STRINGSTRING
entpd5 entpd5 nme3 nme3 nme2 nme2 nt5c1a nt5c1a Uckl1 Uckl1 impdh1 impdh1 GMPS GMPS guk1 guk1 entpd2 entpd2 ctps2 ctps2 cmpk1 cmpk1 ak5 ak5 adsl adsl nt5c3a nt5c3a rrm2b rrm2b ctps1 ctps1 adssl1 adssl1 ampd3 ampd3 hexb-2 hexb-2 pde7b pde7b entpd3 entpd3 hddc3 hddc3 ak2 ak2 ak1 ak1 AMPD1 AMPD1 ENTPD6 ENTPD6 aprt aprt cant1 cant1 entpd8 entpd8 ampd2 ampd2 ITPA ITPA gmpr2 gmpr2 nme6 nme6 entpd1 entpd1 nudt16 nudt16 PDE1C PDE1C rrm2.2 rrm2.2 rrm2.1 rrm2.1 impdh2 impdh2 ak6 ak6 rrm1 rrm1 AK4 AK4 pde1a pde1a atic atic ak7 ak7 adss adss entpd4 entpd4 gmpr gmpr pde11a pde11a adk adk PDE7A PDE7A ak3 ak3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
entpd5Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (428 aa)
nme3SRY-box 8; Belongs to the NDK family. (188 aa)
nme2Nucleoside diphosphate kinase. (204 aa)
nt5c1aUncharacterized protein. (430 aa)
Uckl1Uncharacterized protein. (176 aa)
impdh1Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (596 aa)
GMPSGuanine monophosphate synthase. (763 aa)
guk1EF-hand calcium-binding domain 7. (233 aa)
entpd2Mitogen-activated protein kinase 8 interacting protein 2; Belongs to the GDA1/CD39 NTPase family. (484 aa)
ctps2CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (599 aa)
cmpk1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (219 aa)
ak5Uncharacterized protein; Belongs to the adenylate kinase family. (557 aa)
adslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (513 aa)
nt5c3a5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (334 aa)
rrm2bUncharacterized protein. (416 aa)
ctps1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (602 aa)
adssl1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. (468 aa)
ampd3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa)
hexb-2Hexosaminidase B (beta polypeptide). (176 aa)
pde7bPhosphodiesterase. (506 aa)
entpd3Progesterone receptor membrane component 1; Belongs to the GDA1/CD39 NTPase family. (510 aa)
hddc3Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response. (179 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (235 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (502 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (771 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (469 aa)
aprtAdenine phosphoribosyltransferase. (180 aa)
cant1Calcium activated nucleotidase 1. (400 aa)
entpd8Forkhead box protein C2; Belongs to the GDA1/CD39 NTPase family. (478 aa)
ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (831 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (194 aa)
gmpr2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (381 aa)
nme6Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (179 aa)
entpd1NEDD4 binding protein 2-like 1; Belongs to the GDA1/CD39 NTPase family. (536 aa)
nudt16Solute carrier family 45 member 2. (213 aa)
PDE1CPhosphodiesterase. (710 aa)
rrm2.2Collagen, type VI, alpha 6. (447 aa)
rrm2.1Uncharacterized protein. (397 aa)
impdh2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (594 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (171 aa)
rrm1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (786 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (231 aa)
pde1aPhosphodiesterase. (541 aa)
aticMGS domain-containing protein. (607 aa)
ak7Adenylate kinase 7. (710 aa)
adssAdenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (477 aa)
entpd4Novel protein similar to cornifelin; Belongs to the GDA1/CD39 NTPase family. (621 aa)
gmprGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (363 aa)
pde11aUncharacterized protein. (892 aa)
adkTransmembrane phosphoinositide 3-phosphatase and tensin homolog 2. (370 aa)
PDE7APhosphodiesterase. (467 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (221 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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