STRINGSTRING
gli3 gli3 sirt7 sirt7 GLI1 GLI1 bmp2 bmp2 bmp6 bmp6 kazald1 kazald1 ADAR ADAR sox1 sox1 RUNX3 RUNX3 ccn1 ccn1 zcchc4 zcchc4 clec3b clec3b gata1 gata1 fstl3 fstl3 mmp9.1 mmp9.1 wnt3a wnt3a lef1 lef1 pdlim7 pdlim7 LOC101731015 LOC101731015 igf3 igf3 MYOC MYOC SUCO SUCO runx1 runx1 CLEC11A CLEC11A slc26a2 slc26a2 ppargc1b ppargc1b polr2f-2 polr2f-2 snai2 snai2 mef2d mef2d prickle1-2 prickle1-2 calcr calcr TNFSF11 TNFSF11 sf1 sf1 bmp4 bmp4 ecm1 ecm1 phospho2 phospho2 KLF10 KLF10 runx2 runx2 atf4 atf4 BMPR1A BMPR1A dhh dhh NF1 NF1 mn1 mn1 lrp5 lrp5 ANKH ANKH tgfb1 tgfb1 SOX8 SOX8 TMEM119 TMEM119 pkdcc.2 pkdcc.2 zbtb16 zbtb16 dlx5 dlx5 igf2 igf2 snx10 snx10 lgr4 lgr4 bglap bglap cthrc1 cthrc1 asf1a asf1a zmpste24 zmpste24 zhx2 zhx2 TAPT1 TAPT1 nog nog DHX36 DHX36 mmp14 mmp14 CREB3L1 CREB3L1 TNFRSF11A TNFRSF11A BCL2 BCL2 adamts12 adamts12 thbs3 thbs3 INPPL1 INPPL1 twsg1 twsg1 sp3 sp3 LOC100487954 LOC100487954 ADAMTS7 ADAMTS7 junb junb clec3a clec3a wwox wwox ift80 ift80 shh shh ext2 ext2 ibsp ibsp SORT1 SORT1 nab2 nab2 bmp3 bmp3 mapk14 mapk14 eif2ak3 eif2ak3 sema4d sema4d msx2 msx2 hand2 hand2 ahsg ahsg snai1 snai1 nog2 nog2 fbxl15 fbxl15 bmpr1b bmpr1b pkdcc.1 pkdcc.1 ercc2 ercc2 myf5 myf5 ptn ptn gdf10 gdf10 glis1 glis1 ctnnb1 ctnnb1 tp53inp2 tp53inp2 nppc nppc ENSXETP00000044071 ENSXETP00000044071 LOC100490019 LOC100490019 smad1 smad1 wnt3 wnt3 PTHLH PTHLH bmp8 bmp8 TNN TNN b3galnt2 b3galnt2 MESD MESD PHEX PHEX PHOSPHO1 PHOSPHO1 pex7 pex7 IHH IHH cbfb cbfb BMPR2 BMPR2 SMO SMO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gli3Centrosomal protein 164kDa. (1566 aa)
sirt7Deacetylase sirtuin-type domain-containing protein. (408 aa)
GLI1GLI family zinc finger 1. (1371 aa)
bmp2Armadillo like helical domain containing 3. (398 aa)
bmp6Enhancer of mRNA decapping 4. (441 aa)
kazald1Phospholipase C beta 1. (301 aa)
ADARAdenosine deaminase RNA specific. (1119 aa)
sox13-phosphoinositide dependent protein kinase 1. (663 aa)
RUNX3Runt-related transcription factor. (396 aa)
ccn1Histone deacetylase 2. (376 aa)
zcchc4rRNA N6-adenosine-methyltransferase ZCCHC4; rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. (487 aa)
clec3bC-type lectin domain family 3, member B. (198 aa)
gata1GATA-binding protein 1. (363 aa)
fstl3Follistatin-like 3 (Secreted glycoprotein). (255 aa)
mmp9.1Uncharacterized protein. (692 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
lef1HMG box domain-containing protein. (415 aa)
pdlim7Rho guanine nucleotide exchange factor 40. (521 aa)
LOC101731015Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
igf3Aldehyde dehydrogenase 1 family member B1. (126 aa)
MYOCMyocilin. (499 aa)
SUCOSUN domain containing ossification factor. (1232 aa)
runx1Runt-related transcription factor. (522 aa)
CLEC11AC-type lectin domain containing 11A. (341 aa)
slc26a2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (711 aa)
ppargc1bAcylphosphatase-1. (937 aa)
polr2f-2Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (115 aa)
snai2Snail homolog 2 (Drosophila). (266 aa)
mef2dMADS-box domain-containing protein. (496 aa)
prickle1-2Peroxisomal trans-2-enoyl-CoA reductase. (136 aa)
calcrPeptidylprolyl isomerase domain and WD repeat containing 1; Belongs to the G-protein coupled receptor 2 family. (320 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (290 aa)
sf1Uncharacterized protein. (674 aa)
bmp4Zinc finger, HIT-type-containing 6. (469 aa)
ecm1O-phosphoseryl-tRNA(Sec) selenium transferase. (455 aa)
phospho2Probable phosphatase phospho2; Probable phosphatase; Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. (238 aa)
KLF10Kruppel like factor 10. (465 aa)
runx2Runt-related transcription factor. (468 aa)
atf4Activating transcription factor 4 (Tax-responsive enhancer element B67). (343 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa)
dhhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
NF1Neurofibromin 1. (2812 aa)
mn1Cytochrome P450 family 11 subfamily B member 2. (1210 aa)
lrp5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1634 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (529 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
SOX8SRY-box transcription factor 8. (466 aa)
TMEM119Transmembrane protein 119. (287 aa)
pkdcc.2PIP49_C domain-containing protein. (241 aa)
zbtb16Collagen, type IX, alpha 3. (660 aa)
dlx5Nuclear factor of activated T cells 3. (298 aa)
igf2IlGF domain-containing protein. (217 aa)
snx10Seryl-tRNA synthetase 2, mitochondrial. (171 aa)
lgr4Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (956 aa)
bglapOsteocalcin; Binds strongly to apatite and calcium. (101 aa)
cthrc1Diacylglycerol kinase, zeta. (235 aa)
asf1aPhosphatase and tensin homolog. (77 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
zhx2TBC1 domain family member 31. (1872 aa)
TAPT1Transmembrane anterior posterior transformation 1. (549 aa)
nogNoggin; Belongs to the noggin family. (222 aa)
DHX36DEAH-box helicase 36. (1006 aa)
mmp14ZnMc domain-containing protein. (622 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (467 aa)
TNFRSF11ATNF receptor superfamily member 11a. (579 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
adamts12ADAM metallopeptidase domain 10. (1540 aa)
thbs3Uncharacterized protein. (850 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (925 aa)
twsg1Uncharacterized protein. (339 aa)
sp3Zona pellucida glycoprotein 3 (sperm receptor), gene 2. (731 aa)
LOC100487954Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1561 aa)
junbBZIP domain-containing protein. (307 aa)
clec3aSec1 family domain containing 1. (193 aa)
wwoxRUNX family transcription factor 1. (381 aa)
ift80Intraflagellar transport 80 homolog. (779 aa)
shhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (404 aa)
ext2Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (723 aa)
ibspApoptosis resistant E3 ubiquitin protein ligase 1. (247 aa)
SORT1Sortilin. (801 aa)
nab2Chromodomain helicase DNA binding protein 3. (505 aa)
bmp3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (458 aa)
mapk14Mitogen-activated protein kinase. (361 aa)
eif2ak3Carnitine palmitoyltransferase 1A (liver) like. (929 aa)
sema4dKeratin 70; Belongs to the semaphorin family. (862 aa)
msx2Cerebellin 2 precursor. (256 aa)
hand2Hand2 protein. (210 aa)
ahsgAlpha-2-HS-glycoprotein. (331 aa)
snai1Uncharacterized protein. (336 aa)
nog2Noggin; Belongs to the noggin family. (218 aa)
fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway). Required for dorsal/ventral pattern formation (By similarity; Belongs to the FBXL15 family. (298 aa)
bmpr1bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
pkdcc.1Heterogeneous nuclear ribonucleoprotein L. (457 aa)
ercc2Epoxide hydrolase 3. (760 aa)
myf5Myogenic factor. (255 aa)
ptnGlycine receptor alpha 3. (190 aa)
gdf10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (442 aa)
glis1Uncharacterized protein. (330 aa)
ctnnb1Dynactin subunit 5. (788 aa)
tp53inp2Neurofibromin 1. (225 aa)
nppcUncharacterized protein. (128 aa)
ENSXETP00000044071Peptidase_M10 domain-containing protein. (159 aa)
LOC100490019Zinc finger MIZ-type containing 2. (472 aa)
smad1Mothers against decapentaplegic homolog. (464 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PTHLHParathyroid hormone like hormone. (169 aa)
bmp8TGF_BETA_2 domain-containing protein. (419 aa)
TNNTenascin N. (1093 aa)
b3galnt2UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation (By similarity); Belongs to the glycosyltransferase 31 family. (534 aa)
MESDMesoderm development LRP chaperone. (212 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (733 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (245 aa)
pex7Ring finger protein 157. (354 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
cbfbOlfactory receptor family 1 subfamily S member 1 (gene/pseudogene). (174 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (815 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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