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lmo4.2 lmo4.2 dlx6 dlx6 SHOX SHOX LHX2 LHX2 otx2 otx2 lypla1-2 lypla1-2 irx5 irx5 dlx2 dlx2 otp otp ssbp4 ssbp4 nr4a2 nr4a2 LMX1A LMX1A shox2 shox2 lmx1b.2 lmx1b.2 prrx1 prrx1 ldb1 ldb1 irx1 irx1 irx2 irx2 onecut1.2 onecut1.2 crx crx dlx5 dlx5 TBX15 TBX15 rax rax lhx9 lhx9 ldb2 ldb2 rorb rorb ssbp2 ssbp2 hhex hhex ISL1 ISL1 glis1 glis1 isl2 isl2 znf710 znf710 nhlh1 nhlh1 LHX6 LHX6 rax2 rax2 lmo4.1 lmo4.1 gabra3 gabra3 ENSXETP00000052435 ENSXETP00000052435 ZNF521 ZNF521
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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lmo4.2LIM domain transcription factor LMO4.1; Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity). (237 aa)
dlx6Sedoheptulokinase. (260 aa)
SHOXShort stature homeobox. (334 aa)
LHX2LIM homeobox 2. (419 aa)
otx2Homeobox protein OTX2; May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix- A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity); Belongs to the paired homeobox family. Bicoid subfamily. (289 aa)
lypla1-2Lysophospholipase 1. (410 aa)
irx5Iroquois-class homeodomain protein irx-5; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development. Involved in craniofacial and gonadal development (By similarity). Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. (486 aa)
dlx2Distal-less homeobox 2. (285 aa)
otpCKLF-like MARVEL transmembrane domain containing 4. (318 aa)
ssbp4Ceramide-1-phosphate transfer protein. (408 aa)
nr4a2Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons; Belongs to the nuclear hormone receptor family. (612 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (380 aa)
shox2Cartilage acidic protein 1. (311 aa)
lmx1b.2Decapping mRNA 1B. (374 aa)
prrx1L1 cell adhesion molecule. (248 aa)
ldb1LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. Acts as a coactivator together with otx2 to stimulate lhx1/lim1-mediated activation of the gsc promoter in the Spemann organizer. Acts synergistically with lhx1/lim1 and ssbp in axis formation (By similarity). (411 aa)
irx1Iroquois-class homeodomain protein irx-1; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up- regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds [...] (467 aa)
irx2Iroquois-class homeodomain protein irx-2; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up- regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Probably dispensable for pronephric kidney development. (479 aa)
onecut1.2One cut domain family member. (417 aa)
crxHomeobox protein otx5; Transcription factor involved in anterior and eye development. Promotes the differentiation of both rod and cone photoreceptors cells in the retina. Together with other retinal homeobox proteins, acts as an effector of a cellular clock which, depending on cell cycle progression, establishes the generation of distinct retinal neuronal cell types. Acts synergistically with nrl to activate the rhodopsin promoter. Promotes the formation of anterior regions and represses the formation of posterior structures during development (By similarity). (290 aa)
dlx5Nuclear factor of activated T cells 3. (298 aa)
TBX15T-box transcription factor 15. (601 aa)
raxUncharacterized protein. (326 aa)
lhx9mRNA decay activator protein ZFP36L2. (398 aa)
ldb2Claudin 8, gene 1. (397 aa)
rorbRadial spoke head protein 9 homolog. (505 aa)
ssbp2LisH domain-containing protein. (388 aa)
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Probably plays a role in the proliferation of vascular endothelial cells during blood vessel development. Establishes anterior identity at two levels; acts early to enhance canonical wnt-signaling by repressing expression of tle4, and acts later to inhibit nodal- signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a role in liver development. Induces heart development (By similarity). (274 aa)
ISL1ISL LIM homeobox 1. (349 aa)
glis1Uncharacterized protein. (330 aa)
isl2Uncharacterized protein. (353 aa)
znf710Solute carrier family 3 (amino acid transporter heavy chain), member 2. (700 aa)
nhlh1Citrate lyase beta like. (128 aa)
LHX6LIM homeobox 6. (351 aa)
rax2Leucine rich repeat containing 17. (227 aa)
lmo4.1LIM domain transcription factor LMO4.2; Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity). (184 aa)
gabra3PHD finger protein 19. (159 aa)
ENSXETP00000052435LIM zinc-binding domain-containing protein. (85 aa)
ZNF521Zinc finger protein 521. (1312 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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