33 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Atr.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2654 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Hus1	Checkpoint protein; Belongs to the HUS1 family. (282 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (377 aa)
	Gapdh.S	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ddx17	LOC398649 protein; Belongs to the DEAD box helicase family. (610 aa)
	PIK3R1	Phosphoinositide-3-kinase. (722 aa)
	Rad17.L	Uncharacterized protein. (674 aa)
	Chek2.L	Uncharacterized protein. (392 aa)
	wrn	Uncharacterized protein. (1434 aa)
	brca2	Tower domain-containing protein. (3177 aa)
	Rpa1.L	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (609 aa)
	rad50-2	Zinc-hook domain-containing protein. (1312 aa)
	rad50	Zinc-hook domain-containing protein. (1311 aa)
	fancd2	Uncharacterized protein. (1445 aa)
	Rad26	Uncharacterized protein. (798 aa)
	atrip	Uncharacterized protein. (801 aa)
	rnf168-2	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (565 aa)
	Brca1.L	Uncharacterized protein. (1582 aa)
	hagh-2	Lactamase_B domain-containing protein. (315 aa)
	Setx.L	Uncharacterized protein. (2537 aa)
	mdc1	Uncharacterized protein. (2103 aa)
	Fancm.L	Uncharacterized protein. (2165 aa)
	aqr	Uncharacterized protein. (1566 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (474 aa)
	chek1-2	Protein kinase domain-containing protein. (510 aa)
	hagh	Lactamase_B domain-containing protein. (310 aa)
	rbbp8	Uncharacterized protein. (846 aa)
	topbp1	Uncharacterized protein. (1573 aa)
	Rbbp8.L	Uncharacterized protein. (856 aa)
	Prkdc.L	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (4146 aa)
	rnf168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (554 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atr.L	Brca1.L	A0A1L8GAP7	A0A1L8ETS4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.998
Atr.L	Chek2.L	A0A1L8GAP7	A0A1L8I0A0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	Fancm.L	A0A1L8GAP7	A0A1L8F9Q1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.998
Atr.L	Hus1	A0A1L8GAP7	Q8JHD8	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Checkpoint protein; Belongs to the HUS1 family.	0.999
Atr.L	Prkdc.L	A0A1L8GAP7	A0A1L8FYZ4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.552
Atr.L	Rad17.L	A0A1L8GAP7	A0A1L8I1Y0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.991
Atr.L	Rad26	A0A1L8GAP7	A0A1L8GP12	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	Rbbp8.L	A0A1L8GAP7	A0A1L8FYP2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.915
Atr.L	Rpa1.L	A0A1L8GAP7	A0A1L8HDB4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.993
Atr.L	Setx.L	A0A1L8GAP7	A0A1L8F6C4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.459
Atr.L	atrip	A0A1L8GAP7	A0A1L8GH95	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.999
Atr.L	brca2	A0A1L8GAP7	A0A1L8HIX3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Tower domain-containing protein.	0.775
Atr.L	chek1	A0A1L8GAP7	A0A1L8FFS1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.999
Atr.L	chek1-2	A0A1L8GAP7	A0A1L8FL95	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Protein kinase domain-containing protein.	0.999
Atr.L	fancd2	A0A1L8GAP7	A0A1L8GP71	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.950
Atr.L	mdc1	A0A1L8GAP7	A0A1L8F8K7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.846
Atr.L	pcna	A0A1L8GAP7	Q9I893	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.743
Atr.L	rad50	A0A1L8GAP7	A0A1L8GVF0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Zinc-hook domain-containing protein.	0.955
Atr.L	rad50-2	A0A1L8GAP7	A0A1L8GXM0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Zinc-hook domain-containing protein.	0.955
Atr.L	rad9a	A0A1L8GAP7	Q7ZZU5	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.998