(48 nodes) Intestinal immune network for IgA production network (Xenopus laevis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	map3k14	Protein kinase domain-containing protein. (892 aa)
	A0A1L8EME5	Uncharacterized protein. (328 aa)
	cxcr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	Itga4.S	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1073 aa)
	cd28	Uncharacterized protein. (210 aa)
	Map3k14.L	Protein kinase domain-containing protein. (902 aa)
	cd40	TNFR-Cys domain-containing protein. (280 aa)
	Cxcr4.L	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	itga4	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1027 aa)
	cd28-2	Uncharacterized protein. (209 aa)
	A0A1L8EWY0	Ig-like domain-containing protein. (208 aa)
	Cd40lg.S	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (273 aa)
	Mhc2a.S	Ig-like domain-containing protein. (248 aa)
	tgfb1	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	cd40lg	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (279 aa)
	A0A1L8F8C4	Ig-like domain-containing protein. (269 aa)
	hla-dqa2	Ig-like domain-containing protein. (250 aa)
	ElaDAB-A	Ig-like domain-containing protein. (261 aa)
	A0A1L8F8H2	Ig-like domain-containing protein. (258 aa)
	tgfb1-2	Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
	Aicda.S	CMP/dCMP-type deaminase domain-containing protein. (275 aa)
	A0A1L8FE12	Uncharacterized protein. (179 aa)
	Cxcl12.S	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	Aicda.L	CMP/dCMP-type deaminase domain-containing protein. (196 aa)
	cxcl12	SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
	A0A1L8FW11	Uncharacterized protein. (139 aa)
	ccr9	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	A0A1L8H3Q9	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (314 aa)
	cd86	Uncharacterized protein. (321 aa)
	A0A1L8H5T3	Uncharacterized protein. (286 aa)
	il10	Uncharacterized protein. (172 aa)
	A0A1L8HBQ9	Uncharacterized protein. (303 aa)
	A0A1L8HBV7	IG domain-containing protein. (308 aa)
	A0A1L8HC23	Uncharacterized protein. (327 aa)
	il10-2	Uncharacterized protein. (170 aa)
	pigr	Ig-like domain-containing protein. (593 aa)
	itgb7	Integrin beta; Belongs to the integrin beta chain family. (766 aa)
	A0A1L8HLT4	Interleukin; Belongs to the IL-15/IL-21 family. (168 aa)
	A0A1L8HUQ8	Uncharacterized protein. (136 aa)
	A0A1L8HYW0	Uncharacterized protein. (453 aa)
	A0A1L8HZ50	Ig-like domain-containing protein. (127 aa)
	tra	Ig-like domain-containing protein. (121 aa)
	A0A1L8I2F9	SCY domain-containing protein. (139 aa)
	A0A310TLK6	Ig-like domain-containing protein. (158 aa)
	A0A310U2Z2	Ig-like domain-containing protein. (142 aa)
	A0A310U7G4	Ig-like domain-containing protein. (250 aa)
	Q20FD2_XENLA	Class II MHC DM beta. (261 aa)
	tnfsf13b	BAFF; Belongs to the tumor necrosis factor family. (266 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EME5	A0A1L8EWY0	A0A1L8EME5	A0A1L8EWY0	Uncharacterized protein.	Ig-like domain-containing protein.	0.545
A0A1L8EME5	A0A1L8FW11	A0A1L8EME5	A0A1L8FW11	Uncharacterized protein.	Uncharacterized protein.	0.456
A0A1L8EME5	A0A1L8HC23	A0A1L8EME5	A0A1L8HC23	Uncharacterized protein.	Uncharacterized protein.	0.523
A0A1L8EME5	Cd40lg.S	A0A1L8EME5	A0A1L8F3A9	Uncharacterized protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.993
A0A1L8EME5	Map3k14.L	A0A1L8EME5	A0A1L8ESB9	Uncharacterized protein.	Protein kinase domain-containing protein.	0.406
A0A1L8EME5	cd40	A0A1L8EME5	A0A1L8ETV2	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.901
A0A1L8EME5	cd40lg	A0A1L8EME5	A0A1L8F817	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.993
A0A1L8EME5	cd86	A0A1L8EME5	A0A1L8H5I5	Uncharacterized protein.	Uncharacterized protein.	0.523
A0A1L8EME5	map3k14	A0A1L8EME5	A0A1L8EL46	Uncharacterized protein.	Protein kinase domain-containing protein.	0.406
A0A1L8EME5	tnfsf13b	A0A1L8EME5	R9U5E4	Uncharacterized protein.	BAFF; Belongs to the tumor necrosis factor family.	0.685
A0A1L8EWY0	A0A1L8EME5	A0A1L8EWY0	A0A1L8EME5	Ig-like domain-containing protein.	Uncharacterized protein.	0.545
A0A1L8EWY0	A0A1L8H5T3	A0A1L8EWY0	A0A1L8H5T3	Ig-like domain-containing protein.	Uncharacterized protein.	0.959
A0A1L8EWY0	A0A1L8HBQ9	A0A1L8EWY0	A0A1L8HBQ9	Ig-like domain-containing protein.	Uncharacterized protein.	0.959
A0A1L8EWY0	A0A1L8HC23	A0A1L8EWY0	A0A1L8HC23	Ig-like domain-containing protein.	Uncharacterized protein.	0.578
A0A1L8EWY0	Cd40lg.S	A0A1L8EWY0	A0A1L8F3A9	Ig-like domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.648
A0A1L8EWY0	cd28	A0A1L8EWY0	A0A1L8EPR7	Ig-like domain-containing protein.	Uncharacterized protein.	0.813
A0A1L8EWY0	cd28-2	A0A1L8EWY0	A0A1L8EWT1	Ig-like domain-containing protein.	Uncharacterized protein.	0.813
A0A1L8EWY0	cd40	A0A1L8EWY0	A0A1L8ETV2	Ig-like domain-containing protein.	TNFR-Cys domain-containing protein.	0.633
A0A1L8EWY0	cd40lg	A0A1L8EWY0	A0A1L8F817	Ig-like domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.648
A0A1L8EWY0	cd86	A0A1L8EWY0	A0A1L8H5I5	Ig-like domain-containing protein.	Uncharacterized protein.	0.578