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actr3 actr3 actb actb twf1 twf1 gmfg gmfg arpc2 arpc2 cfl1 cfl1 arpc1a arpc1a arpc5l arpc5l SCRN3 SCRN3 gmfb gmfb actg1 actg1 PFN4 PFN4 ssh3 ssh3 gpbar1 gpbar1 wdr1 wdr1 dstn dstn actr2 actr2 limk1 limk1 arpc1b arpc1b LOC100488540 LOC100488540 arpc5 arpc5 ehmt1-2 ehmt1-2 arpc3 arpc3 SSH1 SSH1 limk2 limk2 nckipsd nckipsd cap1 cap1 pfn2 pfn2 coro1c coro1c STAC2 STAC2 coro6 coro6 LOC101732697 LOC101732697 CAP2 CAP2 dbnl dbnl ssh2 ssh2 scrn2 scrn2 cfl2 cfl2 mybph mybph wasl wasl
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
actr3Calreticulin 3; Belongs to the actin family. (597 aa)
actbActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
twf1Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (353 aa)
gmfgADF-H domain-containing protein. (61 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
cfl1Cofilin-1; May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage furrow during cytokinesis. (168 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (381 aa)
arpc5lActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (152 aa)
SCRN3Secernin 3. (438 aa)
gmfbGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (143 aa)
actg1Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
PFN4Profilin; Belongs to the profilin family. (128 aa)
ssh3RAN binding protein 1. (688 aa)
gpbar1G_PROTEIN_RECEP_F1_2 domain-containing protein. (334 aa)
wdr1WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity); Belongs to the WD repeat AIP1 family. (609 aa)
dstnSolute carrier family 1 member 2; Belongs to the actin-binding proteins ADF family. (153 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and r [...] (399 aa)
limk1Uncharacterized protein. (618 aa)
arpc1bActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (383 aa)
LOC100488540Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (357 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
ehmt1-2Uncharacterized protein. (207 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (181 aa)
SSH1Slingshot protein phosphatase 1. (975 aa)
limk2Exocyst complex component 6. (585 aa)
nckipsdADP ribosylation factor like GTPase 1. (743 aa)
cap1Adenylyl cyclase-associated protein; Belongs to the CAP family. (556 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
coro1cCoronin; Belongs to the WD repeat coronin family. (751 aa)
STAC2SH3 and cysteine rich domain 2. (405 aa)
coro6Coronin; Belongs to the WD repeat coronin family. (471 aa)
LOC101732697G protein-coupled receptor 158. (209 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (483 aa)
dbnlAdaptor related protein complex 2 subunit sigma 1. (455 aa)
ssh2FERM and PDZ domain containing 3. (1419 aa)
scrn2Secernin-2; Belongs to the peptidase C69 family. Secernin subfamily. (446 aa)
cfl2Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (167 aa)
mybphMyosin binding protein H. (507 aa)
waslWiskott-Aldrich syndrome-like. (511 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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