.489
A0A1L8FND1	prkaca	A0A1L8FND1	Q90WN3	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.724
A0A1L8FND1	prkacb	A0A1L8FND1	A0A1L8GFG6	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.751
A0A1L8FND1	sgk1	A0A1L8FND1	A0A1L8G2L0	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.781
A0A1L8FWI9	Ren.S	A0A1L8FWI9	A0A1L8H6R4	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.426
A0A1L8FWI9	Wnk1.S	A0A1L8FWI9	A0A1L8GQQ4	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Uncharacterized protein.	0.443
A0A1L8FWI9	kcnj1	A0A1L8FWI9	A0A1L8FFR6	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Uncharacterized protein.	0.488
A0A1L8FWI9	kcnj1-2	A0A1L8FWI9	Q6AX29	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	MGC86330 protein.	0.512
A0A1L8FWI9	oxsr1	A0A1L8FWI9	A0JPG0	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Stk39 protein.	0.510
A0A1L8FWI9	slc12a1	A0A1L8FWI9	A0A1L8H0K3	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.	Uncharacterized protein.	0.451