STRINGSTRING
arnt arnt Crtc2 Crtc2 atcay-2 atcay-2 RXFP1 RXFP1 ep300 ep300 cry1 cry1 npas4 npas4 grk3 grk3 CRY2 CRY2 creb1 creb1 rxrg rxrg LOC549154 LOC549154 pparg pparg sik2 sik2 ppargc1b ppargc1b esr2 esr2 hif1an hif1an siah3 siah3 per3 per3 esrrb esrrb ENSXETP00000015861 ENSXETP00000015861 PPARG PPARG ppara ppara ncoa2 ncoa2 nr1h2 nr1h2 znf420-2 znf420-2 sp1 sp1 cry4 cry4 egln2 egln2 ar ar nr1d1 nr1d1 csnk1g1 csnk1g1 arntl arntl ovos2-3 ovos2-3 ncoa1 ncoa1 fbxl3 fbxl3 clock clock per2 per2 bhlhe41 bhlhe41 rora rora csnk1d csnk1d esrrg esrrg nr1h5 nr1h5 rxra rxra ncoa5 ncoa5 ahrr ahrr crtc3 crtc3 sim2 sim2 esrra esrra aipl1 aipl1 ENSXETP00000037774 ENSXETP00000037774 hlx hlx ppargc1a ppargc1a sim1 sim1 epas1 epas1 Hif1a Hif1a csnk1e csnk1e thibz thibz NCOA3 NCOA3 gper1 gper1 per1 per1 cry-dash cry-dash aip aip nrip1 nrip1 phr phr hadh-3 hadh-3 bhlhe40 bhlhe40 atf1 atf1 ahr ahr esr1 esr1 rxrb rxrb egln1 egln1 fbxo32-2 fbxo32-2 arnt2 arnt2 VDR VDR npas3 npas3 egln3 egln3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
arntRas homolog, mTORC1 binding. (778 aa)
Crtc2TORC_N domain-containing protein. (54 aa)
atcay-2Ataxia, cerebellar, Cayman type. (686 aa)
RXFP1Relaxin family peptide receptor 1. (714 aa)
ep300Suv3 like RNA helicase. (2493 aa)
cry1Forkhead box protein F1. (616 aa)
npas4Npas4 protein. (721 aa)
grk3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (707 aa)
CRY2Cryptochrome circadian regulator 2. (662 aa)
creb1DET1, COP1 ubiquitin ligase partner. (341 aa)
rxrgGlutamate receptor interacting protein 2. (535 aa)
LOC549154Uncharacterized protein. (354 aa)
ppargPeroxisome proliferator activated receptor gamma. (327 aa)
sik2Syntaxin 12. (916 aa)
ppargc1bAcylphosphatase-1. (937 aa)
esr2Estrogen receptor 2 (ER beta). (548 aa)
hif1anHypoxia-inducible factor 1, alpha subunit inhibitor. (352 aa)
siah3E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (241 aa)
per3Integrin linked kinase. (1258 aa)
esrrbMitogen-activated protein kinase kinase kinase 2. (441 aa)
ENSXETP00000015861Uncharacterized protein. (470 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (192 aa)
pparaLysosomal-associated membrane protein 1. (474 aa)
ncoa2Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required in a nuclear receptor pathway to suppress expression of dorsal mesoderm genes. May play a role in the positive regulation of the circadian clock. (1509 aa)
nr1h2Nuclear receptor subfamily 1, group H, member 2. (441 aa)
znf420-2Zinc finger protein 420. (128 aa)
sp1Nuclear receptor subfamily 2 group E member 3. (747 aa)
cry4WD repeat containing, antisense to TP73. (567 aa)
egln2T-box protein VegT. (454 aa)
arTransforming acidic coiled-coil containing protein 3. (788 aa)
nr1d1Heparan sulfate 6-O-sulfotransferase 3. (529 aa)
csnk1g1Zinc finger protein 605. (461 aa)
arntlSin3A associated protein 18kDa. (513 aa)
ovos2-3Alpha-2-macroglobulin like 1 pseudogene. (2368 aa)
ncoa1Nuclear receptor coactivator. (1479 aa)
fbxl3RAB8A, member RAS oncogene family. (464 aa)
clockKIAA1324. (850 aa)
per2Arginase 2. (1410 aa)
bhlhe41Uncharacterized protein. (403 aa)
roraPotassium channel, two pore domain subfamily K, member 4. (518 aa)
csnk1dCasein kinase I isoform delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (441 aa)
esrrgUncharacterized protein. (501 aa)
nr1h5Nuclear receptor subfamily 1, group H, member 5. (513 aa)
rxraParalemmin. (498 aa)
ncoa5Nuclear receptor coactivator 5. (625 aa)
ahrrLeucine rich repeat and Ig domain containing 3. (753 aa)
crtc3CREB-regulated transcription coactivator 3; Transcriptional coactivator for creb1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of creb1 'Ser-119' phosphorylation. Enhances the interaction of creb1 with taf4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of ppargc1a and inducer of mitochondrial biogenesis in muscle cells (By similarity). (658 aa)
sim2NACHT and WD repeat domain-containing 1. (751 aa)
esrraRho-related BTB domain-containing 3. (408 aa)
aipl1Far upstream element binding protein 1. (333 aa)
ENSXETP00000037774Uncharacterized protein. (148 aa)
hlxCytosol aminopeptidase. (328 aa)
ppargc1aLETM1 domain-containing protein LETM2, mitochondrial. (810 aa)
sim1Coagulation factor V (proaccelerin, labile factor). (763 aa)
epas1Uncharacterized protein. (873 aa)
Hif1aKIAA1211. (830 aa)
csnk1eDEAD-box helicase 24. (516 aa)
thibzChoroideremia (Rab escort protein 1). (335 aa)
NCOA3Nuclear receptor coactivator 3. (1364 aa)
gper1Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa)
per1PAS domain-containing protein. (914 aa)
cry-dashFamily with sequence similarity 92 member B. (445 aa)
aipAryl hydrocarbon receptor interacting protein. (328 aa)
nrip1Rho guanine nucleotide exchange factor 12. (1138 aa)
phrEndo-beta-N-acetylglucosaminidase. (291 aa)
hadh-3Photolyase/cryptochrome alpha/beta domain-containing protein. (106 aa)
bhlhe40ADAMTS like 4. (226 aa)
atf1Activating transcription factor 1. (281 aa)
ahrUncharacterized protein. (843 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (585 aa)
rxrbUncharacterized protein. (464 aa)
egln1EGL nine homolog 2 (C. elegans). (394 aa)
fbxo32-2Sorting nexin-31. (489 aa)
arnt2Uncharacterized protein. (730 aa)
VDRVitamin D receptor. (420 aa)
npas3Uncharacterized protein. (949 aa)
egln3Protein phosphatase, Mg2+/Mn2+ dependent 1A. (252 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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