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lmo4.2 lmo4.2 dlx6 dlx6 SHOX SHOX LHX2 LHX2 lypla1-2 lypla1-2 irx5 irx5 dlx2 dlx2 otp otp ssbp4 ssbp4 nr4a2 nr4a2 LMX1A LMX1A shox2 shox2 lmx1b.2 lmx1b.2 ldb1 ldb1 irx1 irx1 irx2 irx2 onecut1.2 onecut1.2 dlx5 dlx5 TBX15 TBX15 lhx9 lhx9 ldb2 ldb2 ssbp2 ssbp2 ISL1 ISL1 isl2 isl2 nhlh1 nhlh1 LHX6 LHX6 lmo4.1 lmo4.1 gabra3 gabra3 ENSXETP00000052435 ENSXETP00000052435 ZNF521 ZNF521
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
lmo4.2LIM domain transcription factor LMO4.1; Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity). (237 aa)
dlx6Sedoheptulokinase. (260 aa)
SHOXShort stature homeobox. (334 aa)
LHX2LIM homeobox 2. (419 aa)
lypla1-2Lysophospholipase 1. (410 aa)
irx5Iroquois-class homeodomain protein irx-5; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development. Involved in craniofacial and gonadal development (By similarity). Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. (486 aa)
dlx2Distal-less homeobox 2. (285 aa)
otpCKLF-like MARVEL transmembrane domain containing 4. (318 aa)
ssbp4Ceramide-1-phosphate transfer protein. (408 aa)
nr4a2Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons; Belongs to the nuclear hormone receptor family. (612 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (380 aa)
shox2Cartilage acidic protein 1. (311 aa)
lmx1b.2Decapping mRNA 1B. (374 aa)
ldb1LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. Acts as a coactivator together with otx2 to stimulate lhx1/lim1-mediated activation of the gsc promoter in the Spemann organizer. Acts synergistically with lhx1/lim1 and ssbp in axis formation (By similarity). (411 aa)
irx1Iroquois-class homeodomain protein irx-1; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up- regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds [...] (467 aa)
irx2Iroquois-class homeodomain protein irx-2; Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up- regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Probably dispensable for pronephric kidney development. (479 aa)
onecut1.2One cut domain family member. (417 aa)
dlx5Nuclear factor of activated T cells 3. (298 aa)
TBX15T-box transcription factor 15. (601 aa)
lhx9mRNA decay activator protein ZFP36L2. (398 aa)
ldb2Claudin 8, gene 1. (397 aa)
ssbp2LisH domain-containing protein. (388 aa)
ISL1ISL LIM homeobox 1. (349 aa)
isl2Uncharacterized protein. (353 aa)
nhlh1Citrate lyase beta like. (128 aa)
LHX6LIM homeobox 6. (351 aa)
lmo4.1LIM domain transcription factor LMO4.2; Acts as a positive cofactor of GATA transcription factors to establish the identity of the ventral mesoderm during gastrulation. Down-regulation in the dorsal mesoderm is necessary for the proper formation of this territory since, when present, lmo4 may bind ldb1 and restrict the availability of this cofactor for Spemman organizer transcription factors. At neurula stages, suppresses primary neuron differentiation and modulates gene expression at the Isthmic Organizer of the midbrain-hindbrain boundary (By similarity). (184 aa)
gabra3PHD finger protein 19. (159 aa)
ENSXETP00000052435LIM zinc-binding domain-containing protein. (85 aa)
ZNF521Zinc finger protein 521. (1312 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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