(21 nodes) Mixed, incl. Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, and mRNA 3-UTR AU-rich region binding network (Xenopus tropicalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	cirbp	Cold-inducible RNA-binding protein; Cold-inducible mRNA binding protein. Acts cooperatively with elavl1/elrA to stabilize AU-rich element (ARE)-containing mRNAs by binding to themm and inhibiting their deadenylation. Essential for embryonic gastrulation and neural development, acting to maintain the expression of a set of adhesion molecules, and cell movement during embryogenesis. Required for pronephros development (By similarity). (198 aa)
	hnrnpa2b1	Uncharacterized protein. (355 aa)
	hnrnpa1	Pleckstrin and Sec7 domain containing 3. (362 aa)
	pick1	Uncharacterized protein. (435 aa)
	elavl1	ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs. May play a role during gastrulation. Required for the vegetal localization of vg1 mRNA (By similarity). (336 aa)
	rbmx	RRM domain-containing protein. (370 aa)
	SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein. (634 aa)
	hnrnph1	Uncharacterized protein. (485 aa)
	tardbp	TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity. (418 aa)
	ewsr1	Uncharacterized protein. (673 aa)
	ilf3	Interleukin enhancer-binding factor 3; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post- transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of tar [...] (1042 aa)
	fus	Uncharacterized protein. (547 aa)
	hnrnpdl	Heterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Binds DNA and RNA (By similarity). (319 aa)
	hnrnpu	Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A). (790 aa)
	hnrnph3	Cell division cycle 37. (428 aa)
	dhx9	U4/U6 small nuclear ribonucleoprotein Prp31. (1257 aa)
	matr3	Transcription factor 3. (892 aa)
	HNRNPM	Heterogeneous nuclear ribonucleoprotein M. (729 aa)
	hnrnpk	Heterogeneous nuclear ribonucleoprotein K. (399 aa)
	hnrnpa3	Deuterosome assembly protein 1. (383 aa)
	khdrbs1	Phosducin. (377 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HNRNPM	SYNCRIP	ENSXETP00000045339	ENSXETP00000007924	Heterogeneous nuclear ribonucleoprotein M.	Synaptotagmin binding cytoplasmic RNA interacting protein.	0.552
HNRNPM	dhx9	ENSXETP00000045339	ENSXETP00000032394	Heterogeneous nuclear ribonucleoprotein M.	U4/U6 small nuclear ribonucleoprotein Prp31.	0.757
HNRNPM	elavl1	ENSXETP00000045339	ENSXETP00000006138	Heterogeneous nuclear ribonucleoprotein M.	ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs. May play a role during gastrulation. Required for the vegetal localization of vg1 mRNA (By similarity).	0.608
HNRNPM	ewsr1	ENSXETP00000045339	ENSXETP00000026177	Heterogeneous nuclear ribonucleoprotein M.	Uncharacterized protein.	0.854
HNRNPM	fus	ENSXETP00000045339	ENSXETP00000027885	Heterogeneous nuclear ribonucleoprotein M.	Uncharacterized protein.	0.494
HNRNPM	hnrnpa1	ENSXETP00000045339	ENSXETP00000003807	Heterogeneous nuclear ribonucleoprotein M.	Pleckstrin and Sec7 domain containing 3.	0.955
HNRNPM	hnrnpa2b1	ENSXETP00000045339	ENSXETP00000002846	Heterogeneous nuclear ribonucleoprotein M.	Uncharacterized protein.	0.858
HNRNPM	hnrnpa3	ENSXETP00000045339	ENSXETP00000051099	Heterogeneous nuclear ribonucleoprotein M.	Deuterosome assembly protein 1.	0.955
HNRNPM	hnrnpdl	ENSXETP00000045339	ENSXETP00000028487	Heterogeneous nuclear ribonucleoprotein M.	Heterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Binds DNA and RNA (By similarity).	0.693
HNRNPM	hnrnph1	ENSXETP00000045339	ENSXETP00000008764	Heterogeneous nuclear ribonucleoprotein M.	Uncharacterized protein.	0.657
HNRNPM	hnrnph3	ENSXETP00000045339	ENSXETP00000031531	Heterogeneous nuclear ribonucleoprotein M.	Cell division cycle 37.	0.726
HNRNPM	hnrnpk	ENSXETP00000045339	ENSXETP00000047061	Heterogeneous nuclear ribonucleoprotein M.	Heterogeneous nuclear ribonucleoprotein K.	0.984
HNRNPM	hnrnpu	ENSXETP00000045339	ENSXETP00000030903	Heterogeneous nuclear ribonucleoprotein M.	Heterogeneous nuclear ribonucleoprotein U (Scaffold attachment factor A).	0.956
HNRNPM	ilf3	ENSXETP00000045339	ENSXETP00000026522	Heterogeneous nuclear ribonucleoprotein M.	Interleukin enhancer-binding factor 3; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post- transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of tar [...]	0.768
HNRNPM	khdrbs1	ENSXETP00000045339	ENSXETP00000053615	Heterogeneous nuclear ribonucleoprotein M.	Phosducin.	0.694
HNRNPM	matr3	ENSXETP00000045339	ENSXETP00000036311	Heterogeneous nuclear ribonucleoprotein M.	Transcription factor 3.	0.594
HNRNPM	rbmx	ENSXETP00000045339	ENSXETP00000007286	Heterogeneous nuclear ribonucleoprotein M.	RRM domain-containing protein.	0.948
HNRNPM	tardbp	ENSXETP00000045339	ENSXETP00000011689	Heterogeneous nuclear ribonucleoprotein M.	TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity.	0.727
SYNCRIP	HNRNPM	ENSXETP00000007924	ENSXETP00000045339	Synaptotagmin binding cytoplasmic RNA interacting protein.	Heterogeneous nuclear ribonucleoprotein M.	0.552
SYNCRIP	dhx9	ENSXETP00000007924	ENSXETP00000032394	Synaptotagmin binding cytoplasmic RNA interacting protein.	U4/U6 small nuclear ribonucleoprotein Prp31.	0.469

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