(55 nodes) Nicotinate and nicotinamide metabolism, and NUDIX domain network (Xenopus tropicalis)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	sirt7	Deacetylase sirtuin-type domain-containing protein. (408 aa)
	LOC100485680	Chromosome 3 open reading frame 49. (260 aa)
	LOC100127789	Prolyl 4-hydroxylase, alpha polypeptide 1. (266 aa)
	LOC548368	Uncharacterized protein. (248 aa)
	nadk	Uncharacterized protein. (448 aa)
	nudt1	Leucine rich repeat and fibronectin type III domain containing 3; Belongs to the Nudix hydrolase family. (156 aa)
	nudt18	Protein phosphatase 1 regulatory subunit 3B. (329 aa)
	nkrf-2	NFKB repressing factor. (97 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (322 aa)
	nmnat2	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate (By similarity). Belongs to the eukaryotic NMN adenylyltransferase family. (307 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (358 aa)
	LOC100127826	Thromboxane A synthase 1. (261 aa)
	nadk2	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity). (427 aa)
	nnt	LRAT domain containing 1. (1086 aa)
	isoc1	Isochorismatase domain-containing protein 1; Belongs to the isochorismatase family. (310 aa)
	sirt6	Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
	LOC100145174	LOC100145174 protein. (260 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (309 aa)
	nudt5	Nudix (Nucleoside diphosphate linked moiety x) type motif 5; Belongs to the Nudix hydrolase family. (221 aa)
	LOC100496844	Glyoxylate reductase/hydroxypyruvate reductase, gene 2. (261 aa)
	LOC594886	Uncharacterized protein. (266 aa)
	LOC100496871	Uncharacterized protein. (266 aa)
	LOC100491286	Uncharacterized protein. (259 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (414 aa)
	sirt3.2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (401 aa)
	nadsyn1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (733 aa)
	nmrk1	Uncharacterized protein. (198 aa)
	LOC101733556	Sorcin. (303 aa)
	cd38	Fc receptor, IgG, high affinity I. (300 aa)
	nt5m	Potassium channel, voltage gated shaker related subfamily A, member 1. (227 aa)
	naprt	Zinc finger protein 33A. (216 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (302 aa)
	LOC100492724	Pim-3 proto-oncogene, serine/threonine kinase. (261 aa)
	MGC88898	Uncharacterized protein. (261 aa)
	LOC100492223	Solute carrier family 35 member F2. (261 aa)
	c11orf65-2	Chromosome 11 open reading frame 65. (143 aa)
	LOC100497323	Probable sodium-coupled neutral amino acid transporter 6. (261 aa)
	LOC100497161	Uncharacterized protein. (261 aa)
	LOC101733847	Obscurin-like 1. (261 aa)
	LOC100485981	Uncharacterized loc548369. (261 aa)
	prps1	Pribosyltran_N domain-containing protein. (322 aa)
	nmnat1	Nicotinamide-nucleotide adenylyltransferase. (320 aa)
	hlcs	Engrailed homeobox 2. (853 aa)
	nudt4	Nudix (Nucleoside diphosphate linked moiety X)-type motif 4. (180 aa)
	prps2	Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. (318 aa)
	NUDT15	Nudix hydrolase 15. (224 aa)
	nudt12	Paired like homeobox 2B. (458 aa)
	nampt	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (506 aa)
	adprm.2	Potassium channel tetramerization domain containing 7. (337 aa)
	adprm	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. (348 aa)
	sirt1	Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
	btd	FA complementation group C. (507 aa)
	LOC100490887	GPN-loop GTPase 3. (1066 aa)
	nmrk2	Uncharacterized protein. (233 aa)
	nrf1	Ribosomal RNA-processing 8. (556 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100127789	LOC101733556	ENSXETP00000002054	ENSXETP00000027854	Prolyl 4-hydroxylase, alpha polypeptide 1.	Sorcin.	0.650
LOC100127789	SIRT2	ENSXETP00000002054	ENSXETP00000024917	Prolyl 4-hydroxylase, alpha polypeptide 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.650
LOC100127789	SIRT3	ENSXETP00000002054	ENSXETP00000012303	Prolyl 4-hydroxylase, alpha polypeptide 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.650
LOC100127789	cd38	ENSXETP00000002054	ENSXETP00000027893	Prolyl 4-hydroxylase, alpha polypeptide 1.	Fc receptor, IgG, high affinity I.	0.650
LOC100127789	nampt	ENSXETP00000002054	ENSXETP00000046643	Prolyl 4-hydroxylase, alpha polypeptide 1.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.905
LOC100127789	sirt3.2	ENSXETP00000002054	ENSXETP00000025876	Prolyl 4-hydroxylase, alpha polypeptide 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.650
LOC100127789	sirt4	ENSXETP00000002054	ENSXETP00000008529	Prolyl 4-hydroxylase, alpha polypeptide 1.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.650
LOC100127789	sirt5	ENSXETP00000002054	ENSXETP00000020607	Prolyl 4-hydroxylase, alpha polypeptide 1.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.650
LOC100127789	sirt6	ENSXETP00000002054	ENSXETP00000018568	Prolyl 4-hydroxylase, alpha polypeptide 1.	Sirtuin (Silent mating type information regulation 2 homolog) 6.	0.650
LOC100127789	sirt7	ENSXETP00000002054	ENSXETP00000001649	Prolyl 4-hydroxylase, alpha polypeptide 1.	Deacetylase sirtuin-type domain-containing protein.	0.650
LOC100127826	LOC101733556	ENSXETP00000012357	ENSXETP00000027854	Thromboxane A synthase 1.	Sorcin.	0.650
LOC100127826	SIRT2	ENSXETP00000012357	ENSXETP00000024917	Thromboxane A synthase 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.650
LOC100127826	SIRT3	ENSXETP00000012357	ENSXETP00000012303	Thromboxane A synthase 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.650
LOC100127826	cd38	ENSXETP00000012357	ENSXETP00000027893	Thromboxane A synthase 1.	Fc receptor, IgG, high affinity I.	0.650
LOC100127826	nampt	ENSXETP00000012357	ENSXETP00000046643	Thromboxane A synthase 1.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.904
LOC100127826	sirt3.2	ENSXETP00000012357	ENSXETP00000025876	Thromboxane A synthase 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.650
LOC100127826	sirt4	ENSXETP00000012357	ENSXETP00000008529	Thromboxane A synthase 1.	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily.	0.650
LOC100127826	sirt5	ENSXETP00000012357	ENSXETP00000020607	Thromboxane A synthase 1.	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.650
LOC100127826	sirt6	ENSXETP00000012357	ENSXETP00000018568	Thromboxane A synthase 1.	Sirtuin (Silent mating type information regulation 2 homolog) 6.	0.650
LOC100127826	sirt7	ENSXETP00000012357	ENSXETP00000001649	Thromboxane A synthase 1.	Deacetylase sirtuin-type domain-containing protein.	0.650

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