STRINGSTRING
pip5k1a pip5k1a pip4p1 pip4p1 ENSXETP00000004514 ENSXETP00000004514 adamts2 adamts2 cdipt cdipt snapc5 snapc5 MTMR4 MTMR4 pi4k2a pi4k2a MINPP1 MINPP1 pten pten LOC100494483 LOC100494483 prkca prkca snx33 snx33 LOC100494672 LOC100494672 ENSXETP00000013981 ENSXETP00000013981 snx9 snx9 ric1-2 ric1-2 pi4ka pi4ka ocrl ocrl cnot3-3 cnot3-3 synj2 synj2 pip4k2c pip4k2c PPIP5K1 PPIP5K1 ITPKB ITPKB ENSXETP00000021565 ENSXETP00000021565 ippk ippk vac14 vac14 sacm1l sacm1l prkcg prkcg itpkc itpkc synj1 synj1 LOC100144987 LOC100144987 maco1-2 maco1-2 ENSXETP00000025702 ENSXETP00000025702 mtmr6 mtmr6 MTMR3 MTMR3 PIP5KL1 PIP5KL1 IPMK IPMK pheta2 pheta2 dipk2a dipk2a pikfyve pikfyve top1mt top1mt clpx-2 clpx-2 pi4k2b pi4k2b MTMR2 MTMR2 nlk.2-2 nlk.2-2 inpp5j inpp5j pik3c2a pik3c2a ENSXETP00000034327 ENSXETP00000034327 ENSXETP00000035306 ENSXETP00000035306 wdr81 wdr81 FIG4 FIG4 fchsd1 fchsd1 snx18 snx18 INPP4B INPP4B PIP5K1B PIP5K1B mtm1 mtm1 snapc1 snapc1 ip6k2 ip6k2 inpp5a.1 inpp5a.1 mtmr1 mtmr1 snapc3 snapc3 inpp5k inpp5k PLCG1 PLCG1 PPIP5K2 PPIP5K2 fam214a fam214a plcd1 plcd1 itpk1 itpk1 zfand2a zfand2a wdr91 wdr91 inpp4a inpp4a pip4k2a pip4k2a itpka itpka plcd4 plcd4 pip4k2b pip4k2b itpr3 itpr3 pip5k1c pip5k1c ip6k1 ip6k1 ENSXETP00000052531 ENSXETP00000052531 inpp5e inpp5e gpr135 gpr135 INPP5B INPP5B pip4p2 pip4p2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pip5k1aPIPK domain-containing protein. (468 aa)
pip4p1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (327 aa)
ENSXETP00000004514IPPc domain-containing protein. (375 aa)
adamts2ADAM metallopeptidase with thrombospondin type 1 motif 2. (449 aa)
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (218 aa)
snapc5Uncharacterized protein. (95 aa)
MTMR4Myotubularin related protein 4. (1093 aa)
pi4k2aPhosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). (474 aa)
MINPP1Multiple inositol-polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family. (483 aa)
ptenPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
LOC100494483Endoribonuclease LACTB2. (256 aa)
prkcaR3H domain and coiled-coil-containing 1-like; Belongs to the protein kinase superfamily. (261 aa)
snx33Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking, both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity). (549 aa)
LOC100494672SERTA domain containing 2. (296 aa)
ENSXETP00000013981IPPc domain-containing protein. (387 aa)
snx9Sorting nexin. (585 aa)
ric1-2RIC1 homolog, RAB6A GEF complex partner 1. (378 aa)
pi4kaCordon-bleu WH2 repeat protein; Belongs to the PI3/PI4-kinase family. (2088 aa)
ocrlHairy and enhancer of split 5, gene 2. (909 aa)
cnot3-3CCR4-NOT transcription complex subunit 3. (378 aa)
synj2Scavenger receptor class B member 1. (1551 aa)
pip4k2cPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2). (484 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1361 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (655 aa)
ENSXETP00000021565IPPc domain-containing protein. (361 aa)
ippkInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (489 aa)
vac14Uncharacterized protein. (782 aa)
sacm1lSAC domain-containing protein. (586 aa)
prkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
itpkcKinase; Belongs to the inositol phosphokinase (IPK) family. (518 aa)
synj1Stathmin 3. (1548 aa)
LOC100144987Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (390 aa)
maco1-2Macoilin 1. (378 aa)
ENSXETP00000025702IPPc domain-containing protein. (358 aa)
mtmr6Zinc finger protein 362. (727 aa)
MTMR3Myotubularin related protein 3. (1224 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (477 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (399 aa)
pheta2PH domain containing endocytic trafficking adaptor 2. (249 aa)
dipk2aDivergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family. (431 aa)
pikfyveUncharacterized protein. (2104 aa)
top1mtPhosphoinositide phospholipase C. (1368 aa)
clpx-2Caseinolytic mitochondrial matrix peptidase chaperone subunit. (525 aa)
pi4k2bPhosphatidylinositol 4-kinase type 2-beta; Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5- bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity); Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. (537 aa)
MTMR2Myotubularin related protein 2. (596 aa)
nlk.2-2Serine/threonine-protein kinase NLK2. (513 aa)
inpp5jCalcium channel, voltage-dependent, T type, alpha 1I subunit. (767 aa)
pik3c2aUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1714 aa)
ENSXETP00000034327PH domain-containing protein. (171 aa)
ENSXETP00000035306PH domain-containing protein. (231 aa)
wdr81F-box/LRR-repeat protein 15. (1888 aa)
FIG4FIG4 phosphoinositide 5-phosphatase. (741 aa)
fchsd1Cartilage intermediate layer protein 2. (665 aa)
snx18Sorting nexin. (586 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (972 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (585 aa)
mtm1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). (602 aa)
snapc1Small nuclear RNA activating complex, polypeptide 1, 43kDa. (364 aa)
ip6k2Kinase; Belongs to the inositol phosphokinase (IPK) family. (429 aa)
inpp5a.1Inositol polyphosphate-5-phosphatase, 40kDa. (432 aa)
mtmr1Myotubularin phosphatase domain-containing protein. (690 aa)
snapc3Serine/threonine kinase-like domain containing 1. (377 aa)
inpp5kIPPc domain-containing protein. (547 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1269 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1257 aa)
fam214aProtein FAM214A; Belongs to the FAM214 family. (946 aa)
plcd1Phosphoinositide phospholipase C. (786 aa)
itpk1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (396 aa)
zfand2aNovel protein containing AN1-like Zinc finger and Ubiquitin interaction motif. (259 aa)
wdr91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa)
inpp4aUncharacterized protein. (972 aa)
pip4k2aChromosome 11 open reading frame 54. (470 aa)
itpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (470 aa)
plcd4Phosphoinositide phospholipase C. (758 aa)
pip4k2bLaeverin. (426 aa)
itpr3Inositol (1,4,5) trisphosphate receptor type 3. (2673 aa)
pip5k1cPIPK domain-containing protein. (688 aa)
ip6k1Kinase; Belongs to the inositol phosphokinase (IPK) family. (412 aa)
ENSXETP00000052531Glycyl-tRNA synthetase. (986 aa)
inpp5eMajor histocompatibility complex class I antigen. (607 aa)
gpr135G protein-coupled receptor 135. (337 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (891 aa)
pip4p2Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (276 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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