STRINGSTRING
sufu sufu med1l med1l mdm4 mdm4 NSD2 NSD2 SMAD6 SMAD6 SMAD7 SMAD7 npy5r npy5r ccn1 ccn1 nprl3 nprl3 taf1b taf1b gja5 gja5 Tnni1 Tnni1 tnni3 tnni3 DLL4 DLL4 hectd1 hectd1 sema3c sema3c BMPR2 BMPR2 greb1l greb1l greb1 greb1 hand1 hand1 myocd myocd zfpm1 zfpm1 gata3 gata3 ednra ednra smc2-2 smc2-2 ptcd2 ptcd2 tnnc1 tnnc1 tgfbr1 tgfbr1 hand2 hand2 nkx2-5 nkx2-5 STRA6 STRA6 rtn4rl1-3 rtn4rl1-3 matr3 matr3 slit2 slit2 smad4.1 smad4.1 tmem65 tmem65 frs2-2 frs2-2 KCNK2 KCNK2 slit3 slit3 CNTRL CNTRL cpe cpe zmpste24 zmpste24 eng eng tgfb1 tgfb1 tbx5 tbx5 NPY2R NPY2R sfrp2 sfrp2 sall4 sall4 jag1 jag1 tgfbr2 tgfbr2 prdm1 prdm1 acvr1 acvr1 zfpm2 zfpm2 dctn5 dctn5 sav1 sav1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sufuSuppressor of fused homolog. (506 aa)
med1lMediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (678 aa)
mdm4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (474 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1308 aa)
SMAD6Mothers against decapentaplegic homolog. (352 aa)
SMAD7Mothers against decapentaplegic homolog. (382 aa)
npy5rNeuropeptide Y receptor Y5. (448 aa)
ccn1Histone deacetylase 2. (376 aa)
nprl3Insulin-like growth factor-binding protein complex acid labile subunit-like. (580 aa)
taf1bTATA box-binding protein-associated factor RNA polymerase I subunit B; Belongs to the G-protein coupled receptor 1 family. (368 aa)
gja5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (364 aa)
Tnni1Uncharacterized protein. (152 aa)
tnni3Transmembrane protein 256. (245 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (679 aa)
hectd1Fibrillarin. (2580 aa)
sema3cMICAL-like 2; Belongs to the semaphorin family. (753 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa)
greb1lUncharacterized protein. (1970 aa)
greb1Pecanex 4. (1898 aa)
hand1Glycogen synthase kinase 3 beta. (213 aa)
myocdYip1 domain family member 1. (956 aa)
zfpm1C-terminal Src kinase. (1214 aa)
gata3Uncharacterized protein. (454 aa)
ednraEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (414 aa)
smc2-2Structural maintenance of chromosomes 2. (1957 aa)
ptcd2Uncharacterized protein. (382 aa)
tnnc1CTD small phosphatase like. (161 aa)
tgfbr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
hand2Hand2 protein. (210 aa)
nkx2-5Toll-like receptor12. (300 aa)
STRA6Stimulated by retinoic acid 6. (637 aa)
rtn4rl1-3Reticulon 4 receptor-like 1. (414 aa)
matr3Transcription factor 3. (892 aa)
slit2ATPase family, AAA domain containing 3A. (1564 aa)
smad4.1Mothers against decapentaplegic homolog. (579 aa)
tmem65Uncharacterized protein. (224 aa)
frs2-2Frs2 protein. (509 aa)
KCNK2Potassium two pore domain channel subfamily K member 2. (347 aa)
slit3ZXD family zinc finger C. (1519 aa)
CNTRLCentriolin. (2247 aa)
cpeUncharacterized protein. (467 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
engUncharacterized protein. (622 aa)
tgfb1Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
tbx5T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters. (520 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (408 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
sall4Sal-like 4. (1067 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
tgfbr2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (728 aa)
prdm1ChaC, cation transport regulator homolog 2. (784 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (568 aa)
zfpm2GPI mannosyltransferase 1. (1151 aa)
dctn5Dynactin 4. (182 aa)
sav1Salvador homolog 1 (Drosophila). (388 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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