STRINGSTRING
DRC1 DRC1 gas8 gas8 ccdc103 ccdc103 SPAG1 SPAG1 pih1d3 pih1d3 ccdc40 ccdc40 dnaaf3 dnaaf3 rsph9 rsph9 dnaaf4 dnaaf4 LRRC56 LRRC56 dnai2 dnai2 CCDC65 CCDC65 dnaaf2 dnaaf2 LOC108648942 LOC108648942 cfap298 cfap298 ttc12 ttc12 rsph1 rsph1 zmynd10 zmynd10 SPEF2 SPEF2 ccdc39 ccdc39 dnaaf1 dnaaf1 cfap300 cfap300 DNAAF5 DNAAF5 rsph6a rsph6a lrrc6 lrrc6 dnah9 dnah9 dnali1 dnali1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRC1Dynein regulatory complex subunit 1. (612 aa)
gas8GAS domain-containing protein. (484 aa)
ccdc103Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. (247 aa)
SPAG1Sperm associated antigen 1. (941 aa)
pih1d3Eukaryotic peptide chain release factor subunit 1. (190 aa)
ccdc40Uncharacterized protein. (607 aa)
dnaaf3Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity); Belongs to the DNAAF3 family. (493 aa)
rsph9Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. (145 aa)
dnaaf4Uncharacterized protein. (412 aa)
LRRC56Leucine rich repeat containing 56. (622 aa)
dnai22-oxoglutarate and iron-dependent oxygenase domain-containing protein 3. (611 aa)
CCDC65Coiled-coil domain containing 65. (490 aa)
dnaaf2Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily. (785 aa)
LOC108648942Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4. (191 aa)
cfap298Uncharacterized protein. (290 aa)
ttc12TPR_REGION domain-containing protein. (714 aa)
rsph1Uncharacterized protein. (189 aa)
zmynd10Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. Belongs to the ZMYND10 family. (455 aa)
SPEF2Sperm flagellar 2. (1648 aa)
ccdc39Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly; Belongs to the CCDC39 family. (945 aa)
dnaaf1Dynein assembly factor 1, axonemal. (612 aa)
cfap300Cilia- and flagella-associated protein 300; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly; Belongs to the CFAP300 family. (267 aa)
DNAAF5Dynein axonemal assembly factor 5. (849 aa)
rsph6aRadial spoke head protein 6 homolog A; Belongs to the flagellar radial spoke RSP4/6 family. (523 aa)
lrrc6Protein tilB homolog; May play a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. May be required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules (By similarity); Belongs to the tilB family. (519 aa)
dnah9Myosin, heavy chain 2, skeletal muscle, adult. (4295 aa)
dnali1Uncharacterized protein. (259 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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