STRINGSTRING
polk polk REV3L REV3L pclaf pclaf c17orf53 c17orf53 arl1-2 arl1-2 ENSXETP00000005412 ENSXETP00000005412 POLA1 POLA1 pcna pcna wrnip1 wrnip1 SPATA22 SPATA22 faap20 faap20 zbtb1 zbtb1 vcp vcp primpol primpol pold3 pold3 pold1 pold1 pole2 pole2 LOC105948375 LOC105948375 LOC105948377 LOC105948377 dtl dtl cdkn2d cdkn2d pole pole parp10 parp10 LOC101732407.1 LOC101732407.1 poli poli poldip2 poldip2 wrn wrn rev1 rev1 ptpmt1 ptpmt1 sirt1 sirt1 pold2 pold2 sprtn sprtn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
polkSEC31 homolog A, COPII coat complex component. (865 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa)
pclafPCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number (By similarity). (125 aa)
c17orf53Ankyrin repeat and SOCS box containing 16. (559 aa)
arl1-2SprT-like domain-containing protein. (248 aa)
ENSXETP00000005412SprT-like domain-containing protein. (263 aa)
POLA1DNA polymerase. (1462 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
wrnip1FGFR1 oncogene partner 2 homolog. (578 aa)
SPATA22Spermatogenesis associated 22. (283 aa)
faap20Uncharacterized protein. (289 aa)
zbtb1CCR4-NOT transcription complex subunit 6-like. (685 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive qua [...] (812 aa)
primpolUbiquitin protein ligase E3 component n-recognin 2. (182 aa)
pold3Ribosomal protein L28. (538 aa)
pold1DNA polymerase. (1191 aa)
pole2Uncharacterized protein. (572 aa)
LOC105948375SprT-like domain-containing protein. (233 aa)
LOC105948377Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (199 aa)
dtlDenticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (750 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (P19, inhibits CDK4). (161 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2298 aa)
parp10Poly [ADP-ribose] polymerase. (621 aa)
LOC101732407.1SprT-like domain-containing protein. (190 aa)
poliNeuronal guanine nucleotide exchange factor. (742 aa)
poldip2Serine hydrolase-like (pseudogene). (403 aa)
wrnCell death-inducing p53-target protein 1. (1432 aa)
rev1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1235 aa)
ptpmt1Protein tyrosine phosphatase, mitochondrial 1. (270 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
pold2Uncharacterized protein. (499 aa)
sprtnSprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated pcna; Belongs to the Spartan family. (436 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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