39 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lef1-2	Lymphoid enhancer factor XLEF-1. (372 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	Dkk3.S	Dickkopf_N domain-containing protein. (257 aa)
	sox10	HMG box domain-containing protein. (438 aa)
	Lrp5.L	Uncharacterized protein. (1517 aa)
	sox10-2	HMG box domain-containing protein. (446 aa)
	lgr5	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	Lgr5.L	G_PROTEIN_RECEP_F1_2 domain-containing protein. (902 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	Wnt1.L	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	lef1	HMG box domain-containing protein. (372 aa)
	dkk2	Dickkopf_N domain-containing protein. (255 aa)
	Kremen1.S	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (452 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	kremen1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (450 aa)
	slc31a2	Transmembrane protein. (172 aa)
	dkk1-2	Dickkopf homolog 1. (259 aa)
	sdc2-2	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (191 aa)
	gpc4-2	Xgly4 protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
	tbp	LOC503680 protein. (296 aa)
	ctnnb1	Beta-catenin protein. (781 aa)
	axin2-2	MGC81576 protein. (707 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	dkk2-2	Dickkopf homolog 2. (255 aa)
	A0A1L8ENI4	Uncharacterized protein. (815 aa)
	Kremen2.S	Uncharacterized protein. (421 aa)
	A0A1L8EUY4	Uncharacterized protein. (818 aa)
	kremen2	Uncharacterized protein. (420 aa)
	gpc4	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (549 aa)
	Hprt1.L	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (289 aa)
	A0A1L8FG40	Uncharacterized protein. (2091 aa)
	dkk1	Dickkopf_N domain-containing protein. (263 aa)
	A0A1L8FLY9	Uncharacterized protein. (1971 aa)
	axin2	Uncharacterized protein. (707 aa)
	sdc2	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (190 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENI4	Dkk3.S	A0A1L8ENI4	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.527
A0A1L8ENI4	Gapdh.S	A0A1L8ENI4	Q7ZY52	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.628
A0A1L8ENI4	Lgr5.L	A0A1L8ENI4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	Lrp5.L	A0A1L8ENI4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928
A0A1L8ENI4	Wnt1.L	A0A1L8ENI4	A0A1L8HHR8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	ctnnb1	A0A1L8ENI4	Q63ZT4	Uncharacterized protein.	Beta-catenin protein.	0.998
A0A1L8ENI4	dkk1	A0A1L8ENI4	A0A1L8FIS6	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.899
A0A1L8ENI4	dkk1-2	A0A1L8ENI4	O57464	Uncharacterized protein.	Dickkopf homolog 1.	0.900
A0A1L8ENI4	dkk2	A0A1L8ENI4	A0A1L8HM80	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.665
A0A1L8ENI4	dkk2-2	A0A1L8ENI4	Q9DDA4	Uncharacterized protein.	Dickkopf homolog 2.	0.666
A0A1L8ENI4	gapdh	A0A1L8ENI4	Q8AY70	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.594
A0A1L8ENI4	lef1	A0A1L8ENI4	A0A1L8HM07	Uncharacterized protein.	HMG box domain-containing protein.	0.922
A0A1L8ENI4	lef1-2	A0A1L8ENI4	Q90ZB8	Uncharacterized protein.	Lymphoid enhancer factor XLEF-1.	0.922
A0A1L8ENI4	lgr5	A0A1L8ENI4	A0A1L8GUF4	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8ENI4	wnt1	A0A1L8ENI4	A0A1L8H9S8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
A0A1L8ENI4	wnt3a	A0A1L8ENI4	A0A1L8FUX8	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.929
A0A1L8EUY4	Dkk3.S	A0A1L8EUY4	A0A1L8GDZ7	Uncharacterized protein.	Dickkopf_N domain-containing protein.	0.527
A0A1L8EUY4	Gapdh.S	A0A1L8EUY4	Q7ZY52	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.628
A0A1L8EUY4	Lgr5.L	A0A1L8EUY4	A0A1L8GYN0	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.817
A0A1L8EUY4	Lrp5.L	A0A1L8EUY4	A0A1L8GJX4	Uncharacterized protein.	Uncharacterized protein.	0.928