STRINGSTRING
LOC100495326 LOC100495326 tmed7 tmed7 irak1 irak1 mfap4 mfap4 tirap tirap ENSXETP00000017211 ENSXETP00000017211 LOC100491693 LOC100491693 tlr3 tlr3 LOC101734746 LOC101734746 irak4 irak4 tollip tollip trmt2b trmt2b ctdsp2-2 ctdsp2-2 sigirr sigirr LOC101733659 LOC101733659 tent5b-2 tent5b-2 tlr8 tlr8 LOC100489423 LOC100489423 myd88 myd88 irak2 irak2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100495326Cytochrome P450 family 27 subfamily B member 1; Belongs to the Toll-like receptor family. (781 aa)
tmed7Serine incorporator 2. (225 aa)
irak1Peroxisomal membrane protein PEX16. (760 aa)
mfap4Pancreatic lipase-related protein 3. (881 aa)
tirapTIR domain-containing protein. (547 aa)
ENSXETP00000017211TIR domain-containing protein; Belongs to the Toll-like receptor family. (826 aa)
LOC100491693TIR domain-containing protein. (505 aa)
tlr3TIR domain-containing protein; Belongs to the Toll-like receptor family. (917 aa)
LOC101734746Uncharacterized protein. (870 aa)
irak4Irak4 protein. (457 aa)
tollipToll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (272 aa)
trmt2btRNA methyltransferase 2 homolog B. (786 aa)
ctdsp2-2CTD small phosphatase 2; Belongs to the Toll-like receptor family. (790 aa)
sigirrSingle Ig and TIR domain containing. (327 aa)
LOC101733659TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (559 aa)
tent5b-2Terminal nucleotidyltransferase 5B. (185 aa)
tlr8Tetratricopeptide repeat domain 21B; Belongs to the Toll-like receptor family. (1036 aa)
LOC100489423ADAM metallopeptidase domain 23. (652 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (283 aa)
irak2NOP2/Sun RNA methyltransferase family member 7. (666 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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