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NT5C1A NT5C1A ENSXETP00000005678 ENSXETP00000005678 pld1-2 pld1-2 ada ada ada.2 ada.2 impdh1 impdh1 GMPS GMPS guk1 guk1 adsl adsl adssl1 adssl1 ampd3 ampd3 hexb-2 hexb-2 nt5dc1 nt5dc1 pfas pfas ak2 ak2 ppat ppat paics.1 paics.1 NT5E NT5E ak1 ak1 AMPD1 AMPD1 aprt aprt gda gda ampd2 ampd2 gart gart AK9 AK9 LOC100145149 LOC100145149 impdh2 impdh2 AK4 AK4 mpc2-2 mpc2-2 ak3 ak3 nt5dc4 nt5dc4 adk adk hprt1 hprt1 adss adss atic atic nt5c2 nt5c2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NT5C1A5'-nucleotidase, cytosolic IA. (364 aa)
ENSXETP00000005678Membrane associated ring-CH-type finger 9. (250 aa)
pld1-2Phospholipase D1. (919 aa)
adaAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (359 aa)
ada.2A_deaminase domain-containing protein. (415 aa)
impdh1Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (596 aa)
GMPSGuanine monophosphate synthase. (763 aa)
guk1EF-hand calcium-binding domain 7. (233 aa)
adslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (513 aa)
adssl1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family. (468 aa)
ampd3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa)
hexb-2Hexosaminidase B (beta polypeptide). (176 aa)
nt5dc1Uncharacterized protein. (451 aa)
pfasGlutamine amidotransferase type-1 domain-containing protein. (1351 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (235 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
paics.1AIRC domain-containing protein. (490 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (582 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (502 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (771 aa)
aprtAdenine phosphoribosyltransferase. (180 aa)
gdaGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (478 aa)
ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (831 aa)
gartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1016 aa)
AK9Adenylate kinase 9. (1609 aa)
LOC100145149Fatty acid binding protein 3. (245 aa)
impdh2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (594 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (231 aa)
mpc2-2Deoxycytidine kinase, gene 2. (477 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (221 aa)
nt5dc4TELO2 interacting protein 1. (535 aa)
adkTransmembrane phosphoinositide 3-phosphatase and tensin homolog 2. (370 aa)
hprt1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (224 aa)
adssAdenylosuccinate synthetase isozyme 2 A; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (477 aa)
aticMGS domain-containing protein. (607 aa)
nt5c2Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). (638 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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