STRINGSTRING
rpsH rpsH topA topA hemA hemA mcsB mcsB rpsB rpsB AIT90295.1 AIT90295.1 AIT90296.1 AIT90296.1 AIT90298.1 AIT90298.1 AIT90300.1 AIT90300.1 AIT90308.1 AIT90308.1 AIT90318.1 AIT90318.1 pckG pckG AIT90331.1 AIT90331.1 AIT90338.1 AIT90338.1 AIT90346.1 AIT90346.1 AIT90347.1 AIT90347.1 AIT90354.1 AIT90354.1 AIT90377.1 AIT90377.1 priA priA rpmJ rpmJ rpsN rpsN dnaG dnaG rplY rplY rpsF rpsF rpsR rpsR ispE ispE AIT90408.1 AIT90408.1 AIT90410.1 AIT90410.1 AIT90427.1 AIT90427.1 rpmI rpmI rplT rplT rpsO rpsO tadA tadA AIT90446.1 AIT90446.1 AIT90461.1 AIT90461.1 rpmE2 rpmE2 rpsP rpsP rplS rplS AIT90521.1 AIT90521.1 recF recF rpmB rpmB ychF ychF AIT91090.1 AIT91090.1 rplM rplM rpsI rpsI adk adk AIT90610.1 AIT90610.1 rpmG rpmG AIT90640.1 AIT90640.1 AIT91097.1 AIT91097.1 ubiX ubiX recR recR pdhA pdhA AIT90701.1 AIT90701.1 AIT90711.1 AIT90711.1 AIT90720.1 AIT90720.1 atpB atpB rplL rplL rplJ rplJ rplA rplA rplK rplK AIT90787.1 AIT90787.1 AIT90791.1 AIT90791.1 rpsU rpsU rnz rnz AIT90827.1 AIT90827.1 AIT90834.1 AIT90834.1 AIT90853.1 AIT90853.1 rplU rplU ybeY ybeY rpsJ rpsJ rpsG rpsG rpsL rpsL AIT90903.1 AIT90903.1 AIT90904.1 AIT90904.1 truA truA recO recO AIT90914.1 AIT90914.1 AIT90918.1 AIT90918.1 hemH hemH AIT90938.1 AIT90938.1 rplQ rplQ rpsK rpsK rpsM rpsM rplO rplO rpsE rpsE rplR rplR rplF rplF rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC AIT90974.1 AIT90974.1 AIT90991.1 AIT90991.1 AIT91130.1 AIT91130.1 AIT91021.1 AIT91021.1 AIT91022.1 AIT91022.1 rpsT rpsT nfo nfo rpsD rpsD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (865 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (333 aa)
mcsBATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. (356 aa)
rpsB30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS2 family. (280 aa)
AIT90295.1TPR repeat-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AIT90296.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
AIT90298.1ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
AIT90300.1Chromosome partitioning protein ParB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ParB family. (280 aa)
AIT90308.1Endonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
AIT90318.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1163 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (599 aa)
AIT90331.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
AIT90338.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AIT90346.1Lysine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
AIT90347.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
AIT90354.1Protoporphyrinogen oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (424 aa)
AIT90377.1Myosin heavy chain; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (753 aa)
rpmJ50S ribosomal protein L36; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL36 family. (45 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (600 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (185 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (112 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (81 aa)
ispE4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (283 aa)
AIT90408.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
AIT90410.1Glycerol-3-phosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AIT90427.1Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology. (975 aa)
rpmI50S ribosomal protein L35; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL35 family. (64 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (123 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
tadACytidine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (157 aa)
AIT90446.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (92 aa)
AIT90461.1Low calcium response protein H; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
rpmE250S ribosomal protein L31; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
rpsP30S ribosomal protein S16; Binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bS16 family. (116 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (121 aa)
AIT90521.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (365 aa)
rpmB50S ribosomal protein L28; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL28 family. (89 aa)
ychFGTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (364 aa)
AIT91090.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (295 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (150 aa)
rpsI30S ribosomal protein S9; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS9 family. (133 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (253 aa)
AIT90610.1Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (614 aa)
rpmG50S ribosomal protein L33; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bL33 family. (52 aa)
AIT90640.1Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (145 aa)
AIT91097.1Magnesium transporter; Acts as a magnesium transporter. (470 aa)
ubiXAromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (192 aa)
recRRecombinase RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (200 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (340 aa)
AIT90701.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
AIT90711.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
AIT90720.1Integration host factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial histone-like protein family. (100 aa)
atpBATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (438 aa)
rplL50S ribosomal protein L7; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (130 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (172 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (232 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
AIT90787.1Nucleoid-associated protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (96 aa)
AIT90791.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (678 aa)
rpsU30S ribosomal protein S21; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (304 aa)
AIT90827.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AIT90834.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AIT90853.1Molecular chaperone DnaK; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (107 aa)
ybeYrRNA maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (158 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (105 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (157 aa)
rpsL30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (123 aa)
AIT90903.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
AIT90904.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
truAPseudouridine synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (267 aa)
recODNA recombination protein RecO; Involved in DNA repair and RecF pathway recombination. (234 aa)
AIT90914.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AIT90918.1DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (318 aa)
AIT90938.1DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (472 aa)
rplQ50S ribosomal protein L17; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (132 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (165 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (123 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (183 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (111 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (83 aa)
rpmC50S ribosomal protein L29; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL29 family. (72 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (138 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (224 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (111 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (88 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (284 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (111 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (222 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (221 aa)
AIT90974.1acyl-CoA thioester hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
AIT90991.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1199 aa)
AIT91130.1Regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (639 aa)
AIT91021.1Regulator of sigma subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (602 aa)
AIT91022.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (956 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (98 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (288 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (209 aa)
Your Current Organism:
Chlamydia muridarum
NCBI taxonomy Id: 83560
Other names: ATCC VR-123, C. muridarum, Chlamydia trachomatis MoPn, agent of mouse pneumonitis, strain MoPn, strain Nigg, strain Nigg II
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