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| | cenpu | Centromere protein N. (531 aa) |
| | KNTC1 | Kinetochore associated 1. (2236 aa) |
| | pax8-2 | Uncharacterized protein. (294 aa) |
| | mis18a | Meiosis/spermiogenesis associated 1. (207 aa) |
| | mad2l1bp | Poly(ADP-ribose) polymerase family member 6. (247 aa) |
| | cenpe | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (3296 aa) |
| | ndc80 | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa) |
| | bod1 | Biorientation of chromosomes in cell division protein 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Belongs to the BOD1 family. (169 aa) |
| | mis12 | Uncharacterized protein. (221 aa) |
| | kifbp | KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development; Belongs to the KIF-binding protein family. (616 aa) |
| | pclaf | PCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number (By similarity). (125 aa) |
| | nolc1-2 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (377 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1411 aa) |
| | mad2l1 | PIF1 5'-to-3' DNA helicase. (203 aa) |
| | dlgap5 | Uncharacterized protein. (913 aa) |
| | mad1l1 | Neutrophil cytosolic factor 4. (605 aa) |
| | ncapd3 | Pre-mRNA-splicing factor 38A. (1492 aa) |
| | aspm | LDL receptor related protein 8. (3347 aa) |
| | kif4a | Cytochrome P450 family 2 subfamily A member 6 gene 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1230 aa) |
| | nek2 | Matrix metallopeptidase 9. (444 aa) |
| | zwilch | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity). (597 aa) |
| | cenpo | Centromere protein O; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-O/MCM21 family. (330 aa) |
| | nsl1 | Uncharacterized protein. (880 aa) |
| | cenpm | Arachidonate 5-lipoxygenase. (199 aa) |
| | kif23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (970 aa) |
| | pbk | PDZ binding kinase. (325 aa) |
| | spdl1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity); Belongs to the Spindly family. (611 aa) |
| | c1orf112 | Ankyrin repeat domain 40. (839 aa) |
| | ncapg | Protein tyrosine phosphatase non-receptor type 9. (1041 aa) |
| | ska1 | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a [...] (256 aa) |
| | ncaph2 | Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. (624 aa) |
| | dsn1 | Uncharacterized protein. (340 aa) |
| | melk | Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis. Plays a role in cytokinesis during early development (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (639 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1368 aa) |
| | racgap1 | Uncharacterized protein. (632 aa) |
| | incenp | Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within [...] (924 aa) |
| | cdca3 | Arrestin domain containing 4. (307 aa) |
| | prc1.2 | Uncharacterized protein. (643 aa) |
| | smc2 | Structural maintenance of chromosomes protein. (1225 aa) |
| | cenpc | CENP-C_C domain-containing protein. (1378 aa) |
| | ccna1 | DEP domain containing 1B; Belongs to the cyclin family. (426 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (1901 aa) |
| | kif24 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (910 aa) |
| | ska3 | Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the p [...] (564 aa) |
| | pmf1 | LOC100037873 protein. (202 aa) |
| | ska2 | Phosphoinositide-3-kinase interacting protein 1. (163 aa) |
| | trip13 | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity). (453 aa) |
| | cenpt | Prostaglandin D2 synthase. (777 aa) |
| | kif18a | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (947 aa) |
| | BORA | BORA aurora kinase A activator. (601 aa) |
| | sertad1 | SERTA domain-containing protein. (247 aa) |
| | parpbp | PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability; Belongs to the PARI family. (573 aa) |
| | LOC100494653 | Histone deacetylase complex subunit SAP30L; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (981 aa) |
| | fam72a | Spermatogenesis associated 1. (151 aa) |
| | spc24 | Kinetochore protein spc24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (205 aa) |
| | bub1 | BUB1 budding uninhibited by benzimidazoles 1 homolog. (1122 aa) |
| | ANLN | Anillin actin binding protein. (1113 aa) |
| | ube2c | Myotubularin related protein 2; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | KIF18B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (872 aa) |
| | cenpi | Uncharacterized protein. (718 aa) |
| | CENPF | Centromere protein F. (2609 aa) |
| | ttk | Protein kinase domain-containing protein. (879 aa) |
| | cdca9 | Borealin-2; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes (By similarity). (296 aa) |
| | kif2c | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (715 aa) |
| | anln | PH domain-containing protein. (873 aa) |
| | CENPW | Centromere protein W. (108 aa) |
| | nuf2 | Msh homeobox 1. (462 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (415 aa) |
| | shcbp1 | Beta_helix domain-containing protein. (735 aa) |
| | kif11 | Kinesin-like protein KIF11; Plus end-directed motor protein required for establishing a bipolar spindle. Associates with both interphase and mitotic spindle microtubules. May be involved in nuclear divisions taking place during the development of unfertilized eggs. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. (1067 aa) |
| | LOC101732421 | Baculoviral IAP repeat-containing protein 5.1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity (By similarity). (139 aa) |
| | ENSXETP00000034866 | Transmembrane protein 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (304 aa) |
| | tpx2 | Targeting protein for Xklp2; Spindle assembly factor. Required for normal assembly of mitotic spindles. Mediates the binding kif15 and aurka to spindle microtubules. Required for targeting kif15 to microtubule minus ends. Activates aurka by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation (By similarity). Belongs to the TPX2 family. (502 aa) |
| | ncaph | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (704 aa) |
| | cenpn | Centromere protein N; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-N/CHL4 family. (366 aa) |
| | cdk1 | Cell division cycle 2, G1 to S and G2 to M; Belongs to the protein kinase superfamily. (302 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1305 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1152 aa) |
| | spag5 | Interferon induced, with helicase C domain 1. (1498 aa) |
| | cdc20b | VPS54 GARP complex subunit. (519 aa) |
| | bub3 | Uncharacterized protein. (342 aa) |
| | cdca2 | Gremlin 1, DAN family BMP antagonist. (1120 aa) |
| | LOC100498440 | Actinin alpha 4. (202 aa) |
| | ENSXETP00000040621 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (679 aa) |
| | svil | Coiled-coil domain containing 181. (2279 aa) |
| | prc1 | Uncharacterized protein. (615 aa) |
| | cenpl | Centromere protein L; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-L/IML3 family. (348 aa) |
| | ect2 | Survival of motor neuron 1. (987 aa) |
| | CENPK | Centromere protein K. (291 aa) |
| | aurkb | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (375 aa) |
| | foxm1 | AT-hook DNA binding motif containing 1. (754 aa) |
| | spc25 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. (228 aa) |
| | cep55 | 1-acylglycerol-3-phosphate O-acyltransferase 3. (375 aa) |
| | KIF15 | Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1384 aa) |
| | kif20b | Tripartite motif containing 28; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1864 aa) |
| | kif20a | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (910 aa) |
| | depdc1 | DEP domain-containing protein. (822 aa) |
| | plk2 | Uncharacterized protein. (788 aa) |
| | racgap1.2 | Bruton tyrosine kinase. (591 aa) |
| | scg5 | Myotilin. (1169 aa) |
| | ckap2l | Cytoskeleton associated protein 2 like. (774 aa) |
| | bub1b | Uncharacterized protein. (1022 aa) |
| | knl1 | Uncharacterized loc496670. (2794 aa) |
| | oip5 | Retina and anterior neural fold homeobox. (199 aa) |
| | nusap1 | Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of meiotic or mitotic spindle microtubules around them (By similarity). (569 aa) |
| | cdca8 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes (By similarity). (279 aa) |
