STRINGSTRING
gngt2 gngt2 STAC STAC ptpn4 ptpn4 cbwd2-2 cbwd2-2 stac3 stac3 TH TH blk blk gngt2.1 gngt2.1 frk frk gng7 gng7 gna11 gna11 gng5 gng5 gna13 gna13 gramd1a gramd1a traf5 traf5 ldlrap1 ldlrap1 gem gem KCNAB2 KCNAB2 ggt1-2 ggt1-2 tnk2 tnk2 SAMD12 SAMD12 htra2 htra2 gnaz gnaz ENSXETP00000012243 ENSXETP00000012243 gtpbp10 gtpbp10 ENSXETP00000013152 ENSXETP00000013152 gng3 gng3 snx9 snx9 FES FES gngt1 gngt1 racgap1 racgap1 acyp1 acyp1 gnb3 gnb3 tnk2l tnk2l osbpl2 osbpl2 snap25 snap25 hck hck srms srms ENSXETP00000019771 ENSXETP00000019771 LOC100491469 LOC100491469 myzap myzap ptk6 ptk6 fyn fyn GNG8 GNG8 gng10 gng10 th2 th2 src src acp1 acp1 PRMT8 PRMT8 gng13 gng13 jup jup mtss1l mtss1l FGR FGR TRAF2 TRAF2 syap1 syap1 gnb1 gnb1 plekha4 plekha4 ebna1bp2-4 ebna1bp2-4 litafd litafd gnas gnas nodal3.1 nodal3.1 gna15 gna15 exoc1 exoc1 LOC100489307 LOC100489307 aspscr1 aspscr1 dohh-2 dohh-2 prrx2-2 prrx2-2 ptk2b ptk2b gm2a gm2a LOC108644461 LOC108644461 ezr ezr mtss1.1 mtss1.1 styk1 styk1 rgs8 rgs8 kcnab1 kcnab1 tepsin tepsin ajap1 ajap1 errfi1 errfi1 esyt2 esyt2 nexmif nexmif slbp-2 slbp-2 gnb4 gnb4 cngb3-2 cngb3-2 zap70 zap70 gnat2 gnat2 gnai3 gnai3 rnf31 rnf31 HIP1 HIP1 syk syk usp30 usp30 PGM5 PGM5 gna14 gna14 gng2 gng2 gnaq gnaq mien1 mien1 LOC733841 LOC733841 traf1 traf1 SHANK3 SHANK3 lyn lyn fer fer nphs2 nphs2 ikbkb ikbkb yes1 yes1 esyt1 esyt1 farp1 farp1 poc1b poc1b g6pd g6pd chmp4b chmp4b STAC2 STAC2 shroom4 shroom4 traf3 traf3 cav2 cav2 cyld cyld gng12 gng12 CHMP4C CHMP4C PTK2 PTK2 gnai2 gnai2 gnat1 gnat1 BLK BLK litaf litaf gnai1 gnai1 racgap1.2 racgap1.2 gnao1 gnao1 ptpn3 ptpn3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gngt2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
STACSH3 and cysteine rich domain. (328 aa)
ptpn4Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (910 aa)
cbwd2-2COBW domain containing 1, gene 2. (87 aa)
stac3SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. (346 aa)
THTyrosine hydroxylase. (478 aa)
blkTyrosine-protein kinase. (497 aa)
gngt2.1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
frkTyrosine-protein kinase. (517 aa)
gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
gna11Guanine nucleotide binding protein (G protein), alpha 11 (Gq class). (359 aa)
gng5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
gna13LOC100145489 protein. (377 aa)
gramd1aNuclear transcription factor, X-box binding like 1. (650 aa)
traf5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (539 aa)
ldlrap1Zinc finger protein 238, gene 2. (309 aa)
gemPleckstrin homology and FYVE domain containing 2. (299 aa)
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (412 aa)
ggt1-2ML domain-containing protein. (222 aa)
tnk2ARFGEF family member 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1106 aa)
SAMD12Sterile alpha motif domain containing 12. (196 aa)
htra2Zic family member 4. (230 aa)
gnazCCR4-NOT transcription complex subunit 9. (355 aa)
ENSXETP00000012243LMWPc domain-containing protein. (91 aa)
gtpbp10GTP-binding protein 10; May be involved in the ribosome maturation process. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (397 aa)
ENSXETP00000013152Uncharacterized protein. (710 aa)
gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
snx9Sorting nexin. (585 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
gngt1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
racgap1Uncharacterized protein. (632 aa)
acyp1Acylphosphatase-1. (98 aa)
gnb3Zinc finger, BED-type-containing 8. (349 aa)
tnk2lChloride channel, voltage-sensitive 5; Belongs to the protein kinase superfamily. Tyr protein kinase family. (629 aa)
osbpl2Oxysterol-binding protein; Belongs to the OSBP family. (409 aa)
snap25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
hckTyrosine-protein kinase. (489 aa)
srmsTyrosine-protein kinase. (478 aa)
ENSXETP00000019771Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (246 aa)
LOC100491469Tyrosine-protein kinase. (493 aa)
myzapMyocardial zonula adherens protein; Belongs to the MYZAP family. (519 aa)
ptk6Tyrosine-protein kinase. (467 aa)
fynTyrosine-protein kinase. (538 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
th2Uncharacterized protein. (434 aa)
srcTyrosine-protein kinase. (557 aa)
acp1Collagen, type VIII, alpha 1. (157 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (396 aa)
gng13Guanine nucleotide binding protein (G protein), gamma 13. (67 aa)
jupUncharacterized protein. (750 aa)
mtss1lAcyl-CoA synthetase short-chain family member 2, gene 2. (764 aa)
FGRTyrosine-protein kinase. (522 aa)
TRAF2TNF receptor-associated factor. (481 aa)
syap1Synapse associated protein 1, SAP47 homolog. (364 aa)
gnb1Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
plekha4N-alpha-acetyltransferase 50. (1470 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
litafdLITAF domain-containing protein. (141 aa)
gnasATPase family AAA domain-containing protein 1. (292 aa)
nodal3.1Nodal homolog 3, gene 1. (75 aa)
gna15BCL2 associated athanogene 4. (256 aa)
exoc1Zinc finger protein 572. (906 aa)
LOC100489307Dynein, axonemal, heavy chain 2; Belongs to the peptidase C19 family. (757 aa)
aspscr1Cleavage and polyadenylation specific factor 3. (590 aa)
dohh-2Deoxyhypusine hydroxylase. (86 aa)
prrx2-2Uncharacterized protein. (931 aa)
ptk2bUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1017 aa)
gm2aGM2 ganglioside activator protein. (203 aa)
LOC108644461ML domain-containing protein. (195 aa)
ezrFERM domain-containing protein. (621 aa)
mtss1.1Gephyrin. (722 aa)
styk1Protein kinase domain-containing protein. (423 aa)
rgs8CLOCK-interacting pacemaker. (216 aa)
kcnab1Aldo_ket_red domain-containing protein. (429 aa)
tepsinFollistatin like 4. (649 aa)
ajap1Adherens junction-associated protein 1; May play a role in cell adhesion and cell migration. (390 aa)
errfi1CD53 molecule. (404 aa)
esyt2Glycerophosphodiester phosphodiesterase domain containing 5. (687 aa)
nexmifNeurite extension and migration facto. (945 aa)
slbp-2Uncharacterized protein. (84 aa)
gnb4LOC549706 protein. (327 aa)
cngb3-2Cyclic nucleotide gated channel beta 3. (704 aa)
zap70Tyrosine-protein kinase. (609 aa)
gnat2Uncharacterized protein. (354 aa)
gnai3Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
rnf31Uncharacterized protein. (1034 aa)
HIP1Huntingtin interacting protein 1. (737 aa)
sykTyrosine-protein kinase. (611 aa)
usp30Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN). (519 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (579 aa)
gna14Guanine nucleotide binding protein (G protein), alpha 14. (354 aa)
gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (145 aa)
gnaqGuanine nucleotide binding protein (G protein), q polypeptide. (359 aa)
mien1Uncharacterized protein. (95 aa)
LOC733841Adaptor related protein complex 1 subunit gamma 1. (331 aa)
traf1TNF receptor-associated factor. (379 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1850 aa)
lynTyrosine-protein kinase. (524 aa)
ferTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
nphs2Musashi RNA-binding protein 2. (376 aa)
ikbkbUncharacterized protein. (769 aa)
yes1Tyrosine-protein kinase. (565 aa)
esyt1Uncharacterized protein. (947 aa)
farp1Mucin 6, oligomeric mucus/gel-forming. (1040 aa)
poc1bPOC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (470 aa)
g6pdGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (655 aa)
chmp4bCharged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (222 aa)
STAC2SH3 and cysteine rich domain 2. (405 aa)
shroom4Splicing factor 3b subunit 5. (1721 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (160 aa)
cyldTLR4 interactor with leucine-rich repeats; Belongs to the peptidase C19 family. (975 aa)
gng12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CHMP4CCharged multivesicular body protein 4C. (222 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1122 aa)
gnai2Uncharacterized protein. (358 aa)
gnat1THAP domain containing 7. (350 aa)
BLKTyrosine-protein kinase. (503 aa)
litafLipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (188 aa)
gnai1Uncharacterized protein. (397 aa)
racgap1.2Bruton tyrosine kinase. (591 aa)
gnao1Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O. (354 aa)
ptpn3Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (901 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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