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glul glul asnsd1 asnsd1 LOC100497030 LOC100497030 MTRR MTRR PLOD2 PLOD2 sephs1 sephs1 gls gls shmt2 shmt2 mri1 mri1 hao1 hao1 mafg mafg gad1.1 gad1.1 plod3 plod3 adi1 adi1 mtr mtr ADI1 ADI1 GLS2 GLS2 aass aass gad2 gad2 dpyd dpyd dhfr-2 dhfr-2 otc otc mthfr mthfr aasdhppt aasdhppt psat1 psat1 MGC75760 MGC75760 noxred1 noxred1 apip apip srr srr phgdh phgdh cth cth upb1 upb1 enoph1 enoph1 got1 got1 shmt1 shmt1 tha1p tha1p asl asl LOC100498257 LOC100498257 mtap mtap psph psph oat oat carnmt1-2 carnmt1-2 tmed8 tmed8 slc1a3 slc1a3 aldh18a1 aldh18a1 ilvbl ilvbl ass1 ass1 agxt2 agxt2 bhmt bhmt glul-2 glul-2 PYCR3 PYCR3 NAGS NAGS bcat2 bcat2 asns asns pah pah sdsl sdsl sds sds
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glulGlutamine synthetase. (371 aa)
asnsd1Glutamine amidotransferase type-2 domain-containing protein. (610 aa)
LOC100497030NIPA-like domain containing 3. (541 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (687 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (761 aa)
sephs1Selenide, water dikinase 1; Synthesizes selenophosphate from selenide and ATP. (392 aa)
glsSPOUT domain containing methyltransferase 1. (588 aa)
shmt2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (514 aa)
mri1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (354 aa)
hao1FMN hydroxy acid dehydrogenase domain-containing protein. (369 aa)
mafgPyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (377 aa)
gad1.1Matrix-remodelling-associated 5. (600 aa)
plod3Uncharacterized protein. (585 aa)
adi1EARP-interacting protein homolog; Belongs to the WD repeat EIPR1 family. (513 aa)
mtrMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
ADI11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (185 aa)
GLS2Glutaminase 2. (652 aa)
aassNIN1 (RPN12) binding protein 1 homolog. (964 aa)
gad2Peptidoglycan recognition protein 1. (588 aa)
dpydDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1028 aa)
dhfr-2DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (189 aa)
otcOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (351 aa)
mthfrMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (676 aa)
aasdhpptRas and Rab interactor 3. (308 aa)
psat1Transmembrane and coiled-coil domains 3. (392 aa)
MGC75760Hcy-binding domain-containing protein. (311 aa)
noxred1NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. (344 aa)
apipMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (239 aa)
srrLOC100144980 protein. (323 aa)
phgdhD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (509 aa)
cthSmall integral membrane protein 12. (400 aa)
upb1LOC100145317 protein. (383 aa)
enoph1Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (259 aa)
got1Aspartate aminotransferase. (485 aa)
shmt1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (485 aa)
tha1pBeta_elim_lyase domain-containing protein. (409 aa)
aslLOC100127798 protein. (464 aa)
LOC100498257StAR-related lipid transfer (START) domain containing 15; Belongs to the glutamine synthetase family. (397 aa)
mtapS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (282 aa)
psphUncharacterized protein. (251 aa)
oatPapilin, proteoglycan-like sulfated glycoprotein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (463 aa)
carnmt1-2Carnosine N-methyltransferase 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa)
tmed8Fucosyltransferase 9 (alpha (1,3) fucosyltransferase). (329 aa)
slc1a3Amino acid transporter. (542 aa)
aldh18a1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (802 aa)
ilvblUncharacterized protein; Belongs to the TPP enzyme family. (651 aa)
ass1Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues; Belongs to the argininosuccinate synthase family. (429 aa)
agxt2Recoverin, gene 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (508 aa)
bhmtBetaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). (438 aa)
glul-2Glutamine synthetase. (373 aa)
PYCR3Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (274 aa)
NAGSN-acetylglutamate synthase. (496 aa)
bcat2Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
asnsAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
pah3-hydroxy-3-methylglutaryl-CoA reductase. (450 aa)
sdslPALP domain-containing protein. (332 aa)
sdsDEAH-box helicase 15. (328 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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