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| | MMS22L | MMS22 like, DNA repair protein. (1233 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (806 aa) |
| | FBH1 | F-box DNA helicase 1. (1034 aa) |
| | nsmce2 | Ring finger protein 34, E3 ubiquitin protein ligase. (203 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1012 aa) |
| | INO80 | INO80 complex ATPase subunit. (1547 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (336 aa) |
| | RMI2 | RecQ mediated genome instability 2. (155 aa) |
| | psmd14 | Prokineticin receptor 2. (313 aa) |
| | cdc7 | AT-rich interaction domain 1A. (557 aa) |
| | rad54l | Uncharacterized protein. (773 aa) |
| | slc9a1-2 | Solute carrier family 9 member 1. (465 aa) |
| | mcm7 | DNA replication licensing factor mcm7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (723 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (678 aa) |
| | rad52 | Phospholipase D2. (444 aa) |
| | rbbp8 | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. (856 aa) |
| | mcm6.2 | Zygotic DNA replication licensing factor mcm6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute diff [...] (837 aa) |
| | recql5 | Uncharacterized protein. (1035 aa) |
| | rmi1 | DUF1767 domain-containing protein. (509 aa) |
| | nsmce1 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. Belongs to the NSE1 family. (270 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | swsap1 | Activin A receptor type 1C. (258 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (221 aa) |
| | epc1 | Enhancer of polycomb homolog. (767 aa) |
| | nabp2 | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity). (203 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3060 aa) |
| | CDC45 | Cell division cycle 45. (569 aa) |
| | rpa2 | Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (278 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (221 aa) |
| | aunip | SH3-domain binding protein 5. (316 aa) |
| | rec8 | Malate dehydrogenase, cytoplasmic. (584 aa) |
| | wrn | Cell death-inducing p53-target protein 1. (1432 aa) |
| | ap5s1 | HEPACAM family member 2. (248 aa) |
| | rpa1 | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa) |
| | ankle1 | Uncharacterized protein. (1380 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | LOC100145100 | Trans-2-enoyl-CoA reductase, mitochondrial. (336 aa) |
| | rad51c-2 | RECA_2 domain-containing protein. (121 aa) |
| | LOC101733542 | MMS22L_N domain-containing protein. (495 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (930 aa) |
| | arf3-2 | ADP ribosylation factor 3. (1043 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | rnf138 | Uncharacterized protein. (222 aa) |
| | rad54b | Uncharacterized protein. (897 aa) |
| | hepacam2 | Thyroid peroxidase. (572 aa) |
| | brca1 | Leucine rich repeat containing 18. (1655 aa) |
| | smc6-2 | Spastin. (1128 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (630 aa) |
| | mcm5 | DNA replication licensing factor mcm5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (708 aa) |
| | LOC100496941 | SMC_N domain-containing protein. (1122 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (927 aa) |
| | smc6 | Importin 8. (1124 aa) |
| | mbtd1 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4 (By similarity). (651 aa) |
| | nucks1 | Nuclear casein kinase and cyclin-dependent kinase substrate 1. (291 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | FANCM | FA complementation group M. (2232 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2555 aa) |
| | swi5 | DNA repair protein SWI5 homolog; Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination. (105 aa) |
| | rfwd3 | Heat shock 70 kDa protein 14. (752 aa) |
| | mcm9 | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. In eggs, required for MCM2-7 loading onto chromatin during DNA replication. Probably not required for DNA replication in other cells (By similarity). (1126 aa) |
| | spidr | Kiaa0319-like. (924 aa) |
| | rad51d | RAD51-like 3 (S. cerevisiae). (320 aa) |
| | mus81 | Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (612 aa) |
| | rad51c | Malignant T-cell-amplified sequence 1. (369 aa) |
| | recql4 | Integrator complex subunit 10. (1463 aa) |
| | sem1 | Split hand/foot malformation (Ectrodactyly) type 1. (71 aa) |
| | mcm8 | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. In eggs, required for elongation during DNA replication by facilitating the recruitment of rpa2/rpa34 and stimulating the processivity of DNA polymerases at replication [...] (843 aa) |
| | rpa3 | Solute carrier family 1 member 3. (121 aa) |
| | dmc1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (322 aa) |
| | mcm2 | DNA replication licensing factor mcm2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (903 aa) |
| | mcm3-2 | Zygotic DNA replication licensing factor mcm3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute diff [...] (809 aa) |
| | exd2 | Phospholipase A2 group IB. (642 aa) |
| | poll | Malectin. (577 aa) |
| | wdr48 | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (709 aa) |
| | mcm6 | Maternal DNA replication licensing factor mcm6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] (836 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | rps3a | 40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (264 aa) |
| | mcm4 | DNA replication licensing factor mcm4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (910 aa) |
| | xrcc1 | Uncharacterized protein. (632 aa) |
| | brca2 | StAR related lipid transfer domain containing 9. (3138 aa) |
| | SMC5 | Structural maintenance of chromosomes 5. (1069 aa) |
| | NIPBL | Nipped-B protein. (2938 aa) |
| | blm | Uncharacterized protein. (1365 aa) |
| | recql | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (648 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (751 aa) |
| | slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (277 aa) |
| | HELQ | Helicase, POLQ like. (1000 aa) |
| | LOC100497907 | Cyclin D-type binding-protein 1. (587 aa) |
| | zswim7 | Zinc finger SWIM-type containing 7. (137 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (807 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1021 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1695 aa) |
| | meiob | Solute carrier family 12 (potassium/chloride transporter), member 4. (480 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1417 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa) |
| | INIP | INTS3 and NABP interacting protein. (128 aa) |
| | ppp4c | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes; Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. (307 aa) |
