STRINGSTRING
wdr19 wdr19 wdr19-2 wdr19-2 RPGRIP1L RPGRIP1L ttc30a ttc30a rpgrip1 rpgrip1 nphp3 nphp3 usb1 usb1 nphp4.2 nphp4.2 slc6a19-2 slc6a19-2 tmem17 tmem17 ift43 ift43 b9d1 b9d1 ift52 ift52 ift46 ift46 tctn3 tctn3 TTC21A TTC21A b9d2 b9d2 IFT88 IFT88 ENSXETP00000021574 ENSXETP00000021574 ift140 ift140 ift57 ift57 AHI1 AHI1 nek6 nek6 ENSXETP00000025007 ENSXETP00000025007 anks3 anks3 cluap1 cluap1 cc2d2a cc2d2a tmem237 tmem237 nphp1 nphp1 WDR35 WDR35 LOC100135070 LOC100135070 mks1 mks1 tmem67 tmem67 ift27 ift27 ttc26 ttc26 iqcb1 iqcb1 tmem216 tmem216 def6-2 def6-2 ift80 ift80 anks6 anks6 c11orf74 c11orf74 tctn1 tctn1 nek8 nek8 ift81 ift81 LOC100489231 LOC100489231 ift74 ift74 hspb11 hspb11 tmem231 tmem231 CEP290 CEP290 TMEM107 TMEM107 LOC100485117 LOC100485117 invs invs ift122 ift122 TTC21B TTC21B traf3ip1 traf3ip1 ift22 ift22 ift20 ift20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wdr19Uncharacterized protein. (837 aa)
wdr19-2Cyclin-dependent kinase 8. (1298 aa)
RPGRIP1LRPGRIP1 like. (1266 aa)
ttc30aTetratricopeptide repeat protein 30A; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (651 aa)
rpgrip1Myelin regulatory factor. (1279 aa)
nphp3Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements (By similarity). (1266 aa)
usb1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (251 aa)
nphp4.2Vac14 homolog. (1439 aa)
slc6a19-2Solute carrier family 6 (neutral amino acid transporter), member 19. (396 aa)
tmem17Transmembrane protein 17B; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (219 aa)
ift43Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. (201 aa)
b9d1B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (203 aa)
ift52Achaete-scute family bHLH transcription factor 2. (452 aa)
ift46Taste 2 receptor member 7. (419 aa)
tctn3DUF1619 domain-containing protein. (515 aa)
TTC21ATetratricopeptide repeat domain 21A. (1312 aa)
b9d2Cadherin 13. (176 aa)
IFT88Intraflagellar transport 88. (826 aa)
ENSXETP00000021574Uncharacterized protein. (170 aa)
ift140Uncharacterized protein. (1461 aa)
ift57Intraflagellar transport protein 57 homolog; Required for the formation of cilia. May also have pro- apoptotic function (By similarity); Belongs to the IFT57 family. (411 aa)
AHI1Abelson helper integration site 1. (747 aa)
nek6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (312 aa)
ENSXETP00000025007Uncharacterized protein. (63 aa)
anks3Nipsnap homolog 2. (650 aa)
cluap1Uncharacterized protein. (425 aa)
cc2d2a7-dehydrocholesterol reductase. (1599 aa)
tmem237Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity); Belongs to the TMEM237 family. (387 aa)
nphp1Nuclear factor I C. (687 aa)
WDR35WD repeat-containing protein 35. (1181 aa)
LOC100135070SH3-domain-binding protein 2. (309 aa)
mks1Heterogeneous nuclear ribonucleoprotein R. (555 aa)
tmem67Sideroflexin 5. (989 aa)
ift27Uncharacterized protein. (210 aa)
ttc26Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme. (554 aa)
iqcb1Uncharacterized protein. (594 aa)
tmem216Polycystin 1, transient receptor potential channel interacting. (143 aa)
def6-2DEF6, guanine nucleotide exchange factor. (366 aa)
ift80Intraflagellar transport 80 homolog. (779 aa)
anks6Uncharacterized protein. (903 aa)
c11orf74Uncharacterized protein. (204 aa)
tctn1Adaptor related protein complex 3 subunit sigma 2. (693 aa)
nek8Protein kinase domain-containing protein. (726 aa)
ift81Transportin 1. (674 aa)
LOC100489231Isochorismatase domain-containing protein 2. (1702 aa)
ift74Intraflagellar transport 74 homolog. (601 aa)
hspb11Novel protein similar to c1orf41. (139 aa)
tmem231Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (312 aa)
CEP290Centrosomal protein 290. (2365 aa)
TMEM107Transmembrane protein 107. (140 aa)
LOC100485117Uncharacterized protein. (340 aa)
invsANK_REP_REGION domain-containing protein. (1004 aa)
ift122Intraflagellar transport protein 122 homolog; Required for cilia formation during embryonal development. Acts as a negative regulator of Shh signaling. (1222 aa)
TTC21BTetratricopeptide repeat domain 21B. (1334 aa)
traf3ip1Uncharacterized protein. (628 aa)
ift22Intraflagellar transport protein 22 homolog; Belongs to the small GTPase superfamily. Rab family. (184 aa)
ift20Intraflagellar transport protein 20 homolog; Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. (132 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.