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adk adk hprt1 hprt1 adss adss dpyd dpyd atic atic AK4 AK4 NT5C1A NT5C1A uprt uprt impdh2 impdh2 nt5c2 nt5c2 rfk rfk ENSXETP00000005678 ENSXETP00000005678 pld1-2 pld1-2 prps2 prps2 LOC100145149 LOC100145149 AK9 AK9 prps1 prps1 gart gart ampd2 ampd2 upp2 upp2 gda gda dhodh dhodh UCK1 UCK1 upb1 upb1 dck.2 dck.2 aprt aprt AMPD1 AMPD1 ak1 ak1 NT5E NT5E paics.1 paics.1 ppat ppat ak2 ak2 pfas pfas nt5dc1 nt5dc1 hexb-2 hexb-2 ampd3 ampd3 adssl1 adssl1 cdk14 cdk14 upp1 upp1 adsl adsl dck.1 dck.1 guk1 guk1 GMPS GMPS impdh1 impdh1 ada.2 ada.2 ada ada uck2 uck2 Uckl1 Uckl1 mpc2-2 mpc2-2 ak3 ak3 nt5dc4 nt5dc4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adkTransmembrane phosphoinositide 3-phosphatase and tensin homolog 2. (370 aa)
hprt1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (224 aa)
adssAdenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (477 aa)
dpydDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1028 aa)
aticMGS domain-containing protein. (607 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (231 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (364 aa)
uprtThiosulfate sulfurtransferase (rhodanese)-like domain containing 2. (291 aa)
impdh2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (594 aa)
nt5c2Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). (638 aa)
rfkRegulator of calcineurin 1. (154 aa)
ENSXETP00000005678Membrane associated ring-CH-type finger 9. (250 aa)
pld1-2Phospholipase D1. (919 aa)
prps2Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. (318 aa)
LOC100145149Fatty acid binding protein 3. (245 aa)
AK9Adenylate kinase 9. (1609 aa)
prps1Pribosyltran_N domain-containing protein. (322 aa)
gartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1016 aa)
ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (831 aa)
upp2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (316 aa)
gdaGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (478 aa)
dhodhDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (411 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (292 aa)
upb1LOC100145317 protein. (383 aa)
dck.2Dpy-19-like 4. (265 aa)
aprtAdenine phosphoribosyltransferase. (180 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (771 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (502 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (582 aa)
paics.1AIRC domain-containing protein. (490 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (235 aa)
pfasGlutamine amidotransferase type-1 domain-containing protein. (1351 aa)
nt5dc1Uncharacterized protein. (451 aa)
hexb-2Hexosaminidase B (beta polypeptide). (176 aa)
ampd3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa)
adssl1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. (468 aa)
cdk14Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway (By similarity). (469 aa)
upp1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (311 aa)
adslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (513 aa)
dck.1Dck protein. (265 aa)
guk1EF-hand calcium-binding domain 7. (233 aa)
GMPSGuanine monophosphate synthase. (763 aa)
impdh1Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (596 aa)
ada.2A_deaminase domain-containing protein. (415 aa)
adaAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (359 aa)
uck2Uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity). (261 aa)
Uckl1Uncharacterized protein. (176 aa)
mpc2-2Deoxycytidine kinase, gene 2. (477 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (221 aa)
nt5dc4TELO2 interacting protein 1. (535 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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