(48 nodes) Receptor signaling pathway via STAT, and Cytokine receptor activity network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	clcf1	Cardiotrophin-like cytokine factor 1. (223 aa)
	il27ra	Uncharacterized protein. (473 aa)
	ifnar2.1	Fibronectin type-III domain-containing protein. (498 aa)
	ifngr2.2	Lactamase beta. (337 aa)
	ywhag-2	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma. (190 aa)
	btg5.1	Novel protein similar to BTG family, member 3 btg3. (196 aa)
	stat4	Signal transducer and activator of transcription. (689 aa)
	TYK2	Tyrosine-protein kinase. (1195 aa)
	socs3l	Suppressor of cytokine signaling 3. (211 aa)
	il22	Interleukin-22. (192 aa)
	LOC105945198	Type I interferon 4. (189 aa)
	npas4-2	Neuronal PAS domain protein 4. (181 aa)
	stat3.2	STAT_int domain-containing protein. (408 aa)
	stat3.1	Signal transducer and activator of transcription. (715 aa)
	il11ra	Fibronectin type-III domain-containing protein. (249 aa)
	NFAT5	Nuclear factor of activated T cells 5. (1464 aa)
	FOXP3	Forkhead box P3. (412 aa)
	ifnl3	Monoamine oxidase A. (179 aa)
	il10	Activating transcription factor 6. (172 aa)
	Il6	Uncharacterized protein. (150 aa)
	Cntf	Uncharacterized protein. (171 aa)
	LOC101734966	Uncharacterized protein. (179 aa)
	socs3	Suppressor of cytokine signaling 3. (199 aa)
	il10rb	Fibronectin type-III domain-containing protein. (308 aa)
	ifngr2.1	Uncharacterized protein. (311 aa)
	ifnar1	Uncharacterized protein. (642 aa)
	stat1	Signal transducer and activator of transcription. (751 aa)
	abca4-3	ATP binding cassette subfamily A member 4. (174 aa)
	crlf1	Mitochondrial E3 ubiquitin protein ligase 1. (387 aa)
	rex1bd	Uncharacterized protein. (150 aa)
	nup153-2	Amine oxidase, copper containing 1. (291 aa)
	il22-2	Pre-mRNA processing factor 4B. (175 aa)
	il11	Uncharacterized protein. (186 aa)
	ifnlr1	Interferon lambda receptor transcript variant 3. (497 aa)
	ifngr1	Uncharacterized protein. (433 aa)
	ENSXETP00000035129	Interleukin 20 receptor subunit alpha. (568 aa)
	LIFR	LIF receptor subunit alpha. (1009 aa)
	irf9	RAS protein activator like 3. (434 aa)
	stat6	Signal transducer and activator of transcription. (787 aa)
	IL6ST	Interleukin 6 signal transducer. (948 aa)
	ebi3	Beta-1,4-glucuronyltransferase 1. (188 aa)
	jak3	Tyrosine-protein kinase. (1107 aa)
	il4r	Mesenteric estrogen-dependent adipogenesis. (934 aa)
	JAK1	Tyrosine-protein kinase. (1142 aa)
	il13ra2	Tetratricopeptide repeat domain 16. (397 aa)
	il13ra1	Cleavage stimulation factor, 3' pre-RNA, subunit 1. (357 aa)
	jak2	Tyrosine-protein kinase. (1129 aa)
	stat2	Signal transducer and activator of transcription. (765 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cntf	IL6ST	ENSXETP00000024819	ENSXETP00000038203	Uncharacterized protein.	Interleukin 6 signal transducer.	0.946
Cntf	Il6	ENSXETP00000024819	ENSXETP00000024453	Uncharacterized protein.	Uncharacterized protein.	0.578
Cntf	LIFR	ENSXETP00000024819	ENSXETP00000035240	Uncharacterized protein.	LIF receptor subunit alpha.	0.916
Cntf	abca4-3	ENSXETP00000024819	ENSXETP00000028683	Uncharacterized protein.	ATP binding cassette subfamily A member 4.	0.604
Cntf	clcf1	ENSXETP00000024819	ENSXETP00000001596	Uncharacterized protein.	Cardiotrophin-like cytokine factor 1.	0.561
Cntf	ebi3	ENSXETP00000024819	ENSXETP00000038501	Uncharacterized protein.	Beta-1,4-glucuronyltransferase 1.	0.510
Cntf	il11	ENSXETP00000024819	ENSXETP00000031872	Uncharacterized protein.	Uncharacterized protein.	0.595
Cntf	il11ra	ENSXETP00000024819	ENSXETP00000019702	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.510
Cntf	il27ra	ENSXETP00000024819	ENSXETP00000003285	Uncharacterized protein.	Uncharacterized protein.	0.485
Cntf	npas4-2	ENSXETP00000024819	ENSXETP00000015873	Uncharacterized protein.	Neuronal PAS domain protein 4.	0.568
Cntf	nup153-2	ENSXETP00000024819	ENSXETP00000031022	Uncharacterized protein.	Amine oxidase, copper containing 1.	0.510
ENSXETP00000035129	ifnar1	ENSXETP00000035129	ENSXETP00000026732	Interleukin 20 receptor subunit alpha.	Uncharacterized protein.	0.556
ENSXETP00000035129	ifnlr1	ENSXETP00000035129	ENSXETP00000033712	Interleukin 20 receptor subunit alpha.	Interferon lambda receptor transcript variant 3.	0.506
ENSXETP00000035129	il10rb	ENSXETP00000035129	ENSXETP00000026665	Interleukin 20 receptor subunit alpha.	Fibronectin type-III domain-containing protein.	0.597
ENSXETP00000035129	il13ra1	ENSXETP00000035129	ENSXETP00000049179	Interleukin 20 receptor subunit alpha.	Cleavage stimulation factor, 3' pre-RNA, subunit 1.	0.438
ENSXETP00000035129	il13ra2	ENSXETP00000035129	ENSXETP00000046446	Interleukin 20 receptor subunit alpha.	Tetratricopeptide repeat domain 16.	0.444
ENSXETP00000035129	il22	ENSXETP00000035129	ENSXETP00000009708	Interleukin 20 receptor subunit alpha.	Interleukin-22.	0.555
ENSXETP00000035129	il22-2	ENSXETP00000035129	ENSXETP00000031834	Interleukin 20 receptor subunit alpha.	Pre-mRNA processing factor 4B.	0.974
FOXP3	Il6	ENSXETP00000021791	ENSXETP00000024453	Forkhead box P3.	Uncharacterized protein.	0.606
FOXP3	NFAT5	ENSXETP00000021791	ENSXETP00000020412	Forkhead box P3.	Nuclear factor of activated T cells 5.	0.597

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