STRINGSTRING
slc35f6 slc35f6 supt5h supt5h paf1 paf1 supt4h1 supt4h1 polr3g polr3g Maf1 Maf1 polr3f polr3f SUPT6H SUPT6H LOC101732780 LOC101732780 polr2d-2 polr2d-2 polr2g polr2g polr3gl polr3gl brf1 brf1 polr3e polr3e polr2e polr2e polr1e polr1e ENSXETP00000019883 ENSXETP00000019883 polr2c polr2c ctdnep1 ctdnep1 crcp crcp polr3d polr3d polr3h polr3h ppp3cb-2 ppp3cb-2 POLR1C POLR1C polr3c polr3c polr3k polr3k polr2j polr2j ctr9 ctr9 ssrp1 ssrp1 polr3b polr3b plod1-2 plod1-2 polr2k polr2k eepd1 eepd1 fancg-2 fancg-2 ENSXETP00000031588 ENSXETP00000031588 polr2l.2 polr2l.2 ENSXETP00000034802 ENSXETP00000034802 mecp2-2 mecp2-2 POLR1B POLR1B cdc73 cdc73 POLR1A POLR1A polr2h polr2h tceanc tceanc tcea1 tcea1 cd3eap cd3eap elof1 elof1 srbd1 srbd1 polr2f polr2f iws1 iws1 polr1d.2 polr1d.2 polr2l.1 polr2l.1 brf2 brf2 bdp1 bdp1 polr2b polr2b polr2i polr2i twistnb twistnb cdk12 cdk12 ctdp1 ctdp1 CINP CINP polr3a polr3a ccnk ccnk LEO1 LEO1 RRN3 RRN3 rtf1 rtf1 ZNRD1 ZNRD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
slc35f6Solute carrier family 35 member F6. (236 aa)
supt5hTranscription elongation factor SPT5. (1078 aa)
paf1RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (520 aa)
supt4h1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
polr3gUncharacterized protein. (192 aa)
Maf1Uncharacterized protein. (114 aa)
polr3fDNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (317 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1728 aa)
LOC101732780Uncharacterized 51.9 kDa protein in rps4-rps11 intergenic region-like. (346 aa)
polr2d-2Polymerase (RNA) II (DNA directed) polypeptide D. (142 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G. (172 aa)
polr3glDNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (215 aa)
brf1Neuronal PAS domain protein 3. (711 aa)
polr3eUncharacterized protein. (701 aa)
polr2ePolymerase (RNA) II (DNA directed) polypeptide E. (210 aa)
polr1eUncharacterized protein. (420 aa)
ENSXETP00000019883Ankyrin repeat domain 13A. (129 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C, 33kDa. (275 aa)
ctdnep1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1638 aa)
crcpRPOL4c domain-containing protein. (146 aa)
polr3dPolymerase (RNA) III (DNA directed) polypeptide D, 44kDa. (394 aa)
polr3hMyeloid-associated differentiation marker-like 2. (227 aa)
ppp3cb-2Chromosome X open reading frame 22. (117 aa)
POLR1CRNA polymerase I and III subunit C. (365 aa)
polr3cNucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. (568 aa)
polr3kDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
polr2jTransmembrane protein 231. (126 aa)
ctr9RNA polymerase-associated protein CTR9 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II (By similarity). PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (1149 aa)
ssrp1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (698 aa)
polr3bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1142 aa)
plod1-2Uncharacterized protein. (226 aa)
polr2kUncharacterized protein. (68 aa)
eepd1Thyroid hormone down-regulated protein (gene 20). (556 aa)
fancg-2Solute carrier family 35 member F4. (1035 aa)
ENSXETP00000031588Family with sequence similarity 172 member A. (107 aa)
polr2l.2S-phase cyclin A-associated protein in the ER. (67 aa)
ENSXETP00000034802Uncharacterized protein. (139 aa)
mecp2-2Methyl-CpG binding protein 2. (313 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1141 aa)
cdc73Hyperparathyroidism 2 (With jaw tumor). (531 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1698 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
tceancLOC100145741 protein. (349 aa)
tcea1Uncharacterized protein. (305 aa)
cd3eapUncharacterized protein. (197 aa)
elof1Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (87 aa)
srbd1Coiled-coil domain-containing protein 69. (945 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
iws1Protein IWS1 homolog; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts; Belongs to the IWS1 family. (893 aa)
polr1d.2TIA1 cytotoxic granule-associated RNA binding protein-like 1. (128 aa)
polr2l.1Polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa. (67 aa)
brf2Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family. (519 aa)
bdp1SANT domain-containing protein. (2372 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
polr2iSolute carrier family 25 member 3. (133 aa)
twistnbFamily with sequence similarity 222 member B. (471 aa)
cdk12Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating srsf1/sf2 (By similarity). (1466 aa)
ctdp1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (994 aa)
CINPCyclin dependent kinase 2 interacting protein. (211 aa)
polr3aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
ccnkUncharacterized protein; Belongs to the cyclin family. (659 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (718 aa)
RRN3RRN3 homolog, RNA polymerase I transcription factor. (613 aa)
rtf1Plus3 domain-containing protein. (675 aa)
ZNRD1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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