STRINGSTRING
prickle1 prickle1 cthrc1 cthrc1 fzd3 fzd3 RPGRIP1L RPGRIP1L TP63 TP63 astn2 astn2 rtn4rl1-3 rtn4rl1-3 intu intu fuz fuz dvl2 dvl2 nphp1 nphp1 brsk1 brsk1 exoc5 exoc5 BRSK2 BRSK2 TTC8 TTC8 wnt9b.2 wnt9b.2 vangl2 vangl2 wnt9b wnt9b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prickle1Prickle-like protein 1; Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Regulates the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Essential for gastrulation cell movements, cooperating with dvl2/dsh to activate jnk. Acts together with tes to control axial elongation (By similarity). (871 aa)
cthrc1Diacylglycerol kinase, zeta. (235 aa)
fzd3Developmentally regulated GTP binding protein 1; Belongs to the G-protein coupled receptor Fz/Smo family. (664 aa)
RPGRIP1LRPGRIP1 like. (1266 aa)
TP63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (662 aa)
astn2Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative). (1274 aa)
rtn4rl1-3Reticulon 4 receptor-like 1. (414 aa)
intuProtein inturned; Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies. Controls the localization of both rhoa and [...] (953 aa)
fuzProtein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May control the organization of the apical actin cytoskeleton, which is essential for the normal orientation of elongating ciliary microtubules. (418 aa)
dvl2Segment polarity protein dishevelled homolog DVL-2; Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta- catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin- related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along [...] (316 aa)
nphp1Nuclear factor I C. (687 aa)
brsk1F-box and leucine-rich repeat protein 7. (764 aa)
exoc5Lipolysis stimulated lipoprotein receptor. (708 aa)
BRSK2Protein kinase domain-containing protein. (806 aa)
TTC8Tetratricopeptide repeat domain 8. (516 aa)
wnt9b.2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
vangl2Vang-like protein 2; Has a role in non-canonical Wnt/planar cell polarity (PCP) signaling; can recruite dvl/dsh and prickle from the cytoplasm to the plasma membrane. Acts in a PCP complex to regulate the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Regulates convergent extension in both dorsal mesoderm and neural tissue without affecting cell fate. Regulates neural fold closure during neurulation. May be required for cell surface localization of fzd3 and fzd6 in the inner ear (By similarity). (521 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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