(21 nodes) Notch signaling pathway network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	dtx1	Rhomboid domain containing 2. (623 aa)
	aqp11-2	Aquaporin 11. (994 aa)
	rbpj	Ubiquinol-cytochrome c reductase core protein 2. (464 aa)
	LOC101731574	Bromo domain-containing protein. (84 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1133 aa)
	notch2	FTO alpha-ketoglutarate dependent dioxygenase. (2455 aa)
	dtx3	Dtx3 protein. (353 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	dlc	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (642 aa)
	rfng	Beta-1,3-N-acetylglucosaminyltransferase. (364 aa)
	lfng	Beta-1,3-N-acetylglucosaminyltransferase. (372 aa)
	dtx2	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (592 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (740 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1088 aa)
	maml1	Protein phosphatase methylesterase 1. (1030 aa)
	notch4	Uncharacterized protein. (1581 aa)
	Notch4	ANK_REP_REGION domain-containing protein. (168 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa)
	notch1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2535 aa)
	NOTCH3	Notch receptor 3. (2413 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL4	MAML3	ENSXETP00000053783	ENSXETP00000037334	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.429
DLL4	NOTCH3	ENSXETP00000053783	ENSXETP00000053473	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.971
DLL4	Notch4	ENSXETP00000053783	ENSXETP00000048065	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ANK_REP_REGION domain-containing protein.	0.959
DLL4	aqp11-2	ENSXETP00000053783	ENSXETP00000010545	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Aquaporin 11.	0.477
DLL4	dlc	ENSXETP00000053783	ENSXETP00000023384	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.910
DLL4	dll1	ENSXETP00000053783	ENSXETP00000029635	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.907
DLL4	maml1	ENSXETP00000053783	ENSXETP00000038109	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Protein phosphatase methylesterase 1.	0.429
DLL4	notch1	ENSXETP00000053783	ENSXETP00000053343	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.989
DLL4	notch2	ENSXETP00000053783	ENSXETP00000015957	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	FTO alpha-ketoglutarate dependent dioxygenase.	0.974
DLL4	notch4	ENSXETP00000053783	ENSXETP00000048059	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.845
DLL4	rbpj	ENSXETP00000053783	ENSXETP00000010625	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Ubiquinol-cytochrome c reductase core protein 2.	0.687
JAG2	MAML3	ENSXETP00000015408	ENSXETP00000037334	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 3.	0.509
JAG2	NOTCH3	ENSXETP00000015408	ENSXETP00000053473	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.775
JAG2	Notch4	ENSXETP00000015408	ENSXETP00000048065	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ANK_REP_REGION domain-containing protein.	0.599
JAG2	aqp11-2	ENSXETP00000015408	ENSXETP00000010545	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Aquaporin 11.	0.550
JAG2	maml1	ENSXETP00000015408	ENSXETP00000038109	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Protein phosphatase methylesterase 1.	0.527
JAG2	notch1	ENSXETP00000015408	ENSXETP00000053343	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.911
JAG2	notch2	ENSXETP00000015408	ENSXETP00000015957	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	FTO alpha-ketoglutarate dependent dioxygenase.	0.780
JAG2	notch4	ENSXETP00000015408	ENSXETP00000048059	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.807
JAG2	rbpj	ENSXETP00000015408	ENSXETP00000010625	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Ubiquinol-cytochrome c reductase core protein 2.	0.677

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