(28 nodes) Mixed, incl. ADAM cysteine-rich, and PHR domain network (Xenopus tropicalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hesx1	Homeobox expressed in ES cells 1; Regulates the earliest stages of development of the anterior neural plate. Plays a role in forebrain development by inhibiting the expression of otx2 and pax6 in the rostral region of the anterior neural plate. Necessary for both neural differentiation and neural patterning. Controls Spemann organizer development. May act as a transcriptional repressor (By similarity). (186 aa)
	LOC101732154	Fatty acid desaturase 6. (261 aa)
	VAX1	Ventral anterior homeobox 1. (149 aa)
	btbd2	Kelch domain containing 7A. (545 aa)
	btbd3	LOC100036676 protein. (518 aa)
	nsun2-2	RNA cytosine-C(5)-methyltransferase NSUN2. (63 aa)
	tasp1	Uncharacterized protein. (444 aa)
	irf6	Novel protein similar to interferon regulatory factor transcription factor. (460 aa)
	irf6.2	Novel protein similar to interferon regulatory factor transcription factor. (460 aa)
	nipsnap3a	Uncharacterized protein. (256 aa)
	BRAP	BRCA1 associated protein. (585 aa)
	twsg2	Twisted gastrulation homolog 2. (244 aa)
	PURB	Purine rich element binding protein B. (311 aa)
	sash1	Amyloid beta precursor protein (cytoplasmic tail) binding protein 2. (1003 aa)
	tmem248	Transmembrane protein 248. (346 aa)
	ism2	AMOP domain-containing protein. (455 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1248 aa)
	mkx	Tetraspanin 17. (350 aa)
	LOC548655	Uncharacterized protein. (356 aa)
	itln1	Fibrinogen C-terminal domain-containing protein. (342 aa)
	mchr1.1-2	Disintegrin domain-containing protein. (126 aa)
	dleu7-2	Secretory carrier membrane protein 3. (143 aa)
	cabp4-3	Calcium binding protein 4. (114 aa)
	slc35g2-2	Fukutin related protein. (112 aa)
	vim	IF rod domain-containing protein; Belongs to the intermediate filament family. (467 aa)
	fam49b	Uncharacterized protein. (374 aa)
	btbd1	BTB domain-containing protein. (502 aa)
	irf5	IRF tryptophan pentad repeat domain-containing protein. (514 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101732154	irf6.2	ENSXETP00000008618	ENSXETP00000029641	Fatty acid desaturase 6.	Novel protein similar to interferon regulatory factor transcription factor.	0.671
PURB	tmem248	ENSXETP00000036253	ENSXETP00000037694	Purine rich element binding protein B.	Transmembrane protein 248.	0.535
btbd3	ism2	ENSXETP00000017583	ENSXETP00000038612	LOC100036676 protein.	AMOP domain-containing protein.	0.593
btbd3	tasp1	ENSXETP00000017583	ENSXETP00000025480	LOC100036676 protein.	Uncharacterized protein.	0.602
fam49b	tasp1	ENSXETP00000053896	ENSXETP00000025480	Uncharacterized protein.	Uncharacterized protein.	0.601
irf6.2	LOC101732154	ENSXETP00000029641	ENSXETP00000008618	Novel protein similar to interferon regulatory factor transcription factor.	Fatty acid desaturase 6.	0.671
irf6.2	itln1	ENSXETP00000029641	ENSXETP00000046810	Novel protein similar to interferon regulatory factor transcription factor.	Fibrinogen C-terminal domain-containing protein.	0.459
ism2	btbd3	ENSXETP00000038612	ENSXETP00000017583	AMOP domain-containing protein.	LOC100036676 protein.	0.593
ism2	tasp1	ENSXETP00000038612	ENSXETP00000025480	AMOP domain-containing protein.	Uncharacterized protein.	0.572
itln1	irf6.2	ENSXETP00000046810	ENSXETP00000029641	Fibrinogen C-terminal domain-containing protein.	Novel protein similar to interferon regulatory factor transcription factor.	0.459
itln1	vim	ENSXETP00000046810	ENSXETP00000052534	Fibrinogen C-terminal domain-containing protein.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.459
mkx	tmem248	ENSXETP00000044918	ENSXETP00000037694	Tetraspanin 17.	Transmembrane protein 248.	0.421
tasp1	btbd3	ENSXETP00000025480	ENSXETP00000017583	Uncharacterized protein.	LOC100036676 protein.	0.602
tasp1	fam49b	ENSXETP00000025480	ENSXETP00000053896	Uncharacterized protein.	Uncharacterized protein.	0.601
tasp1	ism2	ENSXETP00000025480	ENSXETP00000038612	Uncharacterized protein.	AMOP domain-containing protein.	0.572
tmem248	PURB	ENSXETP00000037694	ENSXETP00000036253	Transmembrane protein 248.	Purine rich element binding protein B.	0.535
tmem248	mkx	ENSXETP00000037694	ENSXETP00000044918	Transmembrane protein 248.	Tetraspanin 17.	0.421
vim	itln1	ENSXETP00000052534	ENSXETP00000046810	IF rod domain-containing protein; Belongs to the intermediate filament family.	Fibrinogen C-terminal domain-containing protein.	0.459

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