STRINGSTRING
ddx43-2 ddx43-2 lrwd1 lrwd1 fgf7 fgf7 DLL4 DLL4 Lrg1 Lrg1 mydgf mydgf BMPR2 BMPR2 sirt1 sirt1 cav1 cav1 cav2 cav2 TIE1 TIE1 ITGA4 ITGA4 itgb3 itgb3 cav3.1 cav3.1 flt1 flt1 VIP VIP kdrl kdrl jcad jcad cav3.2 cav3.2 adam17 adam17 synj2bp synj2bp tgfbr1 tgfbr1 ATOH8 ATOH8 vegfb vegfb aplnr aplnr THBS1 THBS1 acvrl1 acvrl1 lep lep flt4 flt4 jund.2 jund.2 LOC100487812 LOC100487812 ENSXETP00000031289 ENSXETP00000031289 aggf1 aggf1 zhx2 zhx2 fgfbp1 fgfbp1 fut1 fut1 rptor rptor aimp1 aimp1 atp5f1a atp5f1a il10 il10 ccr2 ccr2 sp1 sp1 agtr1 agtr1 igf2 igf2 ENSXETP00000022548 ENSXETP00000022548 vegfa vegfa dbh dbh apln apln sulf1 sulf1 rgcc rgcc stat3.1 stat3.1 pdgfb-2 pdgfb-2 stat3.2 stat3.2 NF1 NF1 krit1 krit1 sirt6 sirt6 MMRN2 MMRN2 ecm1 ecm1 bmp4 bmp4 TNMD TNMD vash1 vash1 scg2 scg2 VEGFC VEGFC fut2 fut2 VEGFD VEGFD nr4a1 nr4a1 prok2 prok2 prok1 prok1 JUN JUN htr2b htr2b vash2 vash2 apela apela kdr kdr bmp6 bmp6 bmp2 bmp2 tnf tnf
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ddx43-2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (327 aa)
lrwd1Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity); Belongs to the LRWD1 family. (691 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
Lrg1LRRCT domain-containing protein. (336 aa)
mydgfYES proto-oncogene 1, Src family tyrosine kinase. (158 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1131 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1030 aa)
itgb3Integrin beta; Belongs to the integrin beta chain family. (800 aa)
cav3.1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (155 aa)
flt1Keratin 18, gene 2. (970 aa)
VIPVasoactive intestinal peptide. (202 aa)
kdrlUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1015 aa)
jcadLegumain. (1096 aa)
cav3.2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
adam17Monooxygenase, DBH-like 2, pseudogene. (834 aa)
synj2bpSynj2bp protein. (145 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ATOH8Atonal bHLH transcription factor 8. (246 aa)
vegfbBradykinin receptor B2. (251 aa)
aplnrApelin receptor; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis [...] (363 aa)
THBS1Thrombospondin 1. (1188 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (490 aa)
lepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
flt4Transient receptor potential cation channel subfamily M member 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1364 aa)
jund.2mRNA export factor. (448 aa)
LOC100487812L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (342 aa)
ENSXETP00000031289L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (310 aa)
aggf1Uncharacterized protein. (709 aa)
zhx2TBC1 domain family member 31. (1872 aa)
fgfbp1Protein phosphatase, Mg2+/Mn2+ dependent 1L. (224 aa)
fut1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (355 aa)
rptorWD_REPEATS_REGION domain-containing protein. (1356 aa)
aimp1tRNA-binding domain-containing protein. (313 aa)
atp5f1aATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
il10Activating transcription factor 6. (172 aa)
ccr21-acylglycerol-3-phosphate O-acyltransferase 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
sp1Nuclear receptor subfamily 2 group E member 3. (747 aa)
agtr1Agtr1.2 protein; Belongs to the G-protein coupled receptor 1 family. (355 aa)
igf2IlGF domain-containing protein. (217 aa)
ENSXETP00000022548IL12p40_C domain-containing protein. (249 aa)
vegfaGID complex subunit 8; Belongs to the PDGF/VEGF growth factor family. (311 aa)
dbhEctodermal-neural cortex (with BTB-like domain), gene 2. (615 aa)
aplnLOC100135238 protein. (76 aa)
sulf1Uncharacterized protein. (1145 aa)
rgccDual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa)
stat3.1Signal transducer and activator of transcription. (715 aa)
pdgfb-2Frizzled related protein; Belongs to the PDGF/VEGF growth factor family. (240 aa)
stat3.2STAT_int domain-containing protein. (408 aa)
NF1Neurofibromin 1. (2812 aa)
krit1Uncharacterized protein. (744 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6. (331 aa)
MMRN2Multimerin 2. (765 aa)
ecm1O-phosphoseryl-tRNA(Sec) selenium transferase. (455 aa)
bmp4Zinc finger, HIT-type-containing 6. (469 aa)
TNMDTenomodulin. (290 aa)
vash1Serine incorporator 5. (346 aa)
scg2BRX1, biogenesis of ribosomes. (624 aa)
VEGFCVascular endothelial growth factor C. (407 aa)
fut2L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (342 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (333 aa)
nr4a1Nuclear receptor subfamily 4, group A, member 1. (577 aa)
prok2Neurofilament heavy. (209 aa)
prok1Receptor tyrosine kinase-like orphan receptor 1. (106 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (312 aa)
htr2bRas homolog family member C. (478 aa)
vash2Missing oocyte, meiosis regulator, homolog. (354 aa)
apelaEndoplasmic reticulum-Golgi intermediate compartment protein 3. (54 aa)
kdrTransglutaminase 6; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
bmp6Enhancer of mRNA decapping 4. (441 aa)
bmp2Armadillo like helical domain containing 3. (398 aa)
tnfThyrotropin-releasing hormone receptor 3. (227 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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