(57 nodes) One carbon pool by folate, and Glycine, serine and threonine metabolism network (Xenopus tropicalis)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	sds	DEAH-box helicase 15. (328 aa)
	sdsl	PALP domain-containing protein. (332 aa)
	mat1a	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
	SARDH	Sarcosine dehydrogenase. (906 aa)
	dhfr	DHFR domain-containing protein. (204 aa)
	ENSXETP00000005678	Membrane associated ring-CH-type finger 9. (250 aa)
	pld1-2	Phospholipase D1. (919 aa)
	fpgs	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (589 aa)
	alas2	5-aminolevulinate synthase. (608 aa)
	bhmt	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). (438 aa)
	gcsh	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (170 aa)
	mthfd1	Uncharacterized protein. (952 aa)
	mthfd2	Uncharacterized protein. (336 aa)
	LOC100490060	CD274 molecule. (498 aa)
	psph	Uncharacterized protein. (251 aa)
	MGC75760	Hcy-binding domain-containing protein. (311 aa)
	aldh1l2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (922 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
	dnmt3a	Inositol monophosphatase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (952 aa)
	shmt2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (514 aa)
	MTFMT	Mitochondrial methionyl-tRNA formyltransferase. (492 aa)
	LOC101730350	Peroxiredoxin 2. (425 aa)
	mthfd1l	Calmodulin-like protein 4. (958 aa)
	LOC100497030	NIPA-like domain containing 3. (541 aa)
	tha1p	Beta_elim_lyase domain-containing protein. (409 aa)
	PDPR	Pyruvate dehydrogenase phosphatase regulatory subunit. (895 aa)
	ppat	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
	paics.1	AIRC domain-containing protein. (490 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (485 aa)
	mat2b	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). (334 aa)
	aldh1l1	Cytosolic 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (951 aa)
	mthfd2l	Pancreatic progenitor cell differentiation and proliferation factor. (353 aa)
	phgdh	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (509 aa)
	dmgdh	STIL, centriolar assembly protein. (874 aa)
	ahcyl1	Acyl-CoA thioesterase 8; Belongs to the adenosylhomocysteinase family. (574 aa)
	LOC100492187	PHD-type domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (472 aa)
	Gnmt	Uncharacterized protein. (69 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1492 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1016 aa)
	srr	LOC100144980 protein. (323 aa)
	mat2a	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
	thnsl2	Keratinocyte associated protein 3. (476 aa)
	dao	Telomeric repeat-binding factor 2-interacting protein 1. (368 aa)
	psat1	Transmembrane and coiled-coil domains 3. (392 aa)
	alas1	5-aminolevulinate synthase. (628 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (676 aa)
	gcat	Plakophilin 4. (428 aa)
	mthfs	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (204 aa)
	tyms	Cytochrome b-245, beta polypeptide. (308 aa)
	ftcd	Clock circadian regulator. (560 aa)
	dhfr-2	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (189 aa)
	ahcy	AdoHcyase_NAD domain-containing protein; Belongs to the adenosylhomocysteinase family. (435 aa)
	thnsl1	Solute carrier family 49 member 4 homolog. (783 aa)
	AMT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (409 aa)
	pipox	Ataxin 2. (393 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1024 aa)
	ahcyl2	AdoHcyase_NAD domain-containing protein; Belongs to the adenosylhomocysteinase family. (606 aa)

Your Current Organism:

Xenopus tropicalis

NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMT	ENSXETP00000005678	ENSXETP00000049638	ENSXETP00000005678	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Membrane associated ring-CH-type finger 9.	0.981
AMT	GLDC	ENSXETP00000049638	ENSXETP00000053173	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.999
AMT	LOC100490060	ENSXETP00000049638	ENSXETP00000014609	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	CD274 molecule.	0.609
AMT	MGC75760	ENSXETP00000049638	ENSXETP00000017642	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Hcy-binding domain-containing protein.	0.515
AMT	MTFMT	ENSXETP00000049638	ENSXETP00000022525	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Mitochondrial methionyl-tRNA formyltransferase.	0.938
AMT	aldh1l1	ENSXETP00000049638	ENSXETP00000028910	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Cytosolic 10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.934
AMT	aldh1l2	ENSXETP00000049638	ENSXETP00000017879	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.934
AMT	bhmt	ENSXETP00000049638	ENSXETP00000010562	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity).	0.515
AMT	dao	ENSXETP00000049638	ENSXETP00000038232	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Telomeric repeat-binding factor 2-interacting protein 1.	0.597
AMT	dhfr	ENSXETP00000049638	ENSXETP00000004883	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	DHFR domain-containing protein.	0.955
AMT	dhfr-2	ENSXETP00000049638	ENSXETP00000045637	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.955
AMT	fpgs	ENSXETP00000049638	ENSXETP00000007312	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.628
AMT	ftcd	ENSXETP00000049638	ENSXETP00000045271	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Clock circadian regulator.	0.936
AMT	gart	ENSXETP00000049638	ENSXETP00000035603	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.981
AMT	gcat	ENSXETP00000049638	ENSXETP00000042647	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Plakophilin 4.	0.665
AMT	gcsh	ENSXETP00000049638	ENSXETP00000013045	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.998
AMT	mat1a	ENSXETP00000049638	ENSXETP00000001311	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.468
AMT	mat2a	ENSXETP00000049638	ENSXETP00000036425	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.468
AMT	mthfd1	ENSXETP00000049638	ENSXETP00000013951	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.954
AMT	mthfd1l	ENSXETP00000049638	ENSXETP00000024459	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Calmodulin-like protein 4.	0.561

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