(72 nodes) Hedgehog signaling pathway network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	spop	Uncharacterized protein. (374 aa)
	smurf2	E3 ubiquitin-protein ligase. (751 aa)
	gli2	Uncharacterized protein. (1468 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	A0A1L8ENZ0	Uncharacterized protein. (400 aa)
	A0A1L8EPZ7	E3 ubiquitin-protein ligase. (729 aa)
	mosmo	Uncharacterized protein. (167 aa)
	spop-2	Uncharacterized protein. (374 aa)
	Csnk1d.S	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	A0A1L8EV30	E3 ubiquitin-protein ligase. (751 aa)
	ihh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	spopl	Uncharacterized protein. (392 aa)
	Lrp2.L	Uncharacterized protein. (4658 aa)
	Smurf1.L	E3 ubiquitin-protein ligase. (731 aa)
	mosmo-2	Uncharacterized protein. (167 aa)
	A0A1L8FEJ7	Suppressor of fused homolog. (474 aa)
	cdon	Uncharacterized protein. (1247 aa)
	megf8	Uncharacterized protein. (2730 aa)
	A0A1L8FHE3	Cyclin_C domain-containing protein. (152 aa)
	Cdon.L	Uncharacterized protein. (1250 aa)
	megf8-2	Uncharacterized protein. (2730 aa)
	A0A1L8FQM4	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (429 aa)
	gli3	Uncharacterized protein. (1565 aa)
	Bcl2.S	BH4_2 domain-containing protein. (253 aa)
	Shh.L	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (444 aa)
	gli3-2	Uncharacterized protein. (1568 aa)
	A0A1L8FXP7	BH4_2 domain-containing protein. (300 aa)
	cul3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	cul3-2	CULLIN_2 domain-containing protein; Belongs to the cullin family. (768 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (396 aa)
	A0A1L8GH49	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
	Prkacb.S	Uncharacterized protein; Belongs to the protein kinase superfamily. (338 aa)
	csnk1g1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (460 aa)
	Smo.S	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (814 aa)
	A0A1L8GVD3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (699 aa)
	Kif3a.L	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (669 aa)
	csnk1a1-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
	Smo.L	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
	A0A1L8H0B6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (460 aa)
	kif7	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1383 aa)
	Arrb2.L	Arrestin_C domain-containing protein. (446 aa)
	boc	Uncharacterized protein. (1068 aa)
	A0A1L8H5Q6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	A0A1L8H6N0	Uncharacterized protein. (243 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (398 aa)
	gli1	Uncharacterized protein. (1361 aa)
	boc-2	Uncharacterized protein. (1070 aa)
	dhh-2	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
	Gli1.L	Uncharacterized protein. (1362 aa)
	hhip	EGF-like domain-containing protein. (698 aa)
	gas1	Uncharacterized protein. (299 aa)
	A0A1L8HQ32	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	evc	Uncharacterized protein. (928 aa)
	Evc2.L	Uncharacterized protein. (1243 aa)
	csnk1g2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (412 aa)
	gas1-2	Uncharacterized protein. (284 aa)
	ptch1	SSD domain-containing protein. (1422 aa)
	A0A1L8HZZ6	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	A0A310U5I6	Arrestin_C domain-containing protein. (388 aa)
	csnk1g3	LOC100036840 protein; Belongs to the protein kinase superfamily. (424 aa)
	ccnd2	Cyclin D2; Belongs to the cyclin family. (291 aa)
	ccnd2-2	MGC132398 protein; Belongs to the cyclin family. (291 aa)
	MGC114992	MGC114992 protein; Belongs to the cullin family. (776 aa)
	MGC85146	MGC85146 protein; Belongs to the protein kinase superfamily. (424 aa)
	ccndx	MGC83328 protein; Belongs to the cyclin family. (290 aa)
	hhip-2	Hedgehog-interacting protein. (696 aa)
	ptch2	SSD domain-containing protein. (1422 aa)
	ccnd1	Ccnd1-prov protein; Belongs to the cyclin family. (291 aa)
	prkaca	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
	ptch1-2	Patched-1. (1418 aa)
	ptch2-2	Patched-2. (1413 aa)
	csnk1e	Casein kinase I epsilon; Belongs to the protein kinase superfamily. (416 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8ENZ0	A0A1L8FEJ7	A0A1L8ENZ0	A0A1L8FEJ7	Uncharacterized protein.	Suppressor of fused homolog.	0.933
A0A1L8ENZ0	Gli1.L	A0A1L8ENZ0	A0A1L8HI29	Uncharacterized protein.	Uncharacterized protein.	0.913
A0A1L8ENZ0	MGC114992	A0A1L8ENZ0	Q4V7X4	Uncharacterized protein.	MGC114992 protein; Belongs to the cullin family.	0.814
A0A1L8ENZ0	cul3	A0A1L8ENZ0	A0A1L8G4G3	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.991
A0A1L8ENZ0	cul3-2	A0A1L8ENZ0	A0A1L8GAJ9	Uncharacterized protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.991
A0A1L8ENZ0	gli1	A0A1L8ENZ0	A0A1L8HA22	Uncharacterized protein.	Uncharacterized protein.	0.913
A0A1L8ENZ0	gli2	A0A1L8ENZ0	A0A1L8ENK6	Uncharacterized protein.	Uncharacterized protein.	0.904
A0A1L8ENZ0	gli3	A0A1L8ENZ0	A0A1L8FRV1	Uncharacterized protein.	Uncharacterized protein.	0.904
A0A1L8ENZ0	gli3-2	A0A1L8ENZ0	A0A1L8FWR2	Uncharacterized protein.	Uncharacterized protein.	0.904
A0A1L8EPZ7	A0A1L8EV30	A0A1L8EPZ7	A0A1L8EV30	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.729
A0A1L8EPZ7	ptch1	A0A1L8EPZ7	A0A1L8HYE8	E3 ubiquitin-protein ligase.	SSD domain-containing protein.	0.963
A0A1L8EPZ7	ptch1-2	A0A1L8EPZ7	Q98SW6	E3 ubiquitin-protein ligase.	Patched-1.	0.963
A0A1L8EPZ7	ptch2	A0A1L8EPZ7	Q6IRA5	E3 ubiquitin-protein ligase.	SSD domain-containing protein.	0.955
A0A1L8EPZ7	ptch2-2	A0A1L8EPZ7	Q9DEF3	E3 ubiquitin-protein ligase.	Patched-2.	0.955
A0A1L8EPZ7	smurf2	A0A1L8EPZ7	A0A1L8ENB0	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.729
A0A1L8EV30	A0A1L8EPZ7	A0A1L8EV30	A0A1L8EPZ7	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.729
A0A1L8EV30	Smurf1.L	A0A1L8EV30	A0A1L8EX82	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.729
A0A1L8EV30	ptch1	A0A1L8EV30	A0A1L8HYE8	E3 ubiquitin-protein ligase.	SSD domain-containing protein.	0.963
A0A1L8EV30	ptch1-2	A0A1L8EV30	Q98SW6	E3 ubiquitin-protein ligase.	Patched-1.	0.963
A0A1L8EV30	ptch2	A0A1L8EV30	Q6IRA5	E3 ubiquitin-protein ligase.	SSD domain-containing protein.	0.955