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| | ccnf | Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily. (763 aa) |
| | LOC100498440 | Actinin alpha 4. (202 aa) |
| | fancd2 | Riboflavin kinase. (1432 aa) |
| | camlg-2 | Calcium modulating ligand. (1348 aa) |
| | nabp2 | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity). (203 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (355 aa) |
| | uimc1 | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquiti [...] (874 aa) |
| | prpf19 | Protein LSM14 homolog A. (440 aa) |
| | F7BLJ8_XENTR | Reverse transcriptase domain-containing protein. (730 aa) |
| | ctdsp2 | CTD (Carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1. (271 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa) |
| | babam1 | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] (328 aa) |
| | eme1 | ERCC4 domain-containing protein. (317 aa) |
| | PIDD1 | P53-induced death domain protein 1. (908 aa) |
| | wac | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway. (628 aa) |
| | fbxo5 | F-box only protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators cdc20 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. Required to arrest unfertilized eggs at metaphase of meiosis II, by preventing their release from metaphase of meiosis II, through inhibition of APC-dependent cyclin B destruction leading to stabilization of cyclin B-cdk1 complex activity. (391 aa) |
| | clec3b-2 | Uncharacterized protein. (1371 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1102 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa) |
| | rad17 | BCL2/adenovirus E1B 19kDa interacting protein 3-like. (682 aa) |
| | fbxo7 | F-box domain-containing protein. (499 aa) |
| | gper1 | Tripartite motif containing 55; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | setmar | Solute carrier family 26 (anion exchanger), member 11. (284 aa) |
| | ENSXETP00000044680 | Reverse transcriptase domain-containing protein. (657 aa) |
| | aurkb | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (375 aa) |
| | atf5.2 | Tubulin tyrosine ligase like11. (311 aa) |
| | chek1 | Basonuclin 2; Belongs to the protein kinase superfamily. (474 aa) |
| | atf5 | BZIP domain-containing protein. (311 aa) |
| | rps6ka2 | Ribosomal protein S6 kinase. (722 aa) |
| | rhno1 | Uncharacterized protein. (253 aa) |
| | LOC100485117 | Uncharacterized protein. (340 aa) |
| | fbxo31 | F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity). (551 aa) |
| | znf830 | Zinc finger protein 830; May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity. (357 aa) |
| | rint1 | 6-phosphogluconolactonase. (785 aa) |
| | gas1 | Uncharacterized protein. (289 aa) |
| | eif2ak4 | Uncharacterized protein. (1668 aa) |
| | nkx3-1 | Homeobox domain-containing protein. (211 aa) |
| | ctdsp1 | UbiA prenyltransferase domain-containing protein 1. (260 aa) |
| | ell-2 | Nanos-type domain-containing protein; Belongs to the nanos family. (290 aa) |
| | fhl1 | Four and a half LIM domains 1. (296 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (806 aa) |
| | cdk5rap3 | Uncharacterized protein. (505 aa) |
| | abraxas1 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX [...] (408 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1958 aa) |
| | taok1 | Exostosin glycosyltransferase 1. (1001 aa) |
| | hdgfl2 | Hepatoma-derived growth factor-related protein 2; Belongs to the HDGF family. (679 aa) |
| | bub1b | Uncharacterized protein. (1022 aa) |
| | timeless | Heat shock protein family H (Hsp110) member 1. (1287 aa) |
| | nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (806 aa) |
| | ctdspl | Transcriptional adapter 1. (278 aa) |
| | gpr132 | Abhydrolase domain containing 14B; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (888 aa) |
| | WAPL | WAPL cohesin release factor. (1178 aa) |
| | INIP | INTS3 and NABP interacting protein. (128 aa) |
| | KNTC1 | Kinetochore associated 1. (2236 aa) |
| | mad2l1bp | Poly(ADP-ribose) polymerase family member 6. (247 aa) |
| | taok2 | Prune homolog 2. (1083 aa) |
| | ccdc88a | Coiled-coil domain containing 88A. (58 aa) |
| | znf207 | Monocyte to macrophage differentiation-associated. (491 aa) |
| | INHBA | Inhibin subunit beta A. (411 aa) |
| | ccp110 | Hippocalcin-like protein 1. (962 aa) |
| | tpr | SOS Ras/Rho guanine nucleotide exchange factor 2. (2324 aa) |
| | mad2l1 | PIF1 5'-to-3' DNA helicase. (203 aa) |
| | mad1l1 | Neutrophil cytosolic factor 4. (605 aa) |
| | cradd.2 | Colony stimulating factor 2 receptor beta common subunit. (197 aa) |
| | nek2 | Matrix metallopeptidase 9. (444 aa) |
| | nek11 | NIMA (Never in mitosis gene a)-related expressed kinase 11. (601 aa) |
| | zwilch | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity). (597 aa) |
| | topbp1 | Protein phosphatase 1 regulatory inhibitor subunit 14B. (1515 aa) |
| | ENSXETP00000007878 | Reverse transcriptase domain-containing protein. (1326 aa) |
| | tom1l1 | Uncharacterized protein; Belongs to the TOM1 family. (477 aa) |
| | slc35g1 | Oxysterol binding protein like 3. (197 aa) |
| | fbxo43 | Eukaryotic translation initiation factor 3 subunit H. (682 aa) |
| | rbm14 | Uncharacterized protein. (468 aa) |
| | klhl22 | Kelch-like protein 22; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL22) ubiquitin ligase complex could mediate the monoubiquitination of PLK1 and regulate its activity in spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex may also be responsible for the ubiquitin-dependent proteasomal degradation of DEPDC5 and the activation of the TORC1 pathway. (665 aa) |
| | rbl1 | Uncharacterized protein. (1060 aa) |
| | xpc | Zona pellucida glycoprotein 4, gene 2. (1055 aa) |
| | rap1b | Ras-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa) |
| | spdl1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity); Belongs to the Spindly family. (611 aa) |
| | F7AA28_XENTR | Reverse transcriptase domain-containing protein. (996 aa) |
| | map3k20 | Uncharacterized protein. (790 aa) |
| | cdca7 | Cell division cycle associated 7. (434 aa) |
| | LOC105946289 | Protein kinase domain-containing protein. (307 aa) |
| | e2f1 | TEA domain family member 1 (SV40 transcriptional enhancer factor). (428 aa) |
| | ncln-2 | Nicalin. (1381 aa) |
| | eef1aknmt | Kiaa0859 protein. (693 aa) |
| | jade1 | Complement factor properdin. (833 aa) |
| | blm | Uncharacterized protein. (1365 aa) |
| | LOC101731574 | Bromo domain-containing protein. (84 aa) |
| | kat2a | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (779 aa) |
| | brd7 | Bromo domain-containing protein. (644 aa) |
| | kank2 | CLIP-associating protein 1. (887 aa) |
| | clk3-2 | CDC like kinase 3. (159 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (1100 aa) |
| | SUSD2 | Sushi domain containing 2. (1394 aa) |
| | hinfp | Uncharacterized protein. (479 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4102 aa) |
| | chek2 | GDNF family receptor alpha-like. (504 aa) |
| | cirbp-2 | Cold-inducible RNA-binding protein. (933 aa) |
| | gpnmb | Gpnmb protein. (587 aa) |
| | cpm-2 | Carboxypeptidase M. (1325 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (2185 aa) |
| | prmt2 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as histones. Involved in growth regulation. Involved in embryonic dorsal development. (503 aa) |
| | cdknx | Uncharacterized protein. (207 aa) |
| | AVEN | Apoptosis and caspase activation inhibitor. (298 aa) |
| | CCDC84 | Coiled-coil domain containing 84. (345 aa) |
| | nop53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (452 aa) |
| | macroh2a1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | rgcc | Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting), gene 2. (128 aa) |
| | zfp36l2 | mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-con [...] (362 aa) |
| | apbb2 | Uncharacterized protein. (756 aa) |
| | crlf3 | Fibronectin type-III domain-containing protein. (438 aa) |
| | tpra1 | LOC100170557 protein. (377 aa) |
| | ENSXETP00000021535 | Reverse transcriptase domain-containing protein. (1245 aa) |
| | E2F7 | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes. Acts as a promoter of sprouting angiogenes [...] (872 aa) |
| | babam2 | BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integri [...] (389 aa) |
| | eme2 | Probable crossover junction endonuclease EME2; Interacts with mus81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. (503 aa) |
| | mfsd11 | UNC93-like protein MFSD11. (436 aa) |
| | ATRX | ATRX chromatin remodeler. (2268 aa) |
| | atrip | Uncharacterized protein. (796 aa) |
| | plk1 | Serine/threonine-protein kinase PLK1; Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Phosphorylates tpx2 (By similarity). (598 aa) |
| | cacnb4 | SH3 domain-containing protein. (550 aa) |
| | txlna-2 | Taxilin alpha. (843 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (379 aa) |
| | pinx1 | Leucine rich repeat containing 14. (337 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (595 aa) |
| | MGC115642 | Hypothetical protein MGC115642. (1061 aa) |
| | zw10 | Uncharacterized protein. (780 aa) |
| | trim37 | Cysteine-serine-rich nuclear protein 1. (1031 aa) |
| | casp2 | BCR, RhoGEF and GTPase activating protein; Belongs to the peptidase C14A family. (421 aa) |
| | trip13 | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity). (453 aa) |
| | mus81 | Crossover junction endonuclease MUS81; Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity); Belongs to the XPF family. (612 aa) |
| | ccnd1 | Uncharacterized protein; Belongs to the cyclin family. (267 aa) |
| | rilpl1 | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein (By similarity). Belongs to the RILPL family. (404 aa) |
| | e2f8 | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes. Acts as a promoter of sprouting angiogenes [...] (744 aa) |
| | cradd.1 | CASP2 and RIPK1 domain containing adaptor with death domain. (197 aa) |
| | rfwd3 | Heat shock 70 kDa protein 14. (752 aa) |
| | INTS7 | Integrator complex subunit 7. (984 aa) |
| | ppp1r10 | Proteasome 26S subunit, ATPase 6. (844 aa) |
| | gtse1 | Novel protein. (726 aa) |
| | ENSXETP00000028155 | Reverse transcriptase domain-containing protein. (1255 aa) |
| | dtl | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (750 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (368 aa) |
| | cdkn2d | Cyclin-dependent kinase inhibitor 2D (P19, inhibits CDK4). (161 aa) |
| | abca4-3 | ATP binding cassette subfamily A member 4. (174 aa) |
| | bub1 | BUB1 budding uninhibited by benzimidazoles 1 homolog. (1122 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1438 aa) |
| | brcc3 | Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double- [...] (277 aa) |
| | brca1 | Leucine rich repeat containing 18. (1655 aa) |
| | FOXO4 | Forkhead box O4. (492 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (617 aa) |
| | fzr1 | Mucolipin 1. (624 aa) |
| | ttk | Protein kinase domain-containing protein. (879 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | tmem67 | Sideroflexin 5. (989 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2608 aa) |
| | mdm1 | Proteasome (prosome, macropain) subunit, beta type, 7. (738 aa) |
| | nae1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa) |
| | BCL2 | BCL2 apoptosis regulator. (293 aa) |
| | rad1 | RAD1 homolog (S. pombe). (281 aa) |
| | donson | Protein downstream neighbor of son homolog; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. (577 aa) |
| | cdk1 | Cell division cycle 2, G1 to S and G2 to M; Belongs to the protein kinase superfamily. (302 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1402 aa) |
| | tnks | Poly [ADP-ribose] polymerase. (1306 aa) |
| | cdc73 | Hyperparathyroidism 2 (With jaw tumor). (531 aa) |
| | CEP63 | Centrosomal protein 63. (640 aa) |
| | pkd2 | Ubiquitin carboxyl-terminal hydrolase 33. (951 aa) |
| | chfr | E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys- 63'-linked polyubiquit [...] (626 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (307 aa) |
| | rb1 | Uncharacterized protein. (914 aa) |
| | cep44 | Centrosomal protein of 44 kDa. (386 aa) |
| | nme6 | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (179 aa) |
| | bub3 | Uncharacterized protein. (342 aa) |
| | ENSXETP00000039203 | Reverse transcriptase domain-containing protein. (885 aa) |
| | rpa2 | Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (278 aa) |
| | CLSPN | Claspin. (1219 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3060 aa) |
