(49 nodes) Mixed, incl. Retromer complex, and COMM domain network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	stk19	Ribosomal protein S17. (260 aa)
	commd2	LOC100127739 protein. (199 aa)
	vps35l	Proprotein convertase subtilisin/kexin type 7. (963 aa)
	washc1	WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (472 aa)
	vps26a	Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). (329 aa)
	washc3	DEAH-box helicase 33. (199 aa)
	galns-2	Galactosamine (N-acetyl)-6-sulfatase. (784 aa)
	vps35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
	ccdc93	Coiled-coil domain-containing protein 93; May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family. (330 aa)
	snx17	Uncharacterized protein. (254 aa)
	commd8	Ependymin related 1. (189 aa)
	snx5	Sorting nexin; Involved in several stages of intracellular trafficking. (406 aa)
	ing5-2	Inhibitor of growth family member 5. (115 aa)
	washc2a	CAP-ZIP_m domain-containing protein. (1037 aa)
	washc4	Matrix metallopeptidase 24. (1174 aa)
	ENSXETP00000017096	PX domain-containing protein. (104 aa)
	snx30	Sorting nexin-30; May be involved in several stages of intracellular trafficking. (484 aa)
	SNX27	Sorting nexin 27. (389 aa)
	Dact3	Uncharacterized protein. (347 aa)
	OTULIN	OTU deubiquitinase with linear linkage specificity. (541 aa)
	ccdc22	Coiled-coil domain-containing protein 22; May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity). (632 aa)
	snx10	Seryl-tRNA synthetase 2, mitochondrial. (171 aa)
	SNX1	Sorting nexin 1. (581 aa)
	hs1bp3	PX domain-containing protein. (412 aa)
	SNX8	Sorting nexin 8. (432 aa)
	SH3PXD2A	SH3 and PX domains 2A. (1111 aa)
	vps26b	Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). (338 aa)
	snx31	Sorting nexin-31; May be involved in protein trafficking. (409 aa)
	snx12	PX domain-containing protein. (237 aa)
	snx21	PX domain-containing protein. (386 aa)
	zdhhc14	Zinc finger DHHC-type containing 14. (332 aa)
	FAM13B	Family with sequence similarity 13 member B. (831 aa)
	ENSXETP00000034924	PX domain-containing protein. (101 aa)
	snx3	Sorting nexin 12. (162 aa)
	vps26c	BAI1-associated protein 2. (318 aa)
	commd9	LOC496905 protein. (198 aa)
	vps29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...] (182 aa)
	commd10	Prostaglandin E synthase 2. (199 aa)
	SNX2	Sorting nexin 2. (523 aa)
	pxk	Protein Spindly. (726 aa)
	tc2n	Cryptochrome circadian regulator 1. (474 aa)
	fkbp15	Peptidylprolyl isomerase. (1245 aa)
	commd5	COMM domain-containing protein. (223 aa)
	commd1	Protein serine kinase H1. (187 aa)
	snx7	Sorting nexin 7. (441 aa)
	COMMD3	COMM domain containing 3. (195 aa)
	snx6	Sorting nexin; Involved in several stages of intracellular trafficking. (407 aa)
	tbc1d5	Protein S. (773 aa)
	washc5	WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. (1159 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COMMD3	ccdc22	ENSXETP00000050487	ENSXETP00000021730	COMM domain containing 3.	Coiled-coil domain-containing protein 22; May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).	0.839
COMMD3	ccdc93	ENSXETP00000050487	ENSXETP00000011654	COMM domain containing 3.	Coiled-coil domain-containing protein 93; May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family.	0.760
COMMD3	commd1	ENSXETP00000050487	ENSXETP00000046046	COMM domain containing 3.	Protein serine kinase H1.	0.800
COMMD3	commd10	ENSXETP00000050487	ENSXETP00000037591	COMM domain containing 3.	Prostaglandin E synthase 2.	0.878
COMMD3	commd2	ENSXETP00000050487	ENSXETP00000001819	COMM domain containing 3.	LOC100127739 protein.	0.905
COMMD3	commd5	ENSXETP00000050487	ENSXETP00000044202	COMM domain containing 3.	COMM domain-containing protein.	0.678
COMMD3	commd8	ENSXETP00000050487	ENSXETP00000015127	COMM domain containing 3.	Ependymin related 1.	0.656
COMMD3	commd9	ENSXETP00000050487	ENSXETP00000036623	COMM domain containing 3.	LOC496905 protein.	0.862
COMMD3	vps26c	ENSXETP00000050487	ENSXETP00000036590	COMM domain containing 3.	BAI1-associated protein 2.	0.728
COMMD3	vps29	ENSXETP00000050487	ENSXETP00000037461	COMM domain containing 3.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...]	0.565
COMMD3	vps35l	ENSXETP00000050487	ENSXETP00000002366	COMM domain containing 3.	Proprotein convertase subtilisin/kexin type 7.	0.727
Dact3	SNX8	ENSXETP00000020334	ENSXETP00000026664	Uncharacterized protein.	Sorting nexin 8.	0.530
ENSXETP00000017096	SNX1	ENSXETP00000017096	ENSXETP00000024351	PX domain-containing protein.	Sorting nexin 1.	0.439
ENSXETP00000017096	SNX2	ENSXETP00000017096	ENSXETP00000038293	PX domain-containing protein.	Sorting nexin 2.	0.414
ENSXETP00000017096	galns-2	ENSXETP00000017096	ENSXETP00000009743	PX domain-containing protein.	Galactosamine (N-acetyl)-6-sulfatase.	0.465
ENSXETP00000017096	vps26a	ENSXETP00000017096	ENSXETP00000005413	PX domain-containing protein.	Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).	0.484
ENSXETP00000017096	vps26b	ENSXETP00000017096	ENSXETP00000027198	PX domain-containing protein.	Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity).	0.484
ENSXETP00000017096	vps26c	ENSXETP00000017096	ENSXETP00000036590	PX domain-containing protein.	BAI1-associated protein 2.	0.469
ENSXETP00000017096	vps29	ENSXETP00000017096	ENSXETP00000037461	PX domain-containing protein.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...]	0.517
ENSXETP00000017096	vps35	ENSXETP00000017096	ENSXETP00000011203	PX domain-containing protein.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.531

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