STRINGSTRING
SHC1 SHC1 PDGFC PDGFC fgf1 fgf1 ngf ngf fgf13 fgf13 Prg4 Prg4 pik3cb pik3cb LOC100485272 LOC100485272 fgf16 fgf16 LOC105947943 LOC105947943 sos2 sos2 EGFR EGFR pik3r2 pik3r2 CD34 CD34 HBEGF HBEGF kctd1 kctd1 rapgef1 rapgef1 cd79a cd79a lcp2 lcp2 ptk7 ptk7 ptpn11 ptpn11 LOC733728 LOC733728 BTC BTC VEGFD VEGFD LOC101731237 LOC101731237 efna1 efna1 fgf3 fgf3 egf egf btk btk zup1-2 zup1-2 FGF5 FGF5 THY1 THY1 VEGFC VEGFC PIK3R1 PIK3R1 snai2 snai2 nedd4 nedd4 cbl cbl grap grap sos1 sos1 GRAP2 GRAP2 ntrk1 ntrk1 fgfr2 fgfr2 gab2 gab2 ENSXETP00000018188 ENSXETP00000018188 ptpn6 ptpn6 IRS2 IRS2 esam esam pdgfb-2 pdgfb-2 hck hck srms srms LOC100491469 LOC100491469 fgf8 fgf8 slc25a18 slc25a18 adtrp adtrp vegfa vegfa cblb cblb angpt1 angpt1 ins ins pecam1 pecam1 IGF1R IGF1R fgf20 fgf20 fgf9 fgf9 bdnf bdnf irs4 irs4 PDGFRB PDGFRB sox9 sox9 ETV6 ETV6 LOC100491788 LOC100491788 csk csk IGF1 IGF1 RD3 RD3 fgfbp1 fgfbp1 tgfa tgfa mmp2 mmp2 ptpn11b ptpn11b nradd nradd vav3 vav3 kit kit ntf4 ntf4 frs2-2 frs2-2 ENSXETP00000031154 ENSXETP00000031154 epgn epgn ereg ereg areg areg GTF2I GTF2I flt4 flt4 pdgfra pdgfra IRS1 IRS1 cdh5 cdh5 LOC101730699 LOC101730699 shc2 shc2 fgf19 fgf19 irs2 irs2 cblc cblc SORT1 SORT1 nrg1 nrg1 cspg4 cspg4 pgr pgr GAB1 GAB1 syk syk fgf23.2 fgf23.2 fgf10 fgf10 shc3 shc3 fgf6 fgf6 ptpn1 ptpn1 GRB7 GRB7 snai1 snai1 lyn lyn TEC TEC rnf41 rnf41 fgfr4 fgfr4 vav2 vav2 atg9a-2 atg9a-2 TEK TEK fgf12 fgf12 pdgfa pdgfa kdrl kdrl papolg-2 papolg-2 vav1 vav1 PLCG2 PLCG2 PDGFD PDGFD kitlg kitlg pik3ca pik3ca erbb2 erbb2 PSTPIP1 PSTPIP1 ERBB4 ERBB4 twist1 twist1 itch itch grb2 grb2 ntrk2 ntrk2 ntf3 ntf3 INSR INSR met met fgfr3 fgfr3 NGFR NGFR fgfrl1 fgfrl1 fgfr1 fgfr1 matk matk ptpn12 ptpn12 pik3r3 pik3r3 HGF HGF ERBB3 ERBB3 fgf7 fgf7 USP8 USP8 PAG1 PAG1 sh2b2 sh2b2 wwp1 wwp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC1SHC adaptor protein 1. (431 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ngfRibonuclease H2 subunit A; Belongs to the NGF-beta family. (231 aa)
fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
Prg4Uncharacterized protein. (949 aa)
pik3cbSolute carrier family 27 member 6; Belongs to the PI3/PI4-kinase family. (1085 aa)
LOC100485272Fibrinogen C-terminal domain-containing protein. (503 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
LOC105947943Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
sos2Ornithine carbamoyltransferase. (1333 aa)
EGFRReceptor protein-tyrosine kinase. (1216 aa)
pik3r2Uncharacterized protein. (719 aa)
CD34Uncharacterized protein. (329 aa)
HBEGFHeparin binding EGF like growth factor. (195 aa)
kctd1Potassium channel tetramerization domain containing 1. (302 aa)
rapgef1Uncharacterized protein. (1233 aa)
cd79aUrocanate hydratase 1. (239 aa)
lcp2LOC100158590 protein. (504 aa)
ptk7Protein tyrosine kinase 7 (inactive). (697 aa)
ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
LOC7337285'-aminolevulinate synthase 1. (142 aa)
BTCBetacellulin. (170 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (333 aa)
LOC101731237Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
efna1Ephrin RBD domain-containing protein; Belongs to the ephrin family. (146 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa)
egfUncharacterized protein. (1051 aa)
btkTyrosine-protein kinase. (649 aa)
zup1-2Zinc finger containing ubiquitin peptidase 1. (2282 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
THY1Thy-1 cell surface antigen. (136 aa)
VEGFCVascular endothelial growth factor C. (407 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (718 aa)
snai2Snail homolog 2 (Drosophila). (266 aa)
nedd4E3 ubiquitin-protein ligase. (896 aa)
cblUncharacterized protein. (954 aa)
grapUncharacterized protein. (219 aa)
sos1Organic solute transporter subunit alpha. (1329 aa)
GRAP2GRB2 related adaptor protein 2. (218 aa)
ntrk1Tyrosine-protein kinase receptor. (808 aa)
fgfr2Fibroblast growth factor receptor. (834 aa)
gab2Growth factor receptor bound protein 2-associated protein 2. (679 aa)
ENSXETP00000018188SH2 domain-containing protein. (66 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (601 aa)
IRS2Insulin receptor substrate 2. (1006 aa)
esamArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (438 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
hckTyrosine-protein kinase. (489 aa)
srmsTyrosine-protein kinase. (478 aa)
LOC100491469Tyrosine-protein kinase. (493 aa)
fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
slc25a18Slc25a18 protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (304 aa)
adtrpB cell linker. (235 aa)
vegfaGID complex subunit 8; Belongs to the PDGF/VEGF growth factor family. (311 aa)
cblbE3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (982 aa)
angpt1PWWP domain-containing protein 2A. (504 aa)
insInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
pecam1Uncharacterized protein. (726 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (247 aa)
irs4Zinc finger MYND-type containing 19. (1077 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1015 aa)
sox9Transcription factor Sox-9; Transcription activator. Acts early in neural crest formation, functioning redundantly with the other group E Sox factors sox8 and sox10 to induce neural crest progenitors. Induces sox10 expression downstream of wnt-signaling. Principally involved in development of the cranial neural crest, which is fated to form skeletal elements. Also required for otic placode specification during inner ear development (By similarity). May be involved in chondrogenesis (cartilage development) during bone formation. Unlikely to play a role in sex determination but may funct [...] (482 aa)
ETV6ETS variant 6. (409 aa)
LOC100491788Calcium channel, voltage-dependent, beta 3 subunit. (724 aa)
cskTyrosine-protein kinase. (456 aa)
IGF1Insulin like growth factor 1. (153 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (217 aa)
fgfbp1Protein phosphatase, Mg2+/Mn2+ dependent 1L. (224 aa)
tgfaSolute carrier family 6 (neurotransmitter transporter), member 8 like. (163 aa)
mmp2Paired box 6. (685 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
nraddHigh mobility group box 3. (390 aa)
vav3General transcription factor IIH subunit 4. (821 aa)
kitMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
ntf4RAD50 homolog, double strand break repair protein; Belongs to the NGF-beta family. (236 aa)
frs2-2Frs2 protein. (509 aa)
ENSXETP00000031154B cell linker. (489 aa)
epgnLeucine-rich repeats and calponin homology (CH) domain containing 1. (138 aa)
eregNIMA-related kinase 6. (156 aa)
aregEGF-like domain-containing protein. (226 aa)
GTF2IGeneral transcription factor IIi. (904 aa)
flt4Transient receptor potential cation channel subfamily M member 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1364 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1096 aa)
IRS1Insulin receptor substrate 1. (1120 aa)
cdh5Zinc finger RNA-binding protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
LOC101730699Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3. (331 aa)
shc2Uncharacterized protein. (631 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
irs2Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or grb2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). (554 aa)
cblcUncharacterized protein. (425 aa)
SORT1Sortilin. (801 aa)
nrg1GATA zinc finger domain containing 2A. (621 aa)
cspg4Dual-specificity tyrosine-phosphorylation-regulated kinase 1A. (2183 aa)
pgrUncharacterized protein. (731 aa)
GAB1GRB2 associated binding protein 1. (672 aa)
sykTyrosine-protein kinase. (611 aa)
fgf23.2Leucine-rich repeat LGI family member 4; Belongs to the heparin-binding growth factors family. (254 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
shc3Optic atrophy 1 (autosomal dominant). (625 aa)
fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
ptpn1Tyrosine-protein phosphatase non-receptor type. (449 aa)
GRB7Growth factor receptor bound protein 7. (615 aa)
snai1Uncharacterized protein. (336 aa)
lynTyrosine-protein kinase. (524 aa)
TECTyrosine-protein kinase. (641 aa)
rnf41Bardet-Biedl syndrome 5. (317 aa)
fgfr4Fibroblast growth factor receptor. (833 aa)
vav2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2. (914 aa)
atg9a-2Autophagy related 9A. (148 aa)
TEKTEK receptor tyrosine kinase. (1114 aa)
fgf12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
pdgfaUncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (308 aa)
kdrlUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1015 aa)
papolg-2Poly(A) polymerase gamma. (466 aa)
vav1V-rel avian reticuloendotheliosis viral oncogene homolog. (836 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (389 aa)
kitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (277 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
erbb2Receptor protein-tyrosine kinase. (1316 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (411 aa)
ERBB4Receptor protein-tyrosine kinase. (1291 aa)
twist1RAB34, member RAS oncogene family. (166 aa)
itchE3 ubiquitin-protein ligase. (853 aa)
grb2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation. (229 aa)
ntrk2Tyrosine-protein kinase receptor. (821 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (274 aa)
INSRTyrosine-protein kinase receptor. (1360 aa)
metUTP6 small subunit processome component. (1402 aa)
fgfr3Fibroblast growth factor receptor. (829 aa)
NGFRNerve growth factor receptor. (398 aa)
fgfrl1Propionyl-CoA carboxylase subunit alpha. (479 aa)
fgfr1Fibroblast growth factor receptor. (827 aa)
matkTyrosine-protein kinase. (496 aa)
ptpn12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (709 aa)
pik3r3Phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (461 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1347 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1058 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (440 aa)
sh2b2Ubiquitin conjugating enzyme E2 D3. (666 aa)
wwp1E3 ubiquitin-protein ligase. (914 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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