(52 nodes) Mixed, incl. Regulation of plasma lipoprotein particle levels, and Purine nucleobase metabolic process network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	abcg5	LOC100145776 protein. (653 aa)
	hoxa13-2	Uncharacterized protein. (213 aa)
	ADAMTS20	ADAM metallopeptidase with thrombospondin type 1 motif 20. (1866 aa)
	acot9	Uncharacterized protein. (435 aa)
	urah	5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (143 aa)
	per3-2	Period circadian regulator 3. (87 aa)
	rasd1	Uncharacterized protein. (283 aa)
	abcg1	Glutamate receptor, ionotropic, kainate 1. (672 aa)
	LOC100135198	Uncharacterized protein. (228 aa)
	apoa4	Uncharacterized protein. (407 aa)
	urad	Vascular endothelial growth factor A. (175 aa)
	ccdc93-2	Coiled-coil domain-containing protein 93. (485 aa)
	Apoc2	Uncharacterized protein. (56 aa)
	abcg8	WD repeat domain 33. (666 aa)
	rbp4l	Retinol-binding protein 4,-like; Belongs to the calycin superfamily. Lipocalin family. (196 aa)
	mttp.1	Solute carrier family 39 (zinc transporter), member 2. (931 aa)
	allc	Allantoicase; Utilization of purines as secondary nitrogen sources, when primary sources are limiting. (389 aa)
	MYADML2	Myeloid associated differentiation marker like 2. (302 aa)
	Lmf1	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (370 aa)
	apob	Probable ATP-dependent RNA helicase ddx6. (4594 aa)
	uox	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (304 aa)
	mttp.2	Vitellogenin domain-containing protein. (881 aa)
	syap1	Synapse associated protein 1, SAP47 homolog. (364 aa)
	rbp1	Target of EGR1, exonuclease; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (136 aa)
	fabp2	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	ccn3	Superoxide dismutase [Cu-Zn]. (344 aa)
	pltp	Uncharacterized protein. (498 aa)
	adamts12	ADAM metallopeptidase domain 10. (1540 aa)
	adamts1	Nudix hydrolase 1. (979 aa)
	apoa1	Uncharacterized protein. (273 aa)
	apoa5	Uncharacterized protein. (343 aa)
	ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif 7. (1561 aa)
	PDZK1IP1	PDZK1 interacting protein 1. (113 aa)
	apoc1	Eukaryotic translation initiation factor 4A3. (85 aa)
	apoe	Apoe protein. (275 aa)
	STRA6	Stimulated by retinoic acid 6. (637 aa)
	fabp1	DEAH-box helicase 9. (153 aa)
	angptl3	Carboxylesterase 3, gene 1. (456 aa)
	xpr1	Xenotropic and polytropic retrovirus receptor 1 homolog; Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules. (692 aa)
	LRRC18	Leucine rich repeat containing 18. (257 aa)
	scarf1	Tumor protein p53 binding protein 2. (890 aa)
	rbp4	MGC107934 protein; Belongs to the calycin superfamily. Lipocalin family. (199 aa)
	scarb2	Uncharacterized protein; Belongs to the CD36 family. (487 aa)
	LOC100498039	Protoporphyrinogen oxidase. (496 aa)
	nr1h4	Protein phosphatase 5, catalytic subunit. (458 aa)
	cyp27a1	Uncharacterized protein; Belongs to the cytochrome P450 family. (537 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa)
	ENSXETP00000052124	Uncharacterized protein; Belongs to the CD36 family. (400 aa)
	INO80D	INO80 complex subunit D. (1024 aa)
	ttr	Transthyretin; Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain (By similarity); Belongs to the transthyretin family. (151 aa)
	LOC100496911	FBJ murine osteosarcoma viral oncogene homolog B. (3428 aa)
	apof	Velo1 protein. (311 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS7	INO80D	ENSXETP00000035067	ENSXETP00000052819	ADAM metallopeptidase with thrombospondin type 1 motif 7.	INO80 complex subunit D.	0.454
Apoc2	apob	ENSXETP00000012949	ENSXETP00000024642	Uncharacterized protein.	Probable ATP-dependent RNA helicase ddx6.	0.425
Apoc2	apoc1	ENSXETP00000012949	ENSXETP00000036113	Uncharacterized protein.	Eukaryotic translation initiation factor 4A3.	0.543
Apoc2	apoe	ENSXETP00000012949	ENSXETP00000036125	Uncharacterized protein.	Apoe protein.	0.895
CETP	LOC100496911	ENSXETP00000050678	ENSXETP00000053542	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	FBJ murine osteosarcoma viral oncogene homolog B.	0.498
CETP	abcg1	ENSXETP00000050678	ENSXETP00000008430	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Glutamate receptor, ionotropic, kainate 1.	0.425
CETP	apoa5	ENSXETP00000050678	ENSXETP00000033062	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Uncharacterized protein.	0.559
CETP	apob	ENSXETP00000050678	ENSXETP00000024642	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Probable ATP-dependent RNA helicase ddx6.	0.651
CETP	apoe	ENSXETP00000050678	ENSXETP00000036125	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Apoe protein.	0.577
CETP	apof	ENSXETP00000050678	ENSXETP00000053891	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Velo1 protein.	0.590
ENSXETP00000052124	apob	ENSXETP00000052124	ENSXETP00000024642	Uncharacterized protein; Belongs to the CD36 family.	Probable ATP-dependent RNA helicase ddx6.	0.477
INO80D	ADAMTS7	ENSXETP00000052819	ENSXETP00000035067	INO80 complex subunit D.	ADAM metallopeptidase with thrombospondin type 1 motif 7.	0.454
INO80D	adamts12	ENSXETP00000052819	ENSXETP00000032180	INO80 complex subunit D.	ADAM metallopeptidase domain 10.	0.454
INO80D	ttr	ENSXETP00000052819	ENSXETP00000053118	INO80 complex subunit D.	Transthyretin; Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain (By similarity); Belongs to the transthyretin family.	0.600
LOC100135198	apoa1	ENSXETP00000010857	ENSXETP00000033026	Uncharacterized protein.	Uncharacterized protein.	0.908
LOC100496911	CETP	ENSXETP00000053542	ENSXETP00000050678	FBJ murine osteosarcoma viral oncogene homolog B.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.498
LOC100496911	angptl3	ENSXETP00000053542	ENSXETP00000041541	FBJ murine osteosarcoma viral oncogene homolog B.	Carboxylesterase 3, gene 1.	0.485
LOC100496911	apoa1	ENSXETP00000053542	ENSXETP00000033026	FBJ murine osteosarcoma viral oncogene homolog B.	Uncharacterized protein.	0.501
LOC100496911	apoa4	ENSXETP00000053542	ENSXETP00000010880	FBJ murine osteosarcoma viral oncogene homolog B.	Uncharacterized protein.	0.528
LOC100496911	apoa5	ENSXETP00000053542	ENSXETP00000033062	FBJ murine osteosarcoma viral oncogene homolog B.	Uncharacterized protein.	0.454

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