STRINGSTRING
becn1 becn1 epm2a epm2a nprl2 nprl2 rab3gap1 rab3gap1 stk11 stk11 wdr24 wdr24 tpcn1 tpcn1 supt5h supt5h GSK3B GSK3B NOD1 NOD1 rbmx2-2 rbmx2-2 plpp4-2 plpp4-2 kdr kdr bcl2l11 bcl2l11 nprl3 nprl3 RNF152 RNF152 PAFAH1B2 PAFAH1B2 atf6 atf6 vps13d vps13d UFL1 UFL1 plekhf1 plekhf1 ulk1 ulk1 foxo3 foxo3 sptlc1 sptlc1 rb1cc1 rb1cc1 tsc2 tsc2 rhbg rhbg TRIM14 TRIM14 hspb8 hspb8 lrrk2 lrrk2 tmem173 tmem173 atg2a atg2a gsk3a gsk3a snx30 snx30 trim8 trim8 sesn2 sesn2 TP53INP1 TP53INP1 SMCR8 SMCR8 flcn flcn LOC100495031 LOC100495031 tsc1 tsc1 foxo1 foxo1 sesn3 sesn3 ambra1 ambra1 svip svip tert-2 tert-2 htt htt sesn1 sesn1 tfeb tfeb prkaa1 prkaa1 rnf31 rnf31 trim13 trim13 SCOC SCOC LRSAM1 LRSAM1 trim32 trim32 rab3gap2 rab3gap2 c9orf72 c9orf72 bnip3 bnip3 LDLRAD1 LDLRAD1 tmem59 tmem59 tp53inp2 tp53inp2 fbxo7 fbxo7 depdc5 depdc5 snx7 snx7 dcn dcn gje1 gje1 larp1 larp1 prkaa2 prkaa2 pip4k2a pip4k2a sirt1 sirt1 ROCK1 ROCK1 pip4k2b pip4k2b calcoco2 calcoco2 SH3BP4 SH3BP4 idi1-2 idi1-2 Zc3h12a Zc3h12a gpsm1 gpsm1 ULK2 ULK2 RIPK2 RIPK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
becn1Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but [...] (445 aa)
epm2aPeptidylprolyl isomerase B. (313 aa)
nprl2Uncharacterized protein. (383 aa)
rab3gap1Ribosomal protein S20. (914 aa)
stk11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (442 aa)
wdr24Rho/Rac guanine nucleotide exchange factor 18. (669 aa)
tpcn1DDB1 and CUL4 associated factor 15. (750 aa)
supt5hTranscription elongation factor SPT5. (1078 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (434 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (891 aa)
rbmx2-2RNA binding motif protein X-linked 2. (174 aa)
plpp4-2Phospholipid phosphatase 4. (563 aa)
kdrTransglutaminase 6; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
bcl2l11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
nprl3Insulin-like growth factor-binding protein complex acid labile subunit-like. (580 aa)
RNF152Ring finger protein 152. (203 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (259 aa)
atf6BZIP domain-containing protein. (644 aa)
vps13dTripartite motif-containing 13. (4362 aa)
UFL1UFM1 specific ligase 1. (794 aa)
plekhf1Uncharacterized protein. (269 aa)
ulk1Twinkle mtDNA helicase. (1050 aa)
foxo3Foxo3 protein. (653 aa)
sptlc1Aminotran_1_2 domain-containing protein. (476 aa)
rb1cc145 kDa calcium-binding protein. (1576 aa)
tsc2Mannosidase, alpha, class 1B, member 1. (1798 aa)
rhbgAmmonium transporter Rh type B; Functions as a specific ammonium transporter; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (468 aa)
TRIM14Tripartite motif containing 14. (429 aa)
hspb8Fibroblast growth factor 12; Belongs to the small heat shock protein (HSP20) family. (202 aa)
lrrk2Hes family bHLH transcription factor 2. (2514 aa)
tmem173Stimulator of interferon genes protein; Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy. Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol. Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome. Exhibits guanine base- specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP. Lacks the C-terminal tail (CTT) found [...] (329 aa)
atg2aAutophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family. (1997 aa)
gsk3aCACN subunit beta associated regulatory protein; Belongs to the protein kinase superfamily. (439 aa)
snx30Sorting nexin-30; May be involved in several stages of intracellular trafficking. (484 aa)
trim8Fin bud initiation factor homolog. (551 aa)
sesn2Uncharacterized protein. (415 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (237 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
flcnFolliculin; Belongs to the folliculin family. (579 aa)
LOC100495031Uncharacterized protein. (779 aa)
tsc1Distal-less homeobox 1. (1139 aa)
foxo1Forkhead box protein O1; Transcription factor. (626 aa)
sesn3Uncharacterized protein. (489 aa)
ambra1Suppressor of cytokine signaling 6. (1304 aa)
svipTransmembrane protein 128. (81 aa)
tert-2Myotubularin related protein 12. (243 aa)
httDihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex). (3110 aa)
sesn1Uncharacterized protein. (541 aa)
tfebTranscription factor EB. (433 aa)
prkaa1Non-specific serine/threonine protein kinase. (571 aa)
rnf31Uncharacterized protein. (1034 aa)
trim13Tripartite motif containing 13; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins (By similarity). (408 aa)
SCOCShort coiled-coil protein. (140 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (717 aa)
trim32LOC100124994 protein. (649 aa)
rab3gap2Uncharacterized protein. (1408 aa)
c9orf72Uncharacterized protein. (480 aa)
bnip3BCL2/adenovirus E1B 19kDa interacting protein 3. (202 aa)
LDLRAD1Low density lipoprotein receptor class A domain containing 1. (207 aa)
tmem59LOC100145768 protein. (323 aa)
tp53inp2Neurofibromin 1. (225 aa)
fbxo7F-box domain-containing protein. (499 aa)
depdc5DEP domain-containing protein. (1496 aa)
snx7Sorting nexin 7. (441 aa)
dcnDecorin; May affect the rate of fibrils formation. (364 aa)
gje1Gap junction protein epsilon 1. (132 aa)
larp1HTH La-type RNA-binding domain-containing protein. (1022 aa)
prkaa2Non-specific serine/threonine protein kinase. (564 aa)
pip4k2aChromosome 11 open reading frame 54. (470 aa)
sirt1Thrombospondin-type laminin G domain and EAR repeats. (707 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1365 aa)
pip4k2bLaeverin. (426 aa)
calcoco2Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting galectin-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). May play a role [...] (470 aa)
SH3BP4SH3 domain-binding protein 4; Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). (931 aa)
idi1-2Isopentenyl-diphosphate delta isomerase 1. (290 aa)
Zc3h12aC3H1-type domain-containing protein. (349 aa)
gpsm1Uncharacterized protein. (625 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1073 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (408 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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