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| | smurf2 | Bcl2 modifying factor. (577 aa) |
| | hivep1 | Cytoplasmic polyadenylation element-binding protein 3. (2591 aa) |
| | lrrc32.1 | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled. (666 aa) |
| | inhbc.1 | Piwi-like RNA-mediated gene silencing 4. (367 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa) |
| | bmp2 | Armadillo like helical domain containing 3. (398 aa) |
| | smad9 | Mothers against decapentaplegic homolog. (466 aa) |
| | bmp6 | Enhancer of mRNA decapping 4. (441 aa) |
| | smpd5l | Uncharacterized protein. (523 aa) |
| | msx1 | Potassium channel, two pore domain subfamily K, member 18. (275 aa) |
| | INHBA | Inhibin subunit beta A. (411 aa) |
| | GDF7 | Growth differentiation factor 7. (414 aa) |
| | GLG1 | Golgi glycoprotein 1. (1148 aa) |
| | gdf6 | Erb-b2 receptor tyrosine kinase 3. (396 aa) |
| | smad2 | Mothers against decapentaplegic homolog. (467 aa) |
| | MTMR4 | Myotubularin related protein 4. (1093 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog. (352 aa) |
| | smad3 | Mothers against decapentaplegic homolog. (461 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (382 aa) |
| | usp15 | Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiqu [...] (982 aa) |
| | nlk | Serine/threonine-protein kinase NLK2; Negatively regulates Wnt/beta-catenin-signaling during development. Plays a role together with sox11 in neural induction during early embryogenesis. Involved in TGFbeta-mediated mesoderm induction in early embryos, acting downstream of map3k7/tak1 to phosphorylate stat3. Augments the rnf138/narf-directed ubiquitination and degradation of tcf/lef by enhancing the association of rnf138/narf and tcf/lef. Phosphorylates mef2a to play a role in anterior neural development, including eye formation (By similarity). (534 aa) |
| | rbm14 | Uncharacterized protein. (468 aa) |
| | fkbp8 | Peptidylprolyl isomerase. (408 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (312 aa) |
| | ventx1.2 | Homeobox protein vent1; Transcriptional repressor. Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation. Acts downstream of bmp4 to repress transcription of foxa4- B/XFD-1'. Binds to DNA with preference for the target sequence 5'- CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene (By similarity). Cooperates with vent2 to repress my [...] (262 aa) |
| | BMP10 | Bone morphogenetic protein 10. (421 aa) |
| | csgalnact1-2 | Chemerin chemokine-like receptor 1. (132 aa) |
| | bmp7.2 | Nuclear receptor subfamily 5 group A member 1. (436 aa) |
| | gdf5 | Growth differentiation factor 5. (496 aa) |
| | slc33a1 | Phospholipid phosphatase 3. (538 aa) |
| | ENSXETP00000010102 | TGF_BETA_2 domain-containing protein. (294 aa) |
| | gdf1 | Vg1. (361 aa) |
| | lef1 | HMG box domain-containing protein. (415 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (418 aa) |
| | acvr1b | Serine/threonine kinase 17a. (530 aa) |
| | ENSXETP00000011922 | Mapk-regulated corepressor-interacting protein 1. (101 aa) |
| | acvr1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (568 aa) |
| | SKI | SKI proto-oncogene. (719 aa) |
| | AMH | Anti-Mullerian hormone. (606 aa) |
| | chrd.1 | Chordin; Belongs to the chordin family. (942 aa) |
| | bmper | Uncharacterized protein. (741 aa) |
| | HJV | Hemojuvelin BMP co-receptor. (402 aa) |
| | acvr2b | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa) |
| | pxn | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (579 aa) |
| | fam83g | Glucosidase, alpha; neutral C. (949 aa) |
| | nodal | Ribosomal protein S12. (418 aa) |
| | mstn.2 | Ubiquitin associated protein 2. (374 aa) |
| | mstn.1 | Lin-37 DREAM MuvB core complex component. (369 aa) |
| | appl2 | Alveolar soft part sarcoma chromosome region, candidate 1. (664 aa) |
| | bmp4 | Zinc finger, HIT-type-containing 6. (469 aa) |
| | fos | V-fos FBJ murine osteosarcoma viral oncogene homolog. (368 aa) |
| | smurf1 | E3 ubiquitin-protein ligase. (748 aa) |
| | LOC100492768 | Peptidylprolyl isomerase. (424 aa) |
| | appl1 | K(lysine) acetyltransferase 8. (685 aa) |
| | tgfbr2 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (728 aa) |
| | nrros | Cytoskeleton associated protein 5. (679 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (528 aa) |
| | tab1 | Allograft inflammatory factor 1-like. (650 aa) |
| | JADE2 | Uncharacterized protein. (853 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (295 aa) |
| | stat3.2 | STAT_int domain-containing protein. (408 aa) |
| | pdcd4 | Uncharacterized protein. (486 aa) |
| | chst11 | Carbohydrate sulfotransferase. (352 aa) |
| | stat3.1 | Signal transducer and activator of transcription. (715 aa) |
| | rgmb | Acetoacetyl-CoA synthetase. (459 aa) |
| | lefty | Left-right determination factor. (365 aa) |
| | bmp7.1 | TGF_BETA_2 domain-containing protein. (425 aa) |
| | sec62-2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (461 aa) |
| | tgfb1 | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | INHBC | Inhibin subunit beta C. (340 aa) |
| | spart | MIT domain-containing protein. (592 aa) |
| | dlx5 | Nuclear factor of activated T cells 3. (298 aa) |
| | LOC101730723 | Fork-head domain-containing protein. (236 aa) |
| | LOC448531 | HGF activator. (260 aa) |
| | Smad6.2 | MH2 domain-containing protein. (206 aa) |
| | ENSXETP00000025869 | UPAR/Ly6 domain-containing protein. (117 aa) |
| | nlk.2 | Serine/threonine-protein kinase NLK2. (336 aa) |
| | bmp15 | Intraflagellar transport 74. (379 aa) |
| | admp | Novel protein similar to anti-dorsalizing morphogenic protein. (390 aa) |
| | bmp5 | Apoptosis antagonizing transcription factor. (449 aa) |
| | LOC101734414 | One cut homeobox 1, gene 2. (229 aa) |
| | eng | Uncharacterized protein. (622 aa) |
| | tmem100 | Serine protease 1. (132 aa) |
| | rnf111 | E3 ubiquitin-protein ligase arkadia; E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By [...] (981 aa) |
| | tgfb1i1 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (503 aa) |
| | ventx1.1 | Homeobox domain-containing protein. (278 aa) |
| | ventx3.1 | Ventx3.1 protein. (273 aa) |
| | ventx3.2 | Homeobox protein vex1; Transcriptional repressor. Acts in a ventral signaling pathway downstream of bmp4 to antagonize the Spemann organizer and ventrally pattern the embryonic mesoderm. Represses transcription of the dorsal genes gsc and otx2 (By similarity). (282 aa) |
| | mms19 | MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). (1048 aa) |
| | jund.2 | mRNA export factor. (448 aa) |
| | gdf3 | Derriere protein; Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1. Can exert long-range effects in the embryo (By similarity). (354 aa) |
| | smad4.1 | Mothers against decapentaplegic homolog. (579 aa) |
| | twsg1 | Uncharacterized protein. (339 aa) |
| | acvr1c | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa) |
| | cdh5 | Zinc finger RNA-binding protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa) |
| | INHBB | Inhibin subunit beta B. (131 aa) |
| | ddx5 | Uncharacterized protein; Belongs to the DEAD box helicase family. (618 aa) |
| | acvrl1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (490 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Upon TGF-beta induction, forms a transcriptionally active complex with smad2 and smad4 called activin- responsive factor 1 (ARF1), which binds a site on the mix-B/mix.2 promoter called the activin response element (ARE). Binds to activated smads and the ARE with much lower affinity than fast3. Necessary for the first steps in mesoderm specification, directly inducing mesodermal genes. Acts with fast3 to control the convergent extension movements of gastrulation. Binds to t [...] (515 aa) |
| | tspan2-2 | Adaptor related protein complex 1 subunit mu 1. (634 aa) |
| | PPM1L | Protein phosphatase, Mg2+/Mn2+ dependent 1L. (360 aa) |
| | fst | Chloride channel, voltage-sensitive 6. (343 aa) |
| | bmp3 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (458 aa) |
| | ATOH8 | Atonal bHLH transcription factor 8. (246 aa) |
| | hpgd | Armadillo repeat containing 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa) |
| | ism2 | AMOP domain-containing protein. (455 aa) |
| | tgfbr1 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa) |
| | Znf831 | Uncharacterized protein. (1264 aa) |
| | cldn5 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa) |
| | bmpr1b | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | skil | c-SKI_SMAD_bind domain-containing protein. (643 aa) |
| | smpd3 | Barttin CLCNK-type chloride channel accessory beta subunit. (659 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa) |
| | GDF2 | Growth differentiation factor 2. (410 aa) |
| | gdf10 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (442 aa) |
| | ncoa6-2 | USP domain-containing protein; Belongs to the peptidase C19 family. (2558 aa) |
| | bambi | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa) |
| | admp2 | TGF_BETA_2 domain-containing protein. (432 aa) |
| | foxf1 | Forkhead box protein F1; Probable transcription factor. Required for smooth muscle (visceral mesoderm) differentiation during gut development. Also required for normal proliferation of the lateral plate mesoderm. Acts as a downstream mediator of bmp4-signaling (By similarity). (373 aa) |
| | smad1 | Mothers against decapentaplegic homolog. (464 aa) |
| | nceh1 | Uncharacterized protein. (409 aa) |
| | acvr2a | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (522 aa) |
| | inha | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (371 aa) |
| | nodal5 | Polypeptide N-acetylgalactosaminyltransferase 7. (386 aa) |
| | nvl-2 | Nuclear VCP like. (393 aa) |
| | LOC101734231 | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (386 aa) |
| | LOC101734157 | TGF_BETA_2 domain-containing protein. (386 aa) |
| | nodal6 | TGF_BETA_2 domain-containing protein. (382 aa) |
| | bmp8 | TGF_BETA_2 domain-containing protein. (419 aa) |
| | WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (559 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (726 aa) |
| | b3galnt2 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation (By similarity); Belongs to the glycosyltransferase 31 family. (534 aa) |
| | sostdc1 | Transmembrane protein 52. (213 aa) |
| | cited1 | Crystallin alpha A. (142 aa) |
| | mettl23 | Methyltransferase like 23. (175 aa) |
| | cav2 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa) |
| | sirt1 | Thrombospondin-type laminin G domain and EAR repeats. (707 aa) |
| | tdgf1.3 | Cripto, FRL-1, cryptic family 1. (190 aa) |
| | tdgf1.2 | CFC domain-containing protein. (197 aa) |
| | tdgf1.1 | EGF-like domain-containing protein. (174 aa) |
| | gdf11.1 | ATR interacting protein. (425 aa) |
| | mreg | Melanoregulin; Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinosi [...] (270 aa) |
| | TGFBR3 | Transforming growth factor beta receptor 3. (864 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1053 aa) |
| | nodal-2 | Nodal homolog 3-C; Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp- signaling; Belongs to the TGF-beta family. (403 aa) |
| | nodal2 | Neurotrophic receptor tyrosine kinase 3. (405 aa) |
| | nodal1 | Nodal homolog; Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene c [...] (403 aa) |
| | gdf5-2 | Growth differentiation factor 5. (1420 aa) |
| | rgma | Pre-mRNA-splicing factor SPF27. (459 aa) |
| | ptprk | Estrogen related receptor gamma. (1462 aa) |
| | itgb6 | Integrin beta; Belongs to the integrin beta chain family. (782 aa) |
