115 items (Xenopus laevis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L8EKE2	Signal transducer and activator of transcription. (760 aa)
	A0A1L8EKH9	STAT_int domain-containing protein. (635 aa)
	Pck1.S	Uncharacterized protein. (622 aa)
	Socs3.S	Uncharacterized protein. (250 aa)
	g6pc.3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	G6pc.S	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
	Stat3.2.L	Signal transducer and activator of transcription. (760 aa)
	stat3.1	Signal transducer and activator of transcription. (769 aa)
	A0A1L8ES86	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
	Prkag3-b	Uncharacterized protein. (340 aa)
	Nfkbia.S	ANK_REP_REGION domain-containing protein. (312 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	Traf2.S	TNF receptor-associated factor. (461 aa)
	A0A1L8F189	Uncharacterized protein. (483 aa)
	A0A1L8F1V8	Protein kinase domain-containing protein. (246 aa)
	Acsl4.S	AMP-binding domain-containing protein. (670 aa)
	Irs4.S	Uncharacterized protein. (1088 aa)
	tnf	TNF_2 domain-containing protein. (227 aa)
	MGC78893	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (527 aa)
	rxra	Uncharacterized protein. (488 aa)
	irs4	Uncharacterized protein. (1077 aa)
	acsl4	AMP-binding domain-containing protein. (670 aa)
	rxrb	Uncharacterized protein. (459 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	Nfkbia.L	ANK_REP_REGION domain-containing protein. (315 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	A0A1L8FG16	Uncharacterized protein. (559 aa)
	socs3l	Uncharacterized protein. (215 aa)
	A0A1L8FHH3	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
	acsl5	AMP-binding domain-containing protein. (683 aa)
	tnfrsf1a	Uncharacterized protein. (422 aa)
	A0A1L8FKW5	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2533 aa)
	A0A1L8FND6	Uncharacterized protein. (232 aa)
	Prkag1.S	Uncharacterized protein. (521 aa)
	npy	Uncharacterized protein. (97 aa)
	A0A1L8FV68	Uncharacterized protein. (519 aa)
	nfkbie	ANK_REP_REGION domain-containing protein. (349 aa)
	A0A1L8G4J8	Uncharacterized protein. (1123 aa)
	acsl3	AMP-binding domain-containing protein. (803 aa)
	adipoq	C1q domain-containing protein. (233 aa)
	pomc	Uncharacterized protein. (260 aa)
	Nfkbie.L	ANK_REP_REGION domain-containing protein. (349 aa)
	Irs1.S	Uncharacterized protein. (1227 aa)
	acsl3-2	Uncharacterized protein. (709 aa)
	Pomc.L	Uncharacterized protein. (282 aa)
	rela	RHD_dimer domain-containing protein. (309 aa)
	A0A1L8GD66	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (778 aa)
	agrp	Agouti domain-containing protein. (147 aa)
	A0A1L8GFI4	Non-specific serine/threonine protein kinase. (551 aa)
	prkab2	AMPKBI domain-containing protein. (271 aa)
	A0A1L8GJ97	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (778 aa)
	rela-2	RHD domain-containing protein. (527 aa)
	agrp-2	Agouti domain-containing protein. (147 aa)
	tradd	Death domain-containing protein. (303 aa)
	A0A1L8GM16	Non-specific serine/threonine protein kinase. (551 aa)
	A0A1L8GM23	Uncharacterized protein. (1150 aa)
	Rxrg.L	Uncharacterized protein. (470 aa)
	cd36	Uncharacterized protein; Belongs to the CD36 family. (476 aa)
	Acsl6.L	AMP-binding domain-containing protein. (731 aa)
	cd36-2	Uncharacterized protein; Belongs to the CD36 family. (468 aa)
	Prkcq.L	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa)
	lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	Cpt1b.L	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
	acsbg1	AMP-binding domain-containing protein. (662 aa)
	ikbkb	Uncharacterized protein. (769 aa)
	A0A1L8H482	Uncharacterized protein. (814 aa)
	Slc2a4.L	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	A0A1L8H929	Uncharacterized protein. (1008 aa)
	A0A1L8HDZ2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (408 aa)
	adipor1	Uncharacterized protein. (401 aa)
	A0A1L8HH28	Uncharacterized protein. (1011 aa)
	Prkag2.L	Uncharacterized protein. (346 aa)
	ppargc1a	RRM domain-containing protein. (784 aa)
	Acsl1.S	Uncharacterized protein. (728 aa)
	Nfkb1.S	Uncharacterized protein. (894 aa)
	stk11	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	acsbg2	AMP-binding domain-containing protein. (737 aa)
	A0A1L8HPG1	Uncharacterized protein. (604 aa)
	Prkab1.S	AMPKBI domain-containing protein. (337 aa)
	A0A1L8HQP7	Protein kinase domain-containing protein. (558 aa)
	ppargc1a-2	RRM domain-containing protein. (786 aa)
	Nfkb1.L	Uncharacterized protein. (959 aa)
	mapk10-2	Mitogen-activated protein kinase. (444 aa)
	stk11-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	Acsbg2.L	AMP-binding domain-containing protein. (756 aa)
	jak2	Tyrosine-protein kinase. (1129 aa)
	A0A1L8HZX3	Uncharacterized protein. (2426 aa)
	A0A1L8I0A7	AMPKBI domain-containing protein. (266 aa)
	A0A1L8I158	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	A0A1L8I1C0	Protein kinase domain-containing protein. (556 aa)
	Jak2.S	Tyrosine-protein kinase. (1088 aa)
	tnf-2	Tumor necrosis factor alpha. (225 aa)
	tnfrsf1a-2	Tumor necrosis factor receptor 1. (412 aa)
	MGC115510	MGC115510 protein. (471 aa)
	lep-2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (560 aa)
	slc2a1	LOC494763 protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
	g6pc	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	npy-2	MGC86288 protein. (97 aa)
	adipor2	MGC85478 protein. (385 aa)
	ppara	Ppara protein. (474 aa)
	adipoq-2	MGC84292 protein. (235 aa)
	ptpn11b	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	rxrb-2	Rxrb protein. (449 aa)
	socs3	MGC81248 protein. (199 aa)
	g6pc-2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
	g6pc.3-2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	g6pc-3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	prkab2-2	Prkab2-prov protein. (271 aa)
	pck1	Pck1-prov protein. (622 aa)
	cpt1al	MGC53498 protein; Belongs to the carnitine/choline acetyltransferase family. (768 aa)
	adipor1-2	Adipor1-prov protein. (381 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (560 aa)
	Ptpn11.S	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)

Your Current Organism:

Xenopus laevis

NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L8EKE2	A0A1L8FND6	A0A1L8EKE2	A0A1L8FND6	Signal transducer and activator of transcription.	Uncharacterized protein.	0.450
A0A1L8EKE2	Jak2.S	A0A1L8EKE2	A0A310U8T2	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.984
A0A1L8EKE2	Ptpn11.S	A0A1L8EKE2	Q92124	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	Socs3.S	A0A1L8EKE2	A0A1L8EM41	Signal transducer and activator of transcription.	Uncharacterized protein.	0.517
A0A1L8EKE2	ikbkb	A0A1L8EKE2	A0A1L8H261	Signal transducer and activator of transcription.	Uncharacterized protein.	0.501
A0A1L8EKE2	jak2	A0A1L8EKE2	A0A1L8HY58	Signal transducer and activator of transcription.	Tyrosine-protein kinase.	0.988
A0A1L8EKE2	lep	A0A1L8EKE2	A0A1L8GZQ3	Signal transducer and activator of transcription.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.569
A0A1L8EKE2	lep-2	A0A1L8EKE2	Q563I5	Signal transducer and activator of transcription.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.569
A0A1L8EKE2	ptpn11b	A0A1L8EKE2	Q6GP31	Signal transducer and activator of transcription.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.471
A0A1L8EKE2	socs3	A0A1L8EKE2	Q6NU49	Signal transducer and activator of transcription.	MGC81248 protein.	0.518
A0A1L8EKE2	socs3l	A0A1L8EKE2	A0A1L8FH19	Signal transducer and activator of transcription.	Uncharacterized protein.	0.450
A0A1L8EKH9	A0A1L8FG16	A0A1L8EKH9	A0A1L8FG16	STAT_int domain-containing protein.	Uncharacterized protein.	0.567
A0A1L8EKH9	A0A1L8FKW5	A0A1L8EKH9	A0A1L8FKW5	STAT_int domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.622
A0A1L8EKH9	A0A1L8FND6	A0A1L8EKH9	A0A1L8FND6	STAT_int domain-containing protein.	Uncharacterized protein.	0.688
A0A1L8EKH9	A0A1L8I158	A0A1L8EKH9	A0A1L8I158	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.567
A0A1L8EKH9	Jak2.S	A0A1L8EKH9	A0A310U8T2	STAT_int domain-containing protein.	Tyrosine-protein kinase.	0.985
A0A1L8EKH9	Ptpn11.S	A0A1L8EKH9	Q92124	STAT_int domain-containing protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.610
A0A1L8EKH9	Socs3.S	A0A1L8EKH9	A0A1L8EM41	STAT_int domain-containing protein.	Uncharacterized protein.	0.703
A0A1L8EKH9	ikbkb	A0A1L8EKH9	A0A1L8H261	STAT_int domain-containing protein.	Uncharacterized protein.	0.505
A0A1L8EKH9	jak2	A0A1L8EKH9	A0A1L8HY58	STAT_int domain-containing protein.	Tyrosine-protein kinase.	0.985