(6 nodes) Mixed, incl. TRIF-dependent toll-like receptor signaling pathway, and Inter-alpha-trypsin inhibitor heavy chain, C-terminal network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	itih5-2	Leucine rich repeat containing 41. (180 aa)
	cd40	CD40. (279 aa)
	tnfrsf9	TNFR-Cys domain-containing protein. (177 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (269 aa)
	grpel2-2	GrpE like 2, mitochondrial. (254 aa)
	CD276	CD276 molecule. (332 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD276	CD40LG	ENSXETP00000053454	ENSXETP00000050349	CD276 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.594
CD276	cd40	ENSXETP00000053454	ENSXETP00000012304	CD276 molecule.	CD40.	0.474
CD276	itih5-2	ENSXETP00000053454	ENSXETP00000003930	CD276 molecule.	Leucine rich repeat containing 41.	0.647
CD276	tnfrsf9	ENSXETP00000053454	ENSXETP00000034379	CD276 molecule.	TNFR-Cys domain-containing protein.	0.587
CD40LG	CD276	ENSXETP00000050349	ENSXETP00000053454	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD276 molecule.	0.594
CD40LG	cd40	ENSXETP00000050349	ENSXETP00000012304	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD40.	0.994
CD40LG	itih5-2	ENSXETP00000050349	ENSXETP00000003930	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Leucine rich repeat containing 41.	0.641
CD40LG	tnfrsf9	ENSXETP00000050349	ENSXETP00000034379	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TNFR-Cys domain-containing protein.	0.708
cd40	CD276	ENSXETP00000012304	ENSXETP00000053454	CD40.	CD276 molecule.	0.474
cd40	CD40LG	ENSXETP00000012304	ENSXETP00000050349	CD40.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.994
cd40	itih5-2	ENSXETP00000012304	ENSXETP00000003930	CD40.	Leucine rich repeat containing 41.	0.645
cd40	tnfrsf9	ENSXETP00000012304	ENSXETP00000034379	CD40.	TNFR-Cys domain-containing protein.	0.703
grpel2-2	itih5-2	ENSXETP00000053309	ENSXETP00000003930	GrpE like 2, mitochondrial.	Leucine rich repeat containing 41.	0.760
itih5-2	CD276	ENSXETP00000003930	ENSXETP00000053454	Leucine rich repeat containing 41.	CD276 molecule.	0.647
itih5-2	CD40LG	ENSXETP00000003930	ENSXETP00000050349	Leucine rich repeat containing 41.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.641
itih5-2	cd40	ENSXETP00000003930	ENSXETP00000012304	Leucine rich repeat containing 41.	CD40.	0.645
itih5-2	grpel2-2	ENSXETP00000003930	ENSXETP00000053309	Leucine rich repeat containing 41.	GrpE like 2, mitochondrial.	0.760
itih5-2	tnfrsf9	ENSXETP00000003930	ENSXETP00000034379	Leucine rich repeat containing 41.	TNFR-Cys domain-containing protein.	0.537
tnfrsf9	CD276	ENSXETP00000034379	ENSXETP00000053454	TNFR-Cys domain-containing protein.	CD276 molecule.	0.587
tnfrsf9	CD40LG	ENSXETP00000034379	ENSXETP00000050349	TNFR-Cys domain-containing protein.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.708

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