STRINGSTRING
ATR ATR lig4 lig4 kdm1a kdm1a bax bax map3k20 map3k20 LOC105946289 LOC105946289 brca2 brca2 elk1 elk1 sf1 sf1 chek2 chek2 ebna1bp2-4 ebna1bp2-4 zmpste24 zmpste24 BCL2 BCL2 xrcc6 xrcc6 cryab cryab wrn wrn prkaa1 prkaa1 XRCC2 XRCC2 ATM ATM fancd2 fancd2 tp53 tp53 clec3b-2 clec3b-2 polb polb ENSXETP00000051440 ENSXETP00000051440 XRCC5 XRCC5 myc myc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2608 aa)
lig4DNA ligase. (911 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (841 aa)
baxBCL2-associated X protein. (221 aa)
map3k20Uncharacterized protein. (790 aa)
LOC105946289Protein kinase domain-containing protein. (307 aa)
brca2StAR related lipid transfer domain containing 9. (3138 aa)
elk1Myosin, heavy chain 9, non-muscle. (414 aa)
sf1Uncharacterized protein. (674 aa)
chek2GDNF family receptor alpha-like. (504 aa)
ebna1bp2-4EBNA1 binding protein 2. (876 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (472 aa)
BCL2BCL2 apoptosis regulator. (293 aa)
xrcc6Ku domain-containing protein. (612 aa)
cryabMitochondrial ribosomal protein L23; Belongs to the small heat shock protein (HSP20) family. (173 aa)
wrnCell death-inducing p53-target protein 1. (1432 aa)
prkaa1Non-specific serine/threonine protein kinase. (571 aa)
XRCC2X-ray repair cross complementing 2. (221 aa)
ATMNon-specific serine/threonine protein kinase. (3060 aa)
fancd2Riboflavin kinase. (1432 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
clec3b-2Uncharacterized protein. (1371 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa)
ENSXETP00000051440Uncharacterized protein. (168 aa)
XRCC5X-ray repair cross complementing 5. (767 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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