67 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8FND1	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (100 aa)
	Casp3.L	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	Met.S	Uncharacterized protein. (1354 aa)
	hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1115 aa)
	fgfr1	Fibroblast growth factor receptor. (810 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	cdh3	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	cdh1	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (871 aa)
	tpr	TPR_MLP1_2 domain-containing protein. (2321 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	Inpp5d.L	SH2 domain-containing protein. (1111 aa)
	pik3cb-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Thpo.L	Uncharacterized protein. (191 aa)
	plek	Uncharacterized protein. (350 aa)
	tgfb2-2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	pik3cb	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	inpp5d	SH2 domain-containing protein. (1099 aa)
	Thpo.S	Uncharacterized protein. (172 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	snai2	Uncharacterized protein. (266 aa)
	G50	Uncharacterized protein. (980 aa)
	crkl-2	MGC81407 protein. (302 aa)
	snai2-2	Zinc finger transcription factor slug beta. (266 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	crkl	MGC84382 protein. (302 aa)
	pak5	Non-specific serine/threonine protein kinase. (650 aa)
	src	Tyrosine-protein kinase. (532 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	ins-2	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
	pten	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	Egf.L	Uncharacterized protein. (1031 aa)
	A0A1L8ELV2	Tyrosine-protein kinase. (461 aa)
	grb2	Uncharacterized protein. (229 aa)
	erbb2	Receptor protein-tyrosine kinase. (1299 aa)
	A0A1L8ET48	Tyrosine-protein kinase. (466 aa)
	grb2-2	Uncharacterized protein. (229 aa)
	A0A1L8EZT5	Tyrosine-protein kinase receptor. (1323 aa)
	abl1	Tyrosine-protein kinase. (1122 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	A0A1L8F415	Non-specific serine/threonine protein kinase. (660 aa)
	shc1	Uncharacterized protein. (605 aa)
	gab3	PH domain-containing protein. (538 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	A0A1L8FAF1	Tyrosine-protein kinase receptor. (1237 aa)
	Shc1.L	Uncharacterized protein. (601 aa)
	egfr-2	Receptor protein-tyrosine kinase. (1210 aa)
	A0A1L8FW11	Uncharacterized protein. (139 aa)
	cdh2	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (947 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	Epha2.L	Uncharacterized protein. (948 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	casp3.2	Uncharacterized protein; Belongs to the peptidase C14A family. (288 aa)
	foxo1-2	Fork-head domain-containing protein. (631 aa)
	Crk.L	Uncharacterized protein. (297 aa)
	foxo1	Fork-head domain-containing protein. (626 aa)
	crk	Uncharacterized protein. (297 aa)
	epo	Uncharacterized protein. (181 aa)
	fgfr1-2	Fibroblast growth factor receptor. (812 aa)
	Tjp1.S	Uncharacterized protein; Belongs to the MAGUK family. (1705 aa)
	hgf-2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	Met.L	Uncharacterized protein. (1355 aa)
	ifng	Uncharacterized protein. (182 aa)
	A0A1L8GUI6	Uncharacterized protein. (183 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ELV2	Crk.L	A0A1L8ELV2	A0A1L8HDP2	Tyrosine-protein kinase.	Uncharacterized protein.	0.415
A0A1L8ELV2	Met.L	A0A1L8ELV2	A0A1L8GYT6	Tyrosine-protein kinase.	Uncharacterized protein.	0.589
A0A1L8ELV2	Met.S	A0A1L8ELV2	A0A1L8GU34	Tyrosine-protein kinase.	Uncharacterized protein.	0.589
A0A1L8ELV2	Ptpn11.S	A0A1L8ELV2	Q92124	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.459
A0A1L8ELV2	Shc1.L	A0A1L8ELV2	A0A1L8FDE2	Tyrosine-protein kinase.	Uncharacterized protein.	0.423
A0A1L8ELV2	crk	A0A1L8ELV2	A0A1L8H629	Tyrosine-protein kinase.	Uncharacterized protein.	0.415
A0A1L8ELV2	crkl	A0A1L8ELV2	Q66KG8	Tyrosine-protein kinase.	MGC84382 protein.	0.411
A0A1L8ELV2	crkl-2	A0A1L8ELV2	Q6NTZ1	Tyrosine-protein kinase.	MGC81407 protein.	0.411
A0A1L8ELV2	egfr-2	A0A1L8ELV2	A0A1L8FWP8	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.425
A0A1L8ELV2	erbb2	A0A1L8ELV2	A0A1L8ES20	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.425
A0A1L8ELV2	grb2	A0A1L8ELV2	A0A1L8EMZ6	Tyrosine-protein kinase.	Uncharacterized protein.	0.536
A0A1L8ELV2	grb2-2	A0A1L8ELV2	A0A1L8EUF2	Tyrosine-protein kinase.	Uncharacterized protein.	0.536
A0A1L8ELV2	pten	A0A1L8ELV2	A1L2J3	Tyrosine-protein kinase.	Phosphatase and tensin homolog S homeolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.406
A0A1L8ELV2	ptpn11b	A0A1L8ELV2	Q6GP31	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.459
A0A1L8ELV2	shc1	A0A1L8ELV2	A0A1L8F596	Tyrosine-protein kinase.	Uncharacterized protein.	0.423
A0A1L8ELV2	src	A0A1L8ELV2	Q2TAR1	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.499
A0A1L8ET48	Crk.L	A0A1L8ET48	A0A1L8HDP2	Tyrosine-protein kinase.	Uncharacterized protein.	0.415
A0A1L8ET48	Met.L	A0A1L8ET48	A0A1L8GYT6	Tyrosine-protein kinase.	Uncharacterized protein.	0.589
A0A1L8ET48	Met.S	A0A1L8ET48	A0A1L8GU34	Tyrosine-protein kinase.	Uncharacterized protein.	0.589
A0A1L8ET48	Ptpn11.S	A0A1L8ET48	Q92124	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.459