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tp53 tp53 bnip3 bnip3 TMEM14A TMEM14A gclc gclc slc25a5 slc25a5 HGF HGF ENSXETP00000051440 ENSXETP00000051440 tspo tspo bok bok FXN FXN prelid1 prelid1 clk3-2 clk3-2 opa1 opa1 MUL1 MUL1 slc25a4 slc25a4 c11orf65 c11orf65 ghitm ghitm psmd10 psmd10 IGF1 IGF1 flcn flcn parl parl acaa2 acaa2 vat1 vat1 oma1 oma1 mpv17l mpv17l avp avp rnf41 rnf41
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
bnip3BCL2/adenovirus E1B 19kDa interacting protein 3. (202 aa)
TMEM14ATransmembrane protein 14A. (102 aa)
gclcGlutamate-cysteine ligase, catalytic subunit. (637 aa)
slc25a5Adenine nucleotide translocase; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
ENSXETP00000051440Uncharacterized protein. (168 aa)
tspoDLC1 Rho GTPase activating protein. (243 aa)
bokPlexin A1. (214 aa)
FXNFrataxin. (206 aa)
prelid1Janus kinase 3 (a protein tyrosine kinase, leukocyte). (216 aa)
clk3-2CDC like kinase 3. (159 aa)
opa1Cyclin-dependent kinase inhibitor 2B; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1010 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (463 aa)
slc25a4Solute carrier family 25 (Mitochondrial carrier; adenine nucleotide translocator), member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
c11orf65Helicase, POLQ like. (301 aa)
ghitmUncharacterized protein; Belongs to the BI1 family. (347 aa)
psmd10Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 10. (227 aa)
IGF1Insulin like growth factor 1. (153 aa)
flcnFolliculin; Belongs to the folliculin family. (579 aa)
parlRhomboid domain-containing protein. (364 aa)
acaa2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (408 aa)
vat1Ficolin 2. (456 aa)
oma1Transmembrane protein 19. (485 aa)
mpv17lUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (203 aa)
avpUncharacterized protein; Belongs to the vasopressin/oxytocin family. (161 aa)
rnf41Bardet-Biedl syndrome 5. (317 aa)
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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