STRINGSTRING
ASCL1 ASCL1 NEUROG3 NEUROG3 id3 id3 tle5 tle5 tle2 tle2 pax6 pax6 tbx18 tbx18 hes6.2 hes6.2 nkx6-1 nkx6-1 otx1 otx1 pou3f2 pou3f2 pdx1 pdx1 lhx8 lhx8 ascl2 ascl2 bsx bsx tcf3 tcf3 foxa2 foxa2 NKX2-2 NKX2-2 insm1 insm1 nes nes st6gal1-2 st6gal1-2 id2 id2 emx1-2 emx1-2 tcf12 tcf12 MYT1L MYT1L phox2b phox2b VSX2 VSX2 EVX1 EVX1 fezf2 fezf2 emx2 emx2 satb2 satb2 HNF1B HNF1B RFX6 RFX6 ENSXETP00000032512 ENSXETP00000032512 eya2 eya2 phox2a phox2a gsx1 gsx1 neurog2 neurog2 En1 En1 olig3 olig3 cux2 cux2 NR2E1 NR2E1 LOC100485335 LOC100485335 MNX1 MNX1 ATOH1 ATOH1 hnf1a hnf1a sox17a sox17a EYA4 EYA4 neurod6 neurod6 six3 six3 six2 six2 en2 en2 pou4f1.2 pou4f1.2 LOC100493338 LOC100493338 SIX4 SIX4 six1 six1 six6 six6 onecut1 onecut1 EYA1 EYA1 tle4 tle4 BARX2 BARX2 tle1 tle1 dach2 dach2 neurod2 neurod2 neurod1 neurod1 emx1 emx1 id4 id4 atoh7 atoh7 insm2 insm2 nkx1-1 nkx1-1 PTF1A PTF1A satb1 satb1 EVX2 EVX2 HOXD13 HOXD13 fezf1 fezf1 foxg1 foxg1 tbr1 tbr1 olig4 olig4 HNF4G HNF4G cux1 cux1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASCL1Achaete-scute family bHLH transcription factor 1. (191 aa)
NEUROG3Neurogenin 3. (226 aa)
id3DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Influences cell fate decisions in the embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions. Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes. Also inhibits the activity of neurog [...] (118 aa)
tle5Transducin-like enhancer of split 4 homolog of Drosophila E(Spl). (198 aa)
tle2tRNA methyltransferase 12 homolog. (769 aa)
pax6Uncharacterized protein. (456 aa)
tbx18Mgc107884 protein. (578 aa)
hes6.2Uncharacterized protein. (212 aa)
nkx6-1Meis homeobox 1. (348 aa)
otx1Homeobox domain-containing protein. (338 aa)
pou3f2POU domain protein. (382 aa)
pdx1Hepatocyte nuclear factor 4, beta. (271 aa)
lhx8LIM homeobox 7/8. (374 aa)
ascl2BHLH domain-containing protein. (169 aa)
bsxBsx protein. (229 aa)
tcf3BHLH domain-containing protein. (702 aa)
foxa2Forkhead box protein A2; Acts as a transcriptional activator during early development, limiting the extent of mesoderm formation in the gastrula. Binds to DNA via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the preferred binding site (By similarity). (434 aa)
NKX2-2NK2 homeobox 2. (271 aa)
insm1Insulinoma-associated protein 1; May act as a transcriptional regulator. Plays a role in noradrenergic neuron, pancreatic and gastrointestinal endocrine cells differentiation during embryonic development (By similarity). Belongs to the INSM1 family. (441 aa)
nesIF rod domain-containing protein; Belongs to the intermediate filament family. (1966 aa)
st6gal1-2ST6 beta-galactosamide alpha-2,6-sialyltranferase 1. (120 aa)
id2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock (By similarity). (132 aa)
emx1-2Homeobox protein EMX1; May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system; Belongs to the EMX homeobox family. (117 aa)
tcf12Metal transporter CNNM4. (701 aa)
MYT1LMyelin transcription factor 1 like. (1186 aa)
phox2bPolymerase (RNA) II (DNA directed) polypeptide A, 220kDa. (293 aa)
VSX2Visual system homeobox 2. (377 aa)
EVX1Even-skipped homeobox 1. (491 aa)
fezf2Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. (435 aa)
emx2WD repeat-containing protein 70. (247 aa)
satb2DNA-binding protein SATB. (765 aa)
HNF1BHNF1 homeobox B. (566 aa)
RFX6Regulatory factor X6. (931 aa)
ENSXETP00000032512Paired domain-containing protein. (163 aa)
eya2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (554 aa)
phox2aHomeobox domain-containing protein. (281 aa)
gsx1Kruppel-like factor 7 (ubiquitous). (243 aa)
neurog2Basonuclin 1. (213 aa)
En1Uncharacterized protein. (218 aa)
olig3Oligodendrocyte transcription factor 3. (263 aa)
cux2Homeobox protein cut-like. (1498 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (397 aa)
LOC100485335Poly(A) polymerase alpha. (281 aa)
MNX1Motor neuron and pancreas homeobox 1. (339 aa)
ATOH1Atonal bHLH transcription factor 1. (260 aa)
hnf1aHeterogeneous nuclear ribonucleoprotein U-like 1. (622 aa)
sox17aTranscription factor Sox-17-alpha; Transcription activator. Binds to the DNA sequence 5'-AACAAT- 3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling (By similarity). (383 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
neurod6Neurogenic differentiation factor. (337 aa)
six3Transmembrane protein 136. (295 aa)
six2Homeobox domain-containing protein. (287 aa)
en2Homeobox protein engrailed-like. (266 aa)
pou4f1.2POU domain protein. (412 aa)
LOC100493338Adrenoceptor alpha 1D. (206 aa)
SIX4SIX homeobox 4. (817 aa)
six1Six1 protein. (284 aa)
six6Homeobox domain-containing protein. (244 aa)
onecut1One cut domain family member. (493 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (636 aa)
tle4F-box and WD repeat domain containing 4. (774 aa)
BARX2BARX homeobox 2. (288 aa)
tle1Uncharacterized protein. (780 aa)
dach2Dach2 protein. (592 aa)
neurod2Neurogenic differentiation factor. (353 aa)
neurod1Neurogenic differentiation factor. (361 aa)
emx1Sortilin-related receptor, L(DLR class) A repeats containing. (213 aa)
id4DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurog1/neurogenin, neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors (By similarity). (131 aa)
atoh7Peptidylprolyl isomerase like 6. (139 aa)
insm26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (365 aa)
nkx1-1RPGR interacting protein 1. (408 aa)
PTF1APancreas associated transcription factor 1a. (320 aa)
satb1DNA-binding protein SATB. (753 aa)
EVX2Even-skipped homeobox 2. (512 aa)
HOXD13Homeobox D13. (300 aa)
fezf1Fez family zinc finger protein 1; Transcription repressor. Involved in the development of the forebrain region (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family. (462 aa)
foxg1Myb-related transcription factor, partner of profilin. (432 aa)
tbr1T-box_assoc domain-containing protein. (690 aa)
olig4Oligodendrocyte lineage transcription factor 2. (209 aa)
HNF4GHepatocyte nuclear factor 4 gamma. (463 aa)
cux1Homeobox protein cut-like. (1409 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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